Hebbian and neuromodulatory mechanisms interact to trigger associative memory formation

Joshua P. Johansen, Lorenzo Diaz-Mataix, Hiroki Hamanaka, Takaaki Ozawa, Edgar Ycu, Jenny Koivumaa, Ashwani Kumar, Mian Hou, Karl Deisseroth, Edward S. Boyden, Joseph Ledoux

Research output: Contribution to journalArticle

Abstract

A long-standing hypothesis termed "Hebbian plasticity" suggests that memories are formed through strengthening of synaptic connections between neurons with correlated activity. In contrast, other theories propose that coactivation of Hebbian and neuromodulatory processes produce the synaptic strengthening that underlies memory formation. Using optogenetics we directly tested whether Hebbian plasticity alone is both necessary and sufficient to produce physiological changes mediating actual memory formation in behaving animals. Our previous work with this method suggested that Hebbian mechanisms are sufficient to produce aversive associative learning under artificial conditions involving strong, iterative training. Here we systematically tested whether Hebbian mechanisms are necessary and sufficient to produce associative learning under more moderate training conditions that are similar to those that occur in daily life. We measured neural plasticity in the lateral amygdala, a brain region important for associative memory storage about danger. Our findings provide evidence that Hebbian mechanisms are necessary to produce neural plasticity in the lateral amygdala and behavioral memory formation. However, under these conditions Hebbian mechanisms alone were not sufficient to produce these physiological and behavioral effects unless neuromodulatory systems were coactivated. These results provide insight into how aversive experiences trigger memories and suggest that combined Hebbian and neuromodulatory processes interact to engage associative aversive learning.

Original languageEnglish (US)
Pages (from-to)E5584-E5592
JournalProceedings of the National Academy of Sciences of the United States of America
Volume111
Issue number51
DOIs
StatePublished - Dec 23 2014

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Neuronal Plasticity
Learning
Amygdala
Optogenetics
Neurons
Brain

Keywords

  • Amygdala
  • Associative learning
  • Hebbian plasticity
  • Instructive signals
  • Neuromodulation

ASJC Scopus subject areas

  • General

Cite this

Hebbian and neuromodulatory mechanisms interact to trigger associative memory formation. / Johansen, Joshua P.; Diaz-Mataix, Lorenzo; Hamanaka, Hiroki; Ozawa, Takaaki; Ycu, Edgar; Koivumaa, Jenny; Kumar, Ashwani; Hou, Mian; Deisseroth, Karl; Boyden, Edward S.; Ledoux, Joseph.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 51, 23.12.2014, p. E5584-E5592.

Research output: Contribution to journalArticle

Johansen, JP, Diaz-Mataix, L, Hamanaka, H, Ozawa, T, Ycu, E, Koivumaa, J, Kumar, A, Hou, M, Deisseroth, K, Boyden, ES & Ledoux, J 2014, 'Hebbian and neuromodulatory mechanisms interact to trigger associative memory formation', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 51, pp. E5584-E5592. https://doi.org/10.1073/pnas.1421304111
Johansen, Joshua P. ; Diaz-Mataix, Lorenzo ; Hamanaka, Hiroki ; Ozawa, Takaaki ; Ycu, Edgar ; Koivumaa, Jenny ; Kumar, Ashwani ; Hou, Mian ; Deisseroth, Karl ; Boyden, Edward S. ; Ledoux, Joseph. / Hebbian and neuromodulatory mechanisms interact to trigger associative memory formation. In: Proceedings of the National Academy of Sciences of the United States of America. 2014 ; Vol. 111, No. 51. pp. E5584-E5592.
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