Growth factor signaling and memory formation

Temporal and spatial integration of a molecular network

Ashley M. Kopec, Thomas Carew

Research output: Contribution to journalArticle

Abstract

Growth factor (GF) signaling is critically important for developmental plasticity. It also plays a crucial role in adult plasticity, such as that required for memory formation. Although different GFs interact with receptors containing distinct types of kinase domains, they typically signal through converging intracellular cascades (e.g., Ras-MEK-MAPK) to mediate overlapping functional endpoints. Several GFs have been implicated in memory formation, but due to a high level of convergent signaling, the unique contributions of individual GFs as well as the interactions between GF signaling cascades during the induction of memory is not well known. In this review, we highlight the unique roles of specific GFs in dendritic plasticity, and discuss the spatial and temporal profiles of different GFs during memory formation. Collectively, the data suggest that the roles of GF signaling in long-lasting behavioral and structural plasticity may be best viewed as interactive components in a complex molecular network.

Original languageEnglish (US)
Pages (from-to)531-539
Number of pages9
JournalLearning and Memory
Volume20
Issue number10
DOIs
StatePublished - Oct 2013

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Intercellular Signaling Peptides and Proteins
Mitogen-Activated Protein Kinase Kinases
Phosphotransferases

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Neuropsychology and Physiological Psychology

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Growth factor signaling and memory formation : Temporal and spatial integration of a molecular network. / Kopec, Ashley M.; Carew, Thomas.

In: Learning and Memory, Vol. 20, No. 10, 10.2013, p. 531-539.

Research output: Contribution to journalArticle

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