### Abstract

Insect navigation is guided by heading vectors that are computed by path integration. Mammalian navigation models, on the other hand, are typically based on map-like place representations provided by hippocampal place cells. Such models compute optimal routes as a continuous series of locations that connect the current location to a goal. We propose a ''heading-vector'' model in which head-direction cells or their derivatives serve both as key elements in constructing the optimal route and as the straight-line guidance during route execution. The model is based on a memory structure termed the ''shortcut matrix,'' which is constructed during the initial exploration of an environment when a set of shortcut vectors between sequential pairs of visited waypoint locations is stored. A mechanism is proposed for calculating and storing these vectors that relies on a hypothesized cell type termed an ''accumulating head-direction cell.'' Following exploration, shortcut vectors connecting all pairs of waypoint locations are computed by vector arithmetic and stored in the shortcut matrix. On re-entry, when local view or place representations query the shortcut matrix with a current waypoint and goal, a shortcut trajectory is retrieved. Since the trajectory direction is in head-direction compass coordinates, navigation is accomplished by tracking the firing of head-direction cells that are tuned to the heading angle. Section 1 of the manuscript describes the properties of accumulating head-direction cells. It then shows how accumulating head-direction cells can store local vectors and perform vector arithmetic to perform path-integration-based homing. Section 2 describes the construction and use of the shortcut matrix for computing direct paths between any pair of locations that have been registered in the shortcut matrix. In the discussion, we analyze the advantages of heading-based navigation over map-based navigation. Finally, we survey behavioral evidence that nonhippocampal, heading-based navigation is used in small mammals and humans.

Original language | English (US) |
---|---|

Pages (from-to) | 456-479 |

Number of pages | 24 |

Journal | Hippocampus |

Volume | 19 |

Issue number | 5 |

DOIs | |

State | Published - May 2009 |

### Fingerprint

### Keywords

- Head direction cell
- Hippocampus
- Navigation
- Place cell

### ASJC Scopus subject areas

- Cognitive Neuroscience

### Cite this

*Hippocampus*,

*19*(5), 456-479. https://doi.org/10.1002/hipo.20532

**Heading-Vector navigation based on head direction cells and path integration.** / Kubie, John L.; Fenton, Andre.

Research output: Contribution to journal › Article

*Hippocampus*, vol. 19, no. 5, pp. 456-479. https://doi.org/10.1002/hipo.20532

}

TY - JOUR

T1 - Heading-Vector navigation based on head direction cells and path integration

AU - Kubie, John L.

AU - Fenton, Andre

PY - 2009/5

Y1 - 2009/5

N2 - Insect navigation is guided by heading vectors that are computed by path integration. Mammalian navigation models, on the other hand, are typically based on map-like place representations provided by hippocampal place cells. Such models compute optimal routes as a continuous series of locations that connect the current location to a goal. We propose a ''heading-vector'' model in which head-direction cells or their derivatives serve both as key elements in constructing the optimal route and as the straight-line guidance during route execution. The model is based on a memory structure termed the ''shortcut matrix,'' which is constructed during the initial exploration of an environment when a set of shortcut vectors between sequential pairs of visited waypoint locations is stored. A mechanism is proposed for calculating and storing these vectors that relies on a hypothesized cell type termed an ''accumulating head-direction cell.'' Following exploration, shortcut vectors connecting all pairs of waypoint locations are computed by vector arithmetic and stored in the shortcut matrix. On re-entry, when local view or place representations query the shortcut matrix with a current waypoint and goal, a shortcut trajectory is retrieved. Since the trajectory direction is in head-direction compass coordinates, navigation is accomplished by tracking the firing of head-direction cells that are tuned to the heading angle. Section 1 of the manuscript describes the properties of accumulating head-direction cells. It then shows how accumulating head-direction cells can store local vectors and perform vector arithmetic to perform path-integration-based homing. Section 2 describes the construction and use of the shortcut matrix for computing direct paths between any pair of locations that have been registered in the shortcut matrix. In the discussion, we analyze the advantages of heading-based navigation over map-based navigation. Finally, we survey behavioral evidence that nonhippocampal, heading-based navigation is used in small mammals and humans.

AB - Insect navigation is guided by heading vectors that are computed by path integration. Mammalian navigation models, on the other hand, are typically based on map-like place representations provided by hippocampal place cells. Such models compute optimal routes as a continuous series of locations that connect the current location to a goal. We propose a ''heading-vector'' model in which head-direction cells or their derivatives serve both as key elements in constructing the optimal route and as the straight-line guidance during route execution. The model is based on a memory structure termed the ''shortcut matrix,'' which is constructed during the initial exploration of an environment when a set of shortcut vectors between sequential pairs of visited waypoint locations is stored. A mechanism is proposed for calculating and storing these vectors that relies on a hypothesized cell type termed an ''accumulating head-direction cell.'' Following exploration, shortcut vectors connecting all pairs of waypoint locations are computed by vector arithmetic and stored in the shortcut matrix. On re-entry, when local view or place representations query the shortcut matrix with a current waypoint and goal, a shortcut trajectory is retrieved. Since the trajectory direction is in head-direction compass coordinates, navigation is accomplished by tracking the firing of head-direction cells that are tuned to the heading angle. Section 1 of the manuscript describes the properties of accumulating head-direction cells. It then shows how accumulating head-direction cells can store local vectors and perform vector arithmetic to perform path-integration-based homing. Section 2 describes the construction and use of the shortcut matrix for computing direct paths between any pair of locations that have been registered in the shortcut matrix. In the discussion, we analyze the advantages of heading-based navigation over map-based navigation. Finally, we survey behavioral evidence that nonhippocampal, heading-based navigation is used in small mammals and humans.

KW - Head direction cell

KW - Hippocampus

KW - Navigation

KW - Place cell

UR - http://www.scopus.com/inward/record.url?scp=66049089153&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66049089153&partnerID=8YFLogxK

U2 - 10.1002/hipo.20532

DO - 10.1002/hipo.20532

M3 - Article

C2 - 19072761

AN - SCOPUS:66049089153

VL - 19

SP - 456

EP - 479

JO - Hippocampus

JF - Hippocampus

SN - 1050-9631

IS - 5

ER -