Hetero-assembly of a dual β-amyloid variant peptide system

Jason Candreva, Edward Chau, Edwin Aoraha, Vikas Nanda, Jin Kim

Research output: Contribution to journalArticle

Abstract

Self-assembly of amyloid polypeptides (1) imparts biological effects depending on the size in over 20 amyloid diseases and (2) produces useful yet relatively untapped biomaterials. Unfortunately, our understanding of amyloid polypeptides, as related to biomedical implications and biomaterial applications, is limited by their self-assembling nature. In this study, we report the creation of a dual peptide system, where a pair of β-amyloid (Aβ) variants are not self-assembled but hetero-assembled in the presence of their assembly partners. We provide evidence that the resulting hetero-assemblies share molecular, structural and morphological similarities with typical amyloid self-assemblies formed by a single polypeptide (e.g., Aβ). We anticipate that our dual peptide system may readily be adapted for precise control of amyloid assembly, for the study of size-dependent neurotoxicity and precise fabrication of amyloid biomaterials.

Original languageEnglish (US)
Pages (from-to)6380-6383
Number of pages4
JournalChemical Communications
Volume54
Issue number49
DOIs
StatePublished - Jan 1 2018

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Amyloid
Peptides
Polypeptides
Biocompatible Materials
Biomaterials
Self assembly
Fabrication

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Hetero-assembly of a dual β-amyloid variant peptide system. / Candreva, Jason; Chau, Edward; Aoraha, Edwin; Nanda, Vikas; Kim, Jin.

In: Chemical Communications, Vol. 54, No. 49, 01.01.2018, p. 6380-6383.

Research output: Contribution to journalArticle

Candreva, J, Chau, E, Aoraha, E, Nanda, V & Kim, J 2018, 'Hetero-assembly of a dual β-amyloid variant peptide system', Chemical Communications, vol. 54, no. 49, pp. 6380-6383. https://doi.org/10.1039/c8cc02724b
Candreva, Jason ; Chau, Edward ; Aoraha, Edwin ; Nanda, Vikas ; Kim, Jin. / Hetero-assembly of a dual β-amyloid variant peptide system. In: Chemical Communications. 2018 ; Vol. 54, No. 49. pp. 6380-6383.
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