Abstract
In order to determine the effect of inflammation on brain glycolysis in the absence of leukocyte infiltration, [14C]deoxyglucose autoradiography and hematoxylin-eosin (HE) counter-staining were applied to mice at various times after the induction of chemotoxic inflammatory brain lesions by the systemic administration of goldthioglucose. Glycolysis was intensely stimulated in affected circumventricular organs, without cellular infiltration. This result is consistent with the activation of anaerobic glycolysis by inflammatory sequelae that culminate in ischemic hypoxia in the lesion sites.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 313-317 |
| Number of pages | 5 |
| Journal | Brain Research |
| Volume | 336 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 17 1985 |
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Keywords
- anearobic glycolysis
- blood
- brain barrier
- goldthioglucose
- inflammation
- ischemia
- multiple sclerosis
- trauma
- [C]deoxyglucose autoradiography
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
Cite this
Glycolytic concomitant of brain inflammation produced by goldthioglucose. / Dirocco, Richard J.; Coons, Edgar.
In: Brain Research, Vol. 336, No. 2, 17.06.1985, p. 313-317.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Glycolytic concomitant of brain inflammation produced by goldthioglucose
AU - Dirocco, Richard J.
AU - Coons, Edgar
PY - 1985/6/17
Y1 - 1985/6/17
N2 - In order to determine the effect of inflammation on brain glycolysis in the absence of leukocyte infiltration, [14C]deoxyglucose autoradiography and hematoxylin-eosin (HE) counter-staining were applied to mice at various times after the induction of chemotoxic inflammatory brain lesions by the systemic administration of goldthioglucose. Glycolysis was intensely stimulated in affected circumventricular organs, without cellular infiltration. This result is consistent with the activation of anaerobic glycolysis by inflammatory sequelae that culminate in ischemic hypoxia in the lesion sites.
AB - In order to determine the effect of inflammation on brain glycolysis in the absence of leukocyte infiltration, [14C]deoxyglucose autoradiography and hematoxylin-eosin (HE) counter-staining were applied to mice at various times after the induction of chemotoxic inflammatory brain lesions by the systemic administration of goldthioglucose. Glycolysis was intensely stimulated in affected circumventricular organs, without cellular infiltration. This result is consistent with the activation of anaerobic glycolysis by inflammatory sequelae that culminate in ischemic hypoxia in the lesion sites.
KW - anearobic glycolysis
KW - blood
KW - brain barrier
KW - goldthioglucose
KW - inflammation
KW - ischemia
KW - multiple sclerosis
KW - trauma
KW - [C]deoxyglucose autoradiography
UR - http://www.scopus.com/inward/record.url?scp=0022254367&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022254367&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(85)90658-4
DO - 10.1016/0006-8993(85)90658-4
M3 - Article
C2 - 3924344
AN - SCOPUS:0022254367
VL - 336
SP - 313
EP - 317
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 2
ER -