Growth hormone protects against ovariectomy-induced bone loss in states of low circulating Insulin-like Growth Factor (IGF-1)

J. Christopher Fritton, Kelly B. Emerton, Hui Sun, Yuki Kawashima, Wilson Mejia, Yingjie Wu, Clifford J. Rosen, David Panus, Mary Bouxsein, Robert J. Majeska, Mitchell B. Schaffler, Shoshana Yakar

Research output: Contribution to journalArticle

Abstract

Early after estrogen loss in postmenopausal women and ovariectomy (OVX) of animals, accelerated endosteal bone resorption leads to marrow expansion of long bone shafts that reduce mechanical integrity. Both growth hormone (GH) and insulin-like growth factor (IGF-1) are potent regulators of bone remodeling processes. To investigate the role of the GH/IGF-1 axis with estrogen deficiency, we used the liver IGF-1-deficient (LID) mouse. Contrary to deficits in controls, OVX of LID mice resulted in maintenance of cortical bone mechanical integrity primarily owing to an enhanced periosteal expansion affect on cross-sectional structure (total area and cortical width). The serum balance in LID that favors GH over IGF-1 diminished the effects of ablated ovarian function on numbers of osteoclast precursors in the marrow and viability of osteocytes within the cortical matrix and led to less endosteal resorption in addition to greater periosteal bone formation. Interactions between estrogen and the GH/IGF-1 system as related to bone remodeling provide a pathway to minimize degeneration of bone tissue structure and osteoporotic fracture.

Original languageEnglish (US)
Pages (from-to)235-246
Number of pages12
JournalJournal of Bone and Mineral Research
Volume25
Issue number2
DOIs
StatePublished - 2010

Fingerprint

Ovariectomy
Somatomedins
Insulin-Like Growth Factor I
Growth Hormone
Bone and Bones
Estrogens
Bone Remodeling
Liver
Bone Marrow
Osteocytes
Osteoporotic Fractures
Osteoclasts
Bone Resorption
Osteogenesis
Maintenance
Serum

Keywords

  • Apoptosis
  • Estrogen
  • Growth factors
  • Osteoporosis
  • Remodeling

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Growth hormone protects against ovariectomy-induced bone loss in states of low circulating Insulin-like Growth Factor (IGF-1). / Fritton, J. Christopher; Emerton, Kelly B.; Sun, Hui; Kawashima, Yuki; Mejia, Wilson; Wu, Yingjie; Rosen, Clifford J.; Panus, David; Bouxsein, Mary; Majeska, Robert J.; Schaffler, Mitchell B.; Yakar, Shoshana.

In: Journal of Bone and Mineral Research, Vol. 25, No. 2, 2010, p. 235-246.

Research output: Contribution to journalArticle

Fritton, JC, Emerton, KB, Sun, H, Kawashima, Y, Mejia, W, Wu, Y, Rosen, CJ, Panus, D, Bouxsein, M, Majeska, RJ, Schaffler, MB & Yakar, S 2010, 'Growth hormone protects against ovariectomy-induced bone loss in states of low circulating Insulin-like Growth Factor (IGF-1)', Journal of Bone and Mineral Research, vol. 25, no. 2, pp. 235-246. https://doi.org/10.1359/jbmr.090723
Fritton, J. Christopher ; Emerton, Kelly B. ; Sun, Hui ; Kawashima, Yuki ; Mejia, Wilson ; Wu, Yingjie ; Rosen, Clifford J. ; Panus, David ; Bouxsein, Mary ; Majeska, Robert J. ; Schaffler, Mitchell B. ; Yakar, Shoshana. / Growth hormone protects against ovariectomy-induced bone loss in states of low circulating Insulin-like Growth Factor (IGF-1). In: Journal of Bone and Mineral Research. 2010 ; Vol. 25, No. 2. pp. 235-246.
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