Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice

Yingjie Wu, Chengyu Liu, Hui Sun, Archana Vijayakumar, Pejman Raeisi Giglou, Ruifang Qiao, Joshua Oppenheimer, Shoshana Yakar, Derek LeRoith

Research output: Contribution to journalArticle

Abstract

Insulin, growth hormone (GH), and insulin-like growth factor-1 (IGF-1) play key roles in the regulation of β cell growth and function. Although β cells express the GH receptor, the direct effects of GH on β cells remain largely unknown. Here we have employed a rat insulin II promoter-driven (RIP-driven) Cre recombinase to disrupt the GH receptor in β cells (βGHRKO). βGHRKO mice fed a standard chow diet exhibited impaired glucose-stimulated insulin secretion but had no changes in β cell mass. When challenged with a high-fat diet, βGHRKO mice showed evidence of a β cell secretory defect, with further deterioration of glucose homeostasis indicated by their altered glucose tolerance and blunted glucose-stimulated insulin secretion. Interestingly, βGHRKO mice were impaired in β cell hyperplasia in response to a high-fat diet, with decreased β cell proliferation and overall reduced β cell mass. Therefore, GH receptor plays critical roles in glucose-stimulated insulin secretion and β cell compensation in response to a high-fat diet.

Original languageEnglish (US)
Pages (from-to)2422-2426
Number of pages5
JournalJournal of Clinical Investigation
Volume121
Issue number6
DOIs
StatePublished - Jun 1 2011

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Somatotropin Receptors
Obese Mice
Hyperplasia
Insulin
Glucose
High Fat Diet
Growth Hormone
Somatomedins
Homeostasis
Cell Proliferation
Diet

ASJC Scopus subject areas

  • Medicine(all)

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Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice. / Wu, Yingjie; Liu, Chengyu; Sun, Hui; Vijayakumar, Archana; Giglou, Pejman Raeisi; Qiao, Ruifang; Oppenheimer, Joshua; Yakar, Shoshana; LeRoith, Derek.

In: Journal of Clinical Investigation, Vol. 121, No. 6, 01.06.2011, p. 2422-2426.

Research output: Contribution to journalArticle

Wu, Y, Liu, C, Sun, H, Vijayakumar, A, Giglou, PR, Qiao, R, Oppenheimer, J, Yakar, S & LeRoith, D 2011, 'Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice', Journal of Clinical Investigation, vol. 121, no. 6, pp. 2422-2426. https://doi.org/10.1172/JCI45027
Wu, Yingjie ; Liu, Chengyu ; Sun, Hui ; Vijayakumar, Archana ; Giglou, Pejman Raeisi ; Qiao, Ruifang ; Oppenheimer, Joshua ; Yakar, Shoshana ; LeRoith, Derek. / Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice. In: Journal of Clinical Investigation. 2011 ; Vol. 121, No. 6. pp. 2422-2426.
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