Geographical genomics of human leukocyte gene expression variation in southern Morocco

Youssef Idaghdhour, Wendy Czika, Kevin V. Shianna, Sang H. Lee, Peter M. Visscher, Hilary C. Martin, Kelci Miclaus, Sami J. Jadallah, David B. Goldstein, Russell D. Wolfinger, Greg Gibson

    Research output: Contribution to journalArticle

    Abstract

    Studies of the genetics of gene expression can identify expression SNPs (eSNPs) that explain variation in transcript abundance. Here we address the robustness of eSNP associations to environmental geography and population structure in a comparison of 194 Arab and Amazigh individuals from a city and two villages in southern Morocco. Gene expression differed between pairs of locations for up to a third of all transcripts, with notable enrichment of transcripts involved in ribosomal biosynthesis and oxidative phosphorylation. Robust associations were observed in the leukocyte samples: cis eSNPs (P <10 -08) were identified for 346 genes, and trans eSNPs (P <10 -11) for 10 genes. All of these associations were consistent both across the three sample locations and after controlling for ancestry and relatedness. No evidence of large-effect trans-acting mediators of the pervasive environmental influence was found; instead, genetic and environmental factors acted in a largely additive manner.

    Original languageEnglish (US)
    Pages (from-to)62-67
    Number of pages6
    JournalNature Genetics
    Volume42
    Issue number1
    DOIs
    StatePublished - Jan 1 2010

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    Morocco
    Genomics
    Single Nucleotide Polymorphism
    Leukocytes
    Gene Expression
    Geography
    Oxidative Phosphorylation
    Population
    Genes

    ASJC Scopus subject areas

    • Genetics

    Cite this

    Idaghdhour, Y., Czika, W., Shianna, K. V., Lee, S. H., Visscher, P. M., Martin, H. C., ... Gibson, G. (2010). Geographical genomics of human leukocyte gene expression variation in southern Morocco. Nature Genetics, 42(1), 62-67. https://doi.org/10.1038/ng.495

    Geographical genomics of human leukocyte gene expression variation in southern Morocco. / Idaghdhour, Youssef; Czika, Wendy; Shianna, Kevin V.; Lee, Sang H.; Visscher, Peter M.; Martin, Hilary C.; Miclaus, Kelci; Jadallah, Sami J.; Goldstein, David B.; Wolfinger, Russell D.; Gibson, Greg.

    In: Nature Genetics, Vol. 42, No. 1, 01.01.2010, p. 62-67.

    Research output: Contribution to journalArticle

    Idaghdhour, Y, Czika, W, Shianna, KV, Lee, SH, Visscher, PM, Martin, HC, Miclaus, K, Jadallah, SJ, Goldstein, DB, Wolfinger, RD & Gibson, G 2010, 'Geographical genomics of human leukocyte gene expression variation in southern Morocco', Nature Genetics, vol. 42, no. 1, pp. 62-67. https://doi.org/10.1038/ng.495
    Idaghdhour Y, Czika W, Shianna KV, Lee SH, Visscher PM, Martin HC et al. Geographical genomics of human leukocyte gene expression variation in southern Morocco. Nature Genetics. 2010 Jan 1;42(1):62-67. https://doi.org/10.1038/ng.495
    Idaghdhour, Youssef ; Czika, Wendy ; Shianna, Kevin V. ; Lee, Sang H. ; Visscher, Peter M. ; Martin, Hilary C. ; Miclaus, Kelci ; Jadallah, Sami J. ; Goldstein, David B. ; Wolfinger, Russell D. ; Gibson, Greg. / Geographical genomics of human leukocyte gene expression variation in southern Morocco. In: Nature Genetics. 2010 ; Vol. 42, No. 1. pp. 62-67.
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