Ghrelin gene expression is age-dependent and influenced by gender and the level of circulating IGF-I

Ye Lauren Liu, Shoshana Yakar, Veronica Otero-Corchon, Malcolm J. Low, Jun Li Liu

Research output: Contribution to journalArticle

Abstract

Ghrelin activates GH release and is implicated in growth and metabolic regulation. The regulation of its biosynthesis has not been well studied. The current investigation was designed to examine some of the factors that may influence ghrelin gene expression in the stomach. Thus, in C57BL/6 mice, ghrelin mRNA was detectable by Northern blots throughout the age groups studied, but the levels changed markedly over time. Levels were low at E18.5 and increased rapidly after birth to 6-fold at P14 before peaking to 8-fold at P21. The levels then exhibited a gradual decline at P60 (75% of the peak level) and at 6 months (67%) and a drastic decrease as the animals aged to 19 months (only 5%). Furthermore, sexual dimorphic gene expression, the effect of liver-derived IGF-I deficiency, as well as ghrelin secretion were studied. Our results support a role of ghrelin in growth/metabolism in juvenile and young adult mice of both sexes and in sexually dimorphic regulation of GH secretion in aged mice.

Original languageEnglish (US)
Pages (from-to)97-103
Number of pages7
JournalMolecular and Cellular Endocrinology
Volume189
Issue number1-2
DOIs
StatePublished - Mar 28 2002

Fingerprint

Ghrelin
Insulin-Like Growth Factor I
Gene expression
Gene Expression
Biosynthesis
Growth
Inbred C57BL Mouse
Metabolism
Northern Blotting
Liver
Young Adult
Stomach
Animals
Age Groups
Parturition
Messenger RNA

Keywords

  • Age-dependence
  • Gender
  • Ghrelin mRNA
  • IGF-I

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Ghrelin gene expression is age-dependent and influenced by gender and the level of circulating IGF-I. / Liu, Ye Lauren; Yakar, Shoshana; Otero-Corchon, Veronica; Low, Malcolm J.; Liu, Jun Li.

In: Molecular and Cellular Endocrinology, Vol. 189, No. 1-2, 28.03.2002, p. 97-103.

Research output: Contribution to journalArticle

Liu, Ye Lauren ; Yakar, Shoshana ; Otero-Corchon, Veronica ; Low, Malcolm J. ; Liu, Jun Li. / Ghrelin gene expression is age-dependent and influenced by gender and the level of circulating IGF-I. In: Molecular and Cellular Endocrinology. 2002 ; Vol. 189, No. 1-2. pp. 97-103.
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