Head unrestrained horizontal gaze shifts after unilateral labyrinthectomy in the rhesus monkey

S. D. Newlands, S. V. Hesse, A. Haque, Dora Angelaki

Research output: Contribution to journalArticle

Abstract

Following the orienting saccade of a combined eye-head gaze shift, normal monkeys exhibit a compensatory eye counterrotation that stabilizes gaze as the head movement continues. This counterrotation, which has a gain (eye velocity/head velocity) of near unity, is a manifestation of the vestibulo-ocular reflex (VOR). Acute unilateral labyrinthectomy (UL) causes severe asymmetry in the VOR during passive head rotations that recovers incompletely over time. The purpose of this investigation was to compare the recovery of the counterrotation gain during horizontal gaze shifts with that of the passive VOR after UL. During the 1st week after UL, counterrotation gains were asymmetric, being lower for head movements towards the lesion but nearly normal for head movements towards the intact side. Whereas this asymmetry in the counterrotation gain resolved within a week after UL, asymmetries in the passive VOR persisted. During the 1st week after UL, behavioral performance was generally poor, with a high incidence of inaccurate gaze shifts and larger latencies. In addition, animals used slower head movements such that peak head amplitude during the eye saccade was significantly lower during the 1st week after UL as compared to control values. Bilateral labyrinthectomy (BL) resulted in larger but symmetric deficits in counterrotation, which, contrary to the passive VOR, exhibited significant recovery over time. It is hypothesized that recovery of counterrotation gain after UL has contributions from multiple sources, including the contralateral intact labyrinth and an efference copy of the head movement.

Original languageEnglish (US)
Pages (from-to)25-33
Number of pages9
JournalExperimental Brain Research
Volume140
Issue number1
DOIs
StatePublished - Jan 1 2001

Fingerprint

Vestibulo-Ocular Reflex
Head Movements
Macaca mulatta
Head
Saccades
Inner Ear
Haplorhini
Incidence

Keywords

  • Gaze stabilization
  • Head-free
  • Semicircular canals
  • Vestibular
  • VOR

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Head unrestrained horizontal gaze shifts after unilateral labyrinthectomy in the rhesus monkey. / Newlands, S. D.; Hesse, S. V.; Haque, A.; Angelaki, Dora.

In: Experimental Brain Research, Vol. 140, No. 1, 01.01.2001, p. 25-33.

Research output: Contribution to journalArticle

@article{938db686151b4c7ebf466b9b1c6a5d87,
title = "Head unrestrained horizontal gaze shifts after unilateral labyrinthectomy in the rhesus monkey",
abstract = "Following the orienting saccade of a combined eye-head gaze shift, normal monkeys exhibit a compensatory eye counterrotation that stabilizes gaze as the head movement continues. This counterrotation, which has a gain (eye velocity/head velocity) of near unity, is a manifestation of the vestibulo-ocular reflex (VOR). Acute unilateral labyrinthectomy (UL) causes severe asymmetry in the VOR during passive head rotations that recovers incompletely over time. The purpose of this investigation was to compare the recovery of the counterrotation gain during horizontal gaze shifts with that of the passive VOR after UL. During the 1st week after UL, counterrotation gains were asymmetric, being lower for head movements towards the lesion but nearly normal for head movements towards the intact side. Whereas this asymmetry in the counterrotation gain resolved within a week after UL, asymmetries in the passive VOR persisted. During the 1st week after UL, behavioral performance was generally poor, with a high incidence of inaccurate gaze shifts and larger latencies. In addition, animals used slower head movements such that peak head amplitude during the eye saccade was significantly lower during the 1st week after UL as compared to control values. Bilateral labyrinthectomy (BL) resulted in larger but symmetric deficits in counterrotation, which, contrary to the passive VOR, exhibited significant recovery over time. It is hypothesized that recovery of counterrotation gain after UL has contributions from multiple sources, including the contralateral intact labyrinth and an efference copy of the head movement.",
keywords = "Gaze stabilization, Head-free, Semicircular canals, Vestibular, VOR",
author = "Newlands, {S. D.} and Hesse, {S. V.} and A. Haque and Dora Angelaki",
year = "2001",
month = "1",
day = "1",
doi = "10.1007/s002210100810",
language = "English (US)",
volume = "140",
pages = "25--33",
journal = "Experimental Brain Research",
issn = "0014-4819",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Head unrestrained horizontal gaze shifts after unilateral labyrinthectomy in the rhesus monkey

AU - Newlands, S. D.

