Guided Tissue Regeneration in Periapical Surgery

Louis Lin, Melody Y H Chen, Domenico Ricucci, Paul Rosenberg

Research output: Contribution to journalArticle

Abstract

Tissue regeneration by using membrane barriers and bone grafting materials in periapical surgery is an example of tissue engineering technology. Membrane barriers and/or bone grafts are often used to enhance periapical new bone formation. However, the periapical tissues also consist of the periodontal ligament (PDL) and cementum. For regeneration of the periapical tissues after periapical surgery, one of the important requirements is recruitment and differentiation of progenitor/stem cells into committed pre-osteoblasts, pre-PDL cells, and pre-cementoblasts. Homing of progenitor/stem cells into the wounded periapical tissues is regulated by factors such as stromal cell-derived factor 1, growth factors/cytokines, and by microenvironmental cues such as adhesion molecules and extracellular matrix and associated noncollagenous molecules. Tissue regeneration after injury appears to recapitulate the pathway of normal embryonic tissue development. Multiple tissue regeneration involves a complex interaction between different cells, extracellular matrix, growth/differentiation factors, and microenvironmental cues. Little is known concerning the biologic mechanisms that regulate temporal and spatial relationship between alveolar bone, PDL, and cementum regeneration during periapical wound healing. Simply applying a membrane barrier and/or bone graft during periapical surgery might not result in complete regeneration of the periapical tissues. It has not been clearly demonstrated that these biomaterials are capable of recruiting progenitor/stem cells and inducing these undifferentiated mesenchymal cells to differentiate into PDL cells and cementoblasts after periapical surgery.

Original languageEnglish (US)
Pages (from-to)618-625
Number of pages8
JournalJournal of Endodontics
Volume36
Issue number4
DOIs
StatePublished - Apr 2010

Fingerprint

Guided Tissue Regeneration
Periapical Tissue
Dental Cementum
Regeneration
Periodontal Ligament
Stem Cells
Bone and Bones
Cues
Extracellular Matrix
Membranes
Growth Differentiation Factors
Transplants
Chemokine CXCL12
Bone Transplantation
Biocompatible Materials
Tissue Engineering
Osteoblasts
Osteogenesis
Wound Healing
Embryonic Development

Keywords

  • Bone grafting materials
  • guided tissue regeneration
  • membrane barriers
  • periapical surgery

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Guided Tissue Regeneration in Periapical Surgery. / Lin, Louis; Chen, Melody Y H; Ricucci, Domenico; Rosenberg, Paul.

In: Journal of Endodontics, Vol. 36, No. 4, 04.2010, p. 618-625.

Research output: Contribution to journalArticle

Lin, Louis ; Chen, Melody Y H ; Ricucci, Domenico ; Rosenberg, Paul. / Guided Tissue Regeneration in Periapical Surgery. In: Journal of Endodontics. 2010 ; Vol. 36, No. 4. pp. 618-625.
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