High mental disorder rates are based on invalid measures: Questions about the claimed ubiquity of mutation-induced dysfunction

Jerome C. Wakefield

    Research output: Contribution to journalArticle

    Abstract

    Three reservations about Keller & Miller's (K&M's) argument are explored: Serious validity problems afflict epidemiological criteria discriminating disorders from non-disorders, so high rates may be misleading. Normal variation need not be mild disorder, contrary to a possible interpretation of K&M's article. And, rather than mutation-selection balance, true disorders may result from unselected combinations of normal variants over many loci.

    Original languageEnglish (US)
    Pages (from-to)424-426
    Number of pages3
    JournalBehavioral and Brain Sciences
    Volume29
    Issue number4
    DOIs
    StatePublished - Aug 1 2006

    Fingerprint

    behavior disorders
    Mental Disorders
    mutagenesis
    mutation
    Mutation
    loci
    need
    rate

    ASJC Scopus subject areas

    • Ecology, Evolution, Behavior and Systematics
    • Neuroscience(all)
    • Psychology(all)
    • Neuropsychology and Physiological Psychology

    Cite this

    High mental disorder rates are based on invalid measures : Questions about the claimed ubiquity of mutation-induced dysfunction. / Wakefield, Jerome C.

    In: Behavioral and Brain Sciences, Vol. 29, No. 4, 01.08.2006, p. 424-426.

    Research output: Contribution to journalArticle

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