AU - Hesse, S. V.

AU - Haque, A.

AU - Angelaki, Dora

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Following the orienting saccade of a combined eye-head gaze shift, normal monkeys exhibit a compensatory eye counterrotation that stabilizes gaze as the head movement continues. This counterrotation, which has a gain (eye velocity/head velocity) of near unity, is a manifestation of the vestibulo-ocular reflex (VOR). Acute unilateral labyrinthectomy (UL) causes severe asymmetry in the VOR during passive head rotations that recovers incompletely over time. The purpose of this investigation was to compare the recovery of the counterrotation gain during horizontal gaze shifts with that of the passive VOR after UL. During the 1st week after UL, counterrotation gains were asymmetric, being lower for head movements towards the lesion but nearly normal for head movements towards the intact side. Whereas this asymmetry in the counterrotation gain resolved within a week after UL, asymmetries in the passive VOR persisted. During the 1st week after UL, behavioral performance was generally poor, with a high incidence of inaccurate gaze shifts and larger latencies. In addition, animals used slower head movements such that peak head amplitude during the eye saccade was significantly lower during the 1st week after UL as compared to control values. Bilateral labyrinthectomy (BL) resulted in larger but symmetric deficits in counterrotation, which, contrary to the passive VOR, exhibited significant recovery over time. It is hypothesized that recovery of counterrotation gain after UL has contributions from multiple sources, including the contralateral intact labyrinth and an efference copy of the head movement.

AB - Following the orienting saccade of a combined eye-head gaze shift, normal monkeys exhibit a compensatory eye counterrotation that stabilizes gaze as the head movement continues. This counterrotation, which has a gain (eye velocity/head velocity) of near unity, is a manifestation of the vestibulo-ocular reflex (VOR). Acute unilateral labyrinthectomy (UL) causes severe asymmetry in the VOR during passive head rotations that recovers incompletely over time. The purpose of this investigation was to compare the recovery of the counterrotation gain during horizontal gaze shifts with that of the passive VOR after UL. During the 1st week after UL, counterrotation gains were asymmetric, being lower for head movements towards the lesion but nearly normal for head movements towards the intact side. Whereas this asymmetry in the counterrotation gain resolved within a week after UL, asymmetries in the passive VOR persisted. During the 1st week after UL, behavioral performance was generally poor, with a high incidence of inaccurate gaze shifts and larger latencies. In addition, animals used slower head movements such that peak head amplitude during the eye saccade was significantly lower during the 1st week after UL as compared to control values. Bilateral labyrinthectomy (BL) resulted in larger but symmetric deficits in counterrotation, which, contrary to the passive VOR, exhibited significant recovery over time. It is hypothesized that recovery of counterrotation gain after UL has contributions from multiple sources, including the contralateral intact labyrinth and an efference copy of the head movement.

KW - Gaze stabilization

KW - Head-free

KW - Semicircular canals

KW - Vestibular

KW - VOR

UR - http://www.scopus.com/inward/record.url?scp=0034879544&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034879544&partnerID=8YFLogxK

U2 - 10.1007/s002210100810

DO - 10.1007/s002210100810

M3 - Article

C2 - 11500795

AN - SCOPUS:0034879544

VL - 140

SP - 25

EP - 33

JO - Experimental Brain Research

JF - Experimental Brain Research

SN - 0014-4819

IS - 1

ER -