Glycolytic concomitant of brain inflammation produced by goldthioglucose

Richard J. Dirocco, Edgar Coons

Research output: Contribution to journalArticle

Abstract

In order to determine the effect of inflammation on brain glycolysis in the absence of leukocyte infiltration, [14C]deoxyglucose autoradiography and hematoxylin-eosin (HE) counter-staining were applied to mice at various times after the induction of chemotoxic inflammatory brain lesions by the systemic administration of goldthioglucose. Glycolysis was intensely stimulated in affected circumventricular organs, without cellular infiltration. This result is consistent with the activation of anaerobic glycolysis by inflammatory sequelae that culminate in ischemic hypoxia in the lesion sites.

Original languageEnglish (US)
Pages (from-to)313-317
Number of pages5
JournalBrain Research
Volume336
Issue number2
DOIs
StatePublished - Jun 17 1985

Fingerprint

Glycolysis
Encephalitis
Deoxyglucose
Hematoxylin
Eosine Yellowish-(YS)
Autoradiography
Leukocytes
Staining and Labeling
Brain

Keywords

  • anearobic glycolysis
  • blood
  • brain barrier
  • goldthioglucose
  • inflammation
  • ischemia
  • multiple sclerosis
  • trauma
  • [C]deoxyglucose autoradiography

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Glycolytic concomitant of brain inflammation produced by goldthioglucose. / Dirocco, Richard J.; Coons, Edgar.

In: Brain Research, Vol. 336, No. 2, 17.06.1985, p. 313-317.

Research output: Contribution to journalArticle

Dirocco, Richard J. ; Coons, Edgar. / Glycolytic concomitant of brain inflammation produced by goldthioglucose. In: Brain Research. 1985 ; Vol. 336, No. 2. pp. 313-317.
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