Heroin and cocaine dependence and the risk of accidental non-fatal drug overdose

Sandro Galea, Ari Nandi, Phillip O. Coffin, Melissa Tracy, Tinka Markham Piper, Danielle Ompad, David Vlahov

Research output: Contribution to journalArticle

Abstract

The relation between illicit drug dependence and the likelihood of drug overdose is unclear. We recruited 1,066 habitual drug users for this analysis through street-based outreach in New York City. In this sample, 99.3% of respondents used heroin in the past year and 87.1% of respondents used cocaine; 819 (77.5%) heroin users and 735 (79.2%) cocaine users were severely dependent on either drug respectively. In multivariable models, among heroin users, persons who were severely heroin dependent were less likely (OR = 0.6; 95% CI = 0.4-0.9) to have overdosed on any drug in the past year; among cocaine users, those who were severely cocaine dependent were more likely (OR = 1.6; 95% CI = 1.0-2.6) to have overdosed in the past year. The relation between illicit drug dependence and risk of overdose may vary for different patterns of drug dependence. These observations suggest that overdose prevention interventions, perhaps even those specifically targeting opiate overdose, may be more efficiently directed at individuals exhibiting cocaine dependence.

Original languageEnglish (US)
Pages (from-to)79-87
Number of pages9
JournalJournal of Addictive Diseases
Volume25
Issue number3
DOIs
StatePublished - Aug 31 2006

Fingerprint

Drug Overdose
Heroin Dependence
Cocaine-Related Disorders
Heroin
Cocaine
Substance-Related Disorders
Street Drugs
Opiate Alkaloids
Drug Users
Pharmaceutical Preparations
Surveys and Questionnaires

Keywords

  • Cocaine
  • Drug dependence
  • Heroin
  • Overdose

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Heroin and cocaine dependence and the risk of accidental non-fatal drug overdose. / Galea, Sandro; Nandi, Ari; Coffin, Phillip O.; Tracy, Melissa; Piper, Tinka Markham; Ompad, Danielle; Vlahov, David.

In: Journal of Addictive Diseases, Vol. 25, No. 3, 31.08.2006, p. 79-87.

Research output: Contribution to journalArticle

Galea, Sandro ; Nandi, Ari ; Coffin, Phillip O. ; Tracy, Melissa ; Piper, Tinka Markham ; Ompad, Danielle ; Vlahov, David. / Heroin and cocaine dependence and the risk of accidental non-fatal drug overdose. In: Journal of Addictive Diseases. 2006 ; Vol. 25, No. 3. pp. 79-87.
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