Helicobacter pylori colonization is inversely associated with childhood asthma

Yu Chen, Martin J. Blaser

Research output: Contribution to journalArticle

Abstract

Background. Asthma, a serious health problem worldwide, is becoming more common. Colonization with Helicobacter pylori, a major human indigenous (commensal) microbe, during early life may be relevant to the risk of childhood asthma. Methods. We conducted cross-sectional analyses, using data from 7412 participants in the National Health and Nutrition Examination Survey (NHANES) 1999-2000, to assess the association between H. pylori and childhood asthma. Results. H. pylori seropositivity was inversely associated with onset of asthma before 5 years of age and current asthma in children aged 3-13 years. Among participants 3-19 years of age, the presence of H. pylori was inversely related to ever having had asthma (odds ratio [OR], 0.69; 95% confidence interval [CI], 0.45-1.06), and the inverse association with onset of asthma before 5 years of age was stronger (OR, 0.58; 95% CI, 0.38-0.88). Among participants 3-13 years of age, H. pylori positivity was significantly inversely associated with current asthma (OR, 0.41; 95% CI, 0.24-0.69). H. pylori seropositivity also was inversely related to recent wheezing, allergic rhinitis, and dermatitis, eczema, or rash. Conclusions. This study is the first to report an inverse association between H. pylori seropositivity and asthma in children. The findings indicate new directions for research and asthma prevention.

Original languageEnglish (US)
Pages (from-to)553-560
Number of pages8
JournalJournal of Infectious Diseases
Volume198
Issue number4
DOIs
StatePublished - Aug 15 2008

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Helicobacter pylori
Asthma
Odds Ratio
Confidence Intervals
Nutrition Surveys
Eczema
Respiratory Sounds
Dermatitis
Exanthema
Cross-Sectional Studies
Research

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Helicobacter pylori colonization is inversely associated with childhood asthma. / Chen, Yu; Blaser, Martin J.

In: Journal of Infectious Diseases, Vol. 198, No. 4, 15.08.2008, p. 553-560.

Research output: Contribution to journalArticle

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