Glia relay differentiation cues to coordinate neuronal development in Drosophila

Vilaiwan M. Fernandes, Zhenqing Chen, Anthony M. Rossi, Jaqueline Zipfel, Claude Desplan

Research output: Contribution to journalArticle

Abstract

Neuronal birth and specification must be coordinated across the developing brain to generate the neurons that constitute neural circuits. We used the Drosophila visual system to investigate how development is coordinated to establish retinotopy, a feature of all visual systems. Photoreceptors achieve retinotopy by inducing their target field in the optic lobe, the lamina neurons, with a secreted differentiation cue, epidermal growth factor (EGF). We find that communication between photoreceptors and lamina cells requires a signaling relay through glia. In response to photoreceptor-EGF, glia produce insulin-like peptides, which induce lamina neuronal differentiation. Our study identifies a role for glia in coordinating neuronal development across distinct brain regions, thus reconciling the timing of column assembly with that of delayed differentiation, as well as the spatiotemporal pattern of lamina neuron differentiation.

Original languageEnglish (US)
Pages (from-to)886-891
Number of pages6
JournalScience
Volume357
Issue number6354
DOIs
StatePublished - Sep 1 2017

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Neuroglia
Drosophila
Cues
Neurons
Epidermal Growth Factor
Photoreceptor Cells
Brain
Communication
Parturition
Insulin
Peptides

ASJC Scopus subject areas

  • Medicine(all)
  • General

Cite this

Glia relay differentiation cues to coordinate neuronal development in Drosophila. / Fernandes, Vilaiwan M.; Chen, Zhenqing; Rossi, Anthony M.; Zipfel, Jaqueline; Desplan, Claude.

In: Science, Vol. 357, No. 6354, 01.09.2017, p. 886-891.

Research output: Contribution to journalArticle

Fernandes, Vilaiwan M. ; Chen, Zhenqing ; Rossi, Anthony M. ; Zipfel, Jaqueline ; Desplan, Claude. / Glia relay differentiation cues to coordinate neuronal development in Drosophila. In: Science. 2017 ; Vol. 357, No. 6354. pp. 886-891.
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