Hepatitis C virus infection among HIV-positive men who have sex with men

Protocol for a systematic review and meta-analysis

Holly Hagan, Joshua Neurer, Ashly E. Jordan, Don Des Jarlais, Jennifer Wu, Kirk Dombrowski, Bilal Khan, Ronald S. Braithwaite, Jason Kessler

Research output: Contribution to journalArticle

Abstract

Background: Outbreaks of hepatitis C virus (HCV) infection have been reported in HIV-positive men who have sex with men (MSM) in North America, Europe and Asia. Transmission is believed to be the result of exposure to blood during sexual contact. In those infected with HIV, acute HCV infection is more likely to become chronic, treatment for both HIV and HCV is more complicated and HCV disease progression may be accelerated. There is a need for systematic reviews and meta-analyses to synthesize the epidemiology, prevention and methods to control HCV infection in this population. Methods/design: Eligible studies will include quantitative empirical data related to sexual transmission of HCV in HIV-positive MSM, including data describing incidence or prevalence, and associations between risk factors or interventions and the occurrence or progression of HCV disease. Care will be taken to ensure that HCV transmission related to injection drug use is excluded from the incidence estimates. Scientific databases will be searched using a comprehensive search strategy. Proceedings of scientific conferences, reference lists and personal files will also be searched. Quality ratings will be assigned to each eligible report using the Newcastle-Ottawa scale. Pooled estimates of incidence rates and measures of association will be calculated using random effects models. Heterogeneity will be assessed at each stage of data synthesis. Discussion: HIV-positive MSM are a key HCV-affected population in the US and other high-income countries. This review seeks to identify modifiable risk factors and settings that will be the target of interventions, and will consider how to constitute a portfolio of interventions to deliver the greatest health benefit. This question must be considered in relation to the magnitude of HCV infection and its consequences in other key affected populations, namely, young prescription opioid users who have transitioned to illicit opiate injection, and older injection drug users among whom HCV prevalence and incidence are extremely high. This review is part of a series of systematic reviews and meta-analyses that will synthesize the evidence across all these population groups and develop recommendations and decision tools to guide public health resource allocation. Trial registration: PROSPERO registration number: CRD42013006462.

Original languageEnglish (US)
Article number31
JournalSystematic Reviews
Volume3
Issue number1
DOIs
StatePublished - Mar 26 2014

Fingerprint

Virus Diseases
Hepacivirus
Meta-Analysis
HIV
Incidence
Injections
Opiate Alkaloids
Northern Asia
Population
Resource Allocation
Health Resources
Insurance Benefits
North America
Drug Users
Population Groups
Opioid Analgesics
Disease Outbreaks
Prescriptions
Disease Progression
Epidemiology

Keywords

  • Epidemiology
  • Hepatitis C virus
  • HIV infection
  • Men who have sex with men
  • Systematic review

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Hepatitis C virus infection among HIV-positive men who have sex with men : Protocol for a systematic review and meta-analysis. / Hagan, Holly; Neurer, Joshua; Jordan, Ashly E.; Des Jarlais, Don; Wu, Jennifer; Dombrowski, Kirk; Khan, Bilal; Braithwaite, Ronald S.; Kessler, Jason.

In: Systematic Reviews, Vol. 3, No. 1, 31, 26.03.2014.

Research output: Contribution to journalArticle

Hagan, Holly ; Neurer, Joshua ; Jordan, Ashly E. ; Des Jarlais, Don ; Wu, Jennifer ; Dombrowski, Kirk ; Khan, Bilal ; Braithwaite, Ronald S. ; Kessler, Jason. / Hepatitis C virus infection among HIV-positive men who have sex with men : Protocol for a systematic review and meta-analysis. In: Systematic Reviews. 2014 ; Vol. 3, No. 1.
@article{a35d32c4cb15464a9fbf547d91818783,
title = "Hepatitis C virus infection among HIV-positive men who have sex with men: Protocol for a systematic review and meta-analysis",
abstract = "Background: Outbreaks of hepatitis C virus (HCV) infection have been reported in HIV-positive men who have sex with men (MSM) in North America, Europe and Asia. Transmission is believed to be the result of exposure to blood during sexual contact. In those infected with HIV, acute HCV infection is more likely to become chronic, treatment for both HIV and HCV is more complicated and HCV disease progression may be accelerated. There is a need for systematic reviews and meta-analyses to synthesize the epidemiology, prevention and methods to control HCV infection in this population. Methods/design: Eligible studies will include quantitative empirical data related to sexual transmission of HCV in HIV-positive MSM, including data describing incidence or prevalence, and associations between risk factors or interventions and the occurrence or progression of HCV disease. Care will be taken to ensure that HCV transmission related to injection drug use is excluded from the incidence estimates. Scientific databases will be searched using a comprehensive search strategy. Proceedings of scientific conferences, reference lists and personal files will also be searched. Quality ratings will be assigned to each eligible report using the Newcastle-Ottawa scale. Pooled estimates of incidence rates and measures of association will be calculated using random effects models. Heterogeneity will be assessed at each stage of data synthesis. Discussion: HIV-positive MSM are a key HCV-affected population in the US and other high-income countries. This review seeks to identify modifiable risk factors and settings that will be the target of interventions, and will consider how to constitute a portfolio of interventions to deliver the greatest health benefit. This question must be considered in relation to the magnitude of HCV infection and its consequences in other key affected populations, namely, young prescription opioid users who have transitioned to illicit opiate injection, and older injection drug users among whom HCV prevalence and incidence are extremely high. This review is part of a series of systematic reviews and meta-analyses that will synthesize the evidence across all these population groups and develop recommendations and decision tools to guide public health resource allocation. Trial registration: PROSPERO registration number: CRD42013006462.",
keywords = "Epidemiology, Hepatitis C virus, HIV infection, Men who have sex with men, Systematic review",
author = "Holly Hagan and Joshua Neurer and Jordan, {Ashly E.} and {Des Jarlais}, Don and Jennifer Wu and Kirk Dombrowski and Bilal Khan and Braithwaite, {Ronald S.} and Jason Kessler",
year = "2014",
month = "3",
day = "26",
doi = "10.1186/2046-4053-3-31",
language = "English (US)",
volume = "3",
journal = "Systematic Reviews",
issn = "2046-4053",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Hepatitis C virus infection among HIV-positive men who have sex with men

