Heteropolymer sequence design and preferential solvation of hydrophilic monomers

Application of random energy model

Longhua Hu, Alexander Y. Grosberg

    Research output: Contribution to journalArticle

    Abstract

    We study the role of the surface of the globule and the role of interactions with the solvent for designed-sequence heteropolymers using the random energy model. We investigate the ground-state energy and surface-monomer composition distribution. By comparing the freezing transition in random and designed-sequence heteropolymers, we discuss the effects of design. Based on our results, we are able to show under which conditions the solvation effect improves the quality of the sequence design. Finally, we study sequence-space entropy and discuss the number of available sequences as a function of the imposed requirements for design quality.

    Original languageEnglish (US)
    Article number041921
    JournalPhysical Review E
    Volume75
    Issue number4
    DOIs
    StatePublished - Apr 30 2007

    Fingerprint

    Energy Model
    solvation
    monomers
    globules
    freezing
    energy
    Ground State Energy
    Freezing
    Sequence Space
    entropy
    requirements
    ground state
    Entropy
    Design
    Requirements
    Interaction
    interactions

    ASJC Scopus subject areas

    • Physics and Astronomy(all)
    • Condensed Matter Physics
    • Statistical and Nonlinear Physics
    • Mathematical Physics

    Cite this

    Heteropolymer sequence design and preferential solvation of hydrophilic monomers : Application of random energy model. / Hu, Longhua; Grosberg, Alexander Y.

    In: Physical Review E, Vol. 75, No. 4, 041921, 30.04.2007.

    Research output: Contribution to journalArticle

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