Gingival enlargement as a manifestation of tuberous sclerosis: Case report and periodontal management

Urszula B. Korol, Robert Schoor, Veena Nanda, Khalid Almas, Joan A. Phelan

Research output: Contribution to journalArticle

Abstract

Background: Tuberous sclerosis is an autosomal-dominant inherited disease involving many organs of the body. Oral manifestations include gingival enlargement, fibromas, and dental enamel pitting. Thereport presents a case of tuberous sclerosis with gingival enlargement histologically consistent with angiofibroma, describes its successful periodontal management, and reviews the literature associated with oral manifestations of tuberous sclerosis. Methods: A 26-year-old white male presented to the Department of Periodontics and Implant Dentistry, New York University College of Dentistry, with a diagnosis of tuberous sclerosis and a chief complaint of gingival enlargement affecting mastication and esthetics. Following a complete medical history review, consultation with the patient's medical team at New York University Medical Center, and a thorough oral and periodontal examination, a treatment plan was developed that included oral hygiene instructions, mechanical debridement, and periodontal reevaluation. This was followed by gingivectomy, which provided improved function and esthetics. Excised tissue was submitted for histologic examination. The patient was followed every 2 months for assessment of the outcome of the surgical treatment. An extensive search of the dental and dermatologic literature was performed on MEDLINE. Results: Histologic examination of the gingival tissue revealed features consistent with angiofibroma. Fifteen months following gingivectomy, the contours and gingival surface appearance remained normal. Conclusions: The gingival enlargement was histologically consistent with the characteristic angiofibromas of tuberous sclerosis. The gingival enlargement responded very well to gingivectomy and periodontal maintenance.

Original languageEnglish (US)
Pages (from-to)759-763
Number of pages5
JournalJournal of Periodontology
Volume79
Issue number4
DOIs
StatePublished - Apr 2008

Fingerprint

Tuberous Sclerosis
Gingivectomy
Angiofibroma
Oral Manifestations
Dentistry
Esthetics
Periodontal Debridement
Periodontics
faropenem medoxomil
Oral Diagnosis
Fibroma
Oral Hygiene
Mastication
Dental Enamel
MEDLINE
Tooth
Referral and Consultation
Maintenance
Outcome Assessment (Health Care)

Keywords

  • Case report
  • Gingival enlargement
  • Gingivectomy
  • Neurocutaneous syndromes
  • Tuberous sclerosis

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Gingival enlargement as a manifestation of tuberous sclerosis : Case report and periodontal management. / Korol, Urszula B.; Schoor, Robert; Nanda, Veena; Almas, Khalid; Phelan, Joan A.

In: Journal of Periodontology, Vol. 79, No. 4, 04.2008, p. 759-763.

Research output: Contribution to journalArticle

Korol, Urszula B. ; Schoor, Robert ; Nanda, Veena ; Almas, Khalid ; Phelan, Joan A. / Gingival enlargement as a manifestation of tuberous sclerosis : Case report and periodontal management. In: Journal of Periodontology. 2008 ; Vol. 79, No. 4. pp. 759-763.
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