Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

Xi He, Jean-Pierre Saint-Jeannet, James R. Woodgett, Harold E. Varmus, Igor B. Dawid

Research output: Contribution to journalArticle

Abstract

Glycogen synthase kinase 3 (GSK-3) is homologous to the product of the Drosophila gene shaggy (zeste-white 3), which is required for signalling by wingless during Drosophila development. To test whether GSK-3 is also involved in vertebrate pattern formation, its role was investigated during early Xenopus development. It was found that dominant-negative GSK-3 mutants induced dorsal differentiation, whereas wild-type GSK-3 induced ventralization. These results indicate that GSK-3 is required for ventral differentiation, and suggest that dorsal differentiation may involve the suppression of GSK-3 activity by a wingless/wnt-related signal.

Original languageEnglish (US)
Pages (from-to)617-622
Number of pages6
JournalNature
Volume374
Issue number6523
StatePublished - 1995

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Glycogen Synthase Kinase 3
Xenopus
Embryonic Structures
Drosophila
Vertebrates
Genes

ASJC Scopus subject areas

  • General

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He, X., Saint-Jeannet, J-P., Woodgett, J. R., Varmus, H. E., & Dawid, I. B. (1995). Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos. Nature, 374(6523), 617-622.

Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos. / He, Xi; Saint-Jeannet, Jean-Pierre; Woodgett, James R.; Varmus, Harold E.; Dawid, Igor B.

In: Nature, Vol. 374, No. 6523, 1995, p. 617-622.

Research output: Contribution to journalArticle

He, X, Saint-Jeannet, J-P, Woodgett, JR, Varmus, HE & Dawid, IB 1995, 'Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos', Nature, vol. 374, no. 6523, pp. 617-622.
He X, Saint-Jeannet J-P, Woodgett JR, Varmus HE, Dawid IB. Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos. Nature. 1995;374(6523):617-622.
He, Xi ; Saint-Jeannet, Jean-Pierre ; Woodgett, James R. ; Varmus, Harold E. ; Dawid, Igor B. / Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos. In: Nature. 1995 ; Vol. 374, No. 6523. pp. 617-622.
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