T2 - Protocol for a systematic review and meta-analysis

AU - Hagan, Holly

AU - Neurer, Joshua

AU - Jordan, Ashly E.

AU - Des Jarlais, Don

AU - Wu, Jennifer

AU - Dombrowski, Kirk

AU - Khan, Bilal

AU - Braithwaite, Ronald S.

AU - Kessler, Jason

PY - 2014/3/26

Y1 - 2014/3/26

N2 - Background: Outbreaks of hepatitis C virus (HCV) infection have been reported in HIV-positive men who have sex with men (MSM) in North America, Europe and Asia. Transmission is believed to be the result of exposure to blood during sexual contact. In those infected with HIV, acute HCV infection is more likely to become chronic, treatment for both HIV and HCV is more complicated and HCV disease progression may be accelerated. There is a need for systematic reviews and meta-analyses to synthesize the epidemiology, prevention and methods to control HCV infection in this population. Methods/design: Eligible studies will include quantitative empirical data related to sexual transmission of HCV in HIV-positive MSM, including data describing incidence or prevalence, and associations between risk factors or interventions and the occurrence or progression of HCV disease. Care will be taken to ensure that HCV transmission related to injection drug use is excluded from the incidence estimates. Scientific databases will be searched using a comprehensive search strategy. Proceedings of scientific conferences, reference lists and personal files will also be searched. Quality ratings will be assigned to each eligible report using the Newcastle-Ottawa scale. Pooled estimates of incidence rates and measures of association will be calculated using random effects models. Heterogeneity will be assessed at each stage of data synthesis. Discussion: HIV-positive MSM are a key HCV-affected population in the US and other high-income countries. This review seeks to identify modifiable risk factors and settings that will be the target of interventions, and will consider how to constitute a portfolio of interventions to deliver the greatest health benefit. This question must be considered in relation to the magnitude of HCV infection and its consequences in other key affected populations, namely, young prescription opioid users who have transitioned to illicit opiate injection, and older injection drug users among whom HCV prevalence and incidence are extremely high. This review is part of a series of systematic reviews and meta-analyses that will synthesize the evidence across all these population groups and develop recommendations and decision tools to guide public health resource allocation. Trial registration: PROSPERO registration number: CRD42013006462.

AB - Background: Outbreaks of hepatitis C virus (HCV) infection have been reported in HIV-positive men who have sex with men (MSM) in North America, Europe and Asia. Transmission is believed to be the result of exposure to blood during sexual contact. In those infected with HIV, acute HCV infection is more likely to become chronic, treatment for both HIV and HCV is more complicated and HCV disease progression may be accelerated. There is a need for systematic reviews and meta-analyses to synthesize the epidemiology, prevention and methods to control HCV infection in this population. Methods/design: Eligible studies will include quantitative empirical data related to sexual transmission of HCV in HIV-positive MSM, including data describing incidence or prevalence, and associations between risk factors or interventions and the occurrence or progression of HCV disease. Care will be taken to ensure that HCV transmission related to injection drug use is excluded from the incidence estimates. Scientific databases will be searched using a comprehensive search strategy. Proceedings of scientific conferences, reference lists and personal files will also be searched. Quality ratings will be assigned to each eligible report using the Newcastle-Ottawa scale. Pooled estimates of incidence rates and measures of association will be calculated using random effects models. Heterogeneity will be assessed at each stage of data synthesis. Discussion: HIV-positive MSM are a key HCV-affected population in the US and other high-income countries. This review seeks to identify modifiable risk factors and settings that will be the target of interventions, and will consider how to constitute a portfolio of interventions to deliver the greatest health benefit. This question must be considered in relation to the magnitude of HCV infection and its consequences in other key affected populations, namely, young prescription opioid users who have transitioned to illicit opiate injection, and older injection drug users among whom HCV prevalence and incidence are extremely high. This review is part of a series of systematic reviews and meta-analyses that will synthesize the evidence across all these population groups and develop recommendations and decision tools to guide public health resource allocation. Trial registration: PROSPERO registration number: CRD42013006462.

KW - Epidemiology

KW - Hepatitis C virus

KW - HIV infection

KW - Men who have sex with men

KW - Systematic review

UR - http://www.scopus.com/inward/record.url?scp=84905649082&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905649082&partnerID=8YFLogxK

U2 - 10.1186/2046-4053-3-31

DO - 10.1186/2046-4053-3-31

M3 - Article

VL - 3

JO - Systematic Reviews

JF - Systematic Reviews

SN - 2046-4053

IS - 1

M1 - 31

ER -