Heterofunctionalized Cavitands by Macrocyclization of Sequence-Defined Foldamers

Joseph W. Meisel, Chunhua T. Hu, Andrew Hamilton

Research output: Contribution to journalArticle

Abstract

Macrocyclic hosts have long been the workhorses of molecular recognition. Despite the widespread use of container-shaped molecules as synthetic receptors, an efficient preparation of cavitands bearing multiple functional groups has not been realized. This Letter describes a new cavitand derived from a sequence-defined oligoamide foldamer scaffold. A solid-phase synthesis approach is reported, which enables the display of multiple chemically diverse functional groups on the cavitand rim.

Original languageEnglish (US)
Pages (from-to)7763-7767
Number of pages5
JournalOrganic Letters
Volume21
Issue number19
DOIs
StatePublished - Oct 4 2019

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Functional groups
Bearings (structural)
Artificial Receptors
Molecular recognition
Solid-Phase Synthesis Techniques
rims
containers
Scaffolds
Containers
solid phases
Display devices
preparation
Molecules
synthesis
molecules
cavitand

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Heterofunctionalized Cavitands by Macrocyclization of Sequence-Defined Foldamers. / Meisel, Joseph W.; Hu, Chunhua T.; Hamilton, Andrew.

In: Organic Letters, Vol. 21, No. 19, 04.10.2019, p. 7763-7767.

Research output: Contribution to journalArticle

Meisel, Joseph W. ; Hu, Chunhua T. ; Hamilton, Andrew. / Heterofunctionalized Cavitands by Macrocyclization of Sequence-Defined Foldamers. In: Organic Letters. 2019 ; Vol. 21, No. 19. pp. 7763-7767.
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