Glucose sensing using dual-gated BioFETs with 5nm-thick silicon body

Ting Wu, Ali Afzali, Kae Dyi You, Kim Kisslinger, Eric Stach, Davood Shahrjerdi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Field-effect transistors (FETs) are commonly used as affinity-based electrical transducers, known as bioFETs. These sensors are, however, unable to directly detect uncharged molecules such as glucose, necessitating the use of ligand molecules. Further, the change of the electrical signal resulting from the biochemical reactions is often small. In the past decade, significant research was done to enhance the sensitivity of bioFETs using nanowire1 and nanoribbon structures. Recently, dual-gated bioFETs were also shown to exceed the Nernst limit of 59mV/pH using capacitive coupling3,4. Here, we introduce a new ligand molecule for the direct detection of glucose using bioFETs. We demonstrate the amplification of the electrical signal originating from the glucose reaction using our 'engineered' dual-gated bioFETs featuring ultra-thin silicon body and buried oxide of 5nm and 10nm, respectively.

Original languageEnglish (US)
Title of host publication75th Annual Device Research Conference, DRC 2017
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781509063277
DOIs
StatePublished - Aug 1 2017
Event75th Annual Device Research Conference, DRC 2017 - South Bend, United States
Duration: Jun 25 2017Jun 28 2017

Other

Other75th Annual Device Research Conference, DRC 2017
CountryUnited States
CitySouth Bend
Period6/25/176/28/17

Fingerprint

Glucose
Silicon
Molecules
Ligands
Nanoribbons
Field effect transistors
Amplification
Transducers
Oxides
Sensors

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

Cite this

Wu, T., Afzali, A., You, K. D., Kisslinger, K., Stach, E., & Shahrjerdi, D. (2017). Glucose sensing using dual-gated BioFETs with 5nm-thick silicon body. In 75th Annual Device Research Conference, DRC 2017 [7999421] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/DRC.2017.7999421

Glucose sensing using dual-gated BioFETs with 5nm-thick silicon body. / Wu, Ting; Afzali, Ali; You, Kae Dyi; Kisslinger, Kim; Stach, Eric; Shahrjerdi, Davood.

75th Annual Device Research Conference, DRC 2017. Institute of Electrical and Electronics Engineers Inc., 2017. 7999421.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wu, T, Afzali, A, You, KD, Kisslinger, K, Stach, E & Shahrjerdi, D 2017, Glucose sensing using dual-gated BioFETs with 5nm-thick silicon body. in 75th Annual Device Research Conference, DRC 2017., 7999421, Institute of Electrical and Electronics Engineers Inc., 75th Annual Device Research Conference, DRC 2017, South Bend, United States, 6/25/17. https://doi.org/10.1109/DRC.2017.7999421
Wu T, Afzali A, You KD, Kisslinger K, Stach E, Shahrjerdi D. Glucose sensing using dual-gated BioFETs with 5nm-thick silicon body. In 75th Annual Device Research Conference, DRC 2017. Institute of Electrical and Electronics Engineers Inc. 2017. 7999421 https://doi.org/10.1109/DRC.2017.7999421
Wu, Ting ; Afzali, Ali ; You, Kae Dyi ; Kisslinger, Kim ; Stach, Eric ; Shahrjerdi, Davood. / Glucose sensing using dual-gated BioFETs with 5nm-thick silicon body. 75th Annual Device Research Conference, DRC 2017. Institute of Electrical and Electronics Engineers Inc., 2017.
@inproceedings{ff3675a1f12c492797fba009fe47407c,
title = "Glucose sensing using dual-gated BioFETs with 5nm-thick silicon body",
abstract = "Field-effect transistors (FETs) are commonly used as affinity-based electrical transducers, known as bioFETs. These sensors are, however, unable to directly detect uncharged molecules such as glucose, necessitating the use of ligand molecules. Further, the change of the electrical signal resulting from the biochemical reactions is often small. In the past decade, significant research was done to enhance the sensitivity of bioFETs using nanowire1 and nanoribbon structures. Recently, dual-gated bioFETs were also shown to exceed the Nernst limit of 59mV/pH using capacitive coupling3,4. Here, we introduce a new ligand molecule for the direct detection of glucose using bioFETs. We demonstrate the amplification of the electrical signal originating from the glucose reaction using our 'engineered' dual-gated bioFETs featuring ultra-thin silicon body and buried oxide of 5nm and 10nm, respectively.",
author = "Ting Wu and Ali Afzali and You, {Kae Dyi} and Kim Kisslinger and Eric Stach and Davood Shahrjerdi",
year = "2017",
month = "8",
day = "1",
doi = "10.1109/DRC.2017.7999421",
language = "English (US)",
booktitle = "75th Annual Device Research Conference, DRC 2017",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
address = "United States",

}

TY - GEN

T1 - Glucose sensing using dual-gated BioFETs with 5nm-thick silicon body

AU - Wu, Ting

AU - Afzali, Ali

AU - You, Kae Dyi

AU - Kisslinger, Kim

AU - Stach, Eric

AU - Shahrjerdi, Davood

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Field-effect transistors (FETs) are commonly used as affinity-based electrical transducers, known as bioFETs. These sensors are, however, unable to directly detect uncharged molecules such as glucose, necessitating the use of ligand molecules. Further, the change of the electrical signal resulting from the biochemical reactions is often small. In the past decade, significant research was done to enhance the sensitivity of bioFETs using nanowire1 and nanoribbon structures. Recently, dual-gated bioFETs were also shown to exceed the Nernst limit of 59mV/pH using capacitive coupling3,4. Here, we introduce a new ligand molecule for the direct detection of glucose using bioFETs. We demonstrate the amplification of the electrical signal originating from the glucose reaction using our 'engineered' dual-gated bioFETs featuring ultra-thin silicon body and buried oxide of 5nm and 10nm, respectively.

AB - Field-effect transistors (FETs) are commonly used as affinity-based electrical transducers, known as bioFETs. These sensors are, however, unable to directly detect uncharged molecules such as glucose, necessitating the use of ligand molecules. Further, the change of the electrical signal resulting from the biochemical reactions is often small. In the past decade, significant research was done to enhance the sensitivity of bioFETs using nanowire1 and nanoribbon structures. Recently, dual-gated bioFETs were also shown to exceed the Nernst limit of 59mV/pH using capacitive coupling3,4. Here, we introduce a new ligand molecule for the direct detection of glucose using bioFETs. We demonstrate the amplification of the electrical signal originating from the glucose reaction using our 'engineered' dual-gated bioFETs featuring ultra-thin silicon body and buried oxide of 5nm and 10nm, respectively.

UR - http://www.scopus.com/inward/record.url?scp=85028030567&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028030567&partnerID=8YFLogxK

U2 - 10.1109/DRC.2017.7999421

DO - 10.1109/DRC.2017.7999421

M3 - Conference contribution

BT - 75th Annual Device Research Conference, DRC 2017

PB - Institute of Electrical and Electronics Engineers Inc.

ER -