Genomics via optical mapping. III: Contiging genomic DNA.

T. Anantharaman, Bhubaneswar Mishra, D. Schwartz

Research output: Contribution to journalArticle

Abstract

In this paper, we describe our algorithmic approach to constructing an alignment of (contiging) a set of restriction maps created from the images of individual genomic (uncloned) DNA molecules digested by restriction enzymes. Generally, these DNA segments are sized in the range of 1-4 Mb. The goal is to devise contiging algorithms capable of producing high-quality composite maps rapidly and in a scaleable manner. The resulting software is a key component of our physical mapping automation tools and has been used to create complete maps of various microorganisms (E. coli, P. falciparum and D. radiodurans). Experimental results match known sequence data.

Fingerprint

Genomics
Automation
DNA
Software
Escherichia coli
Enzymes

Cite this

@article{c847c8cf7a384bcab32a732821334a75,
title = "Genomics via optical mapping. III: Contiging genomic DNA.",
abstract = "In this paper, we describe our algorithmic approach to constructing an alignment of (contiging) a set of restriction maps created from the images of individual genomic (uncloned) DNA molecules digested by restriction enzymes. Generally, these DNA segments are sized in the range of 1-4 Mb. The goal is to devise contiging algorithms capable of producing high-quality composite maps rapidly and in a scaleable manner. The resulting software is a key component of our physical mapping automation tools and has been used to create complete maps of various microorganisms (E. coli, P. falciparum and D. radiodurans). Experimental results match known sequence data.",
author = "T. Anantharaman and Bhubaneswar Mishra and D. Schwartz",
year = "1999",
language = "English (US)",
pages = "18--27",
journal = "Proceedings / . International Conference on Intelligent Systems for Molecular Biology ; ISMB. International Conference on Intelligent Systems for Molecular Biology",
issn = "1553-0833",
publisher = "American Association for Artificial Intelligence (AAAI) Press",

}

TY - JOUR

T1 - Genomics via optical mapping. III

T2 - Contiging genomic DNA.

AU - Anantharaman, T.

AU - Mishra, Bhubaneswar

AU - Schwartz, D.

PY - 1999

Y1 - 1999

N2 - In this paper, we describe our algorithmic approach to constructing an alignment of (contiging) a set of restriction maps created from the images of individual genomic (uncloned) DNA molecules digested by restriction enzymes. Generally, these DNA segments are sized in the range of 1-4 Mb. The goal is to devise contiging algorithms capable of producing high-quality composite maps rapidly and in a scaleable manner. The resulting software is a key component of our physical mapping automation tools and has been used to create complete maps of various microorganisms (E. coli, P. falciparum and D. radiodurans). Experimental results match known sequence data.

AB - In this paper, we describe our algorithmic approach to constructing an alignment of (contiging) a set of restriction maps created from the images of individual genomic (uncloned) DNA molecules digested by restriction enzymes. Generally, these DNA segments are sized in the range of 1-4 Mb. The goal is to devise contiging algorithms capable of producing high-quality composite maps rapidly and in a scaleable manner. The resulting software is a key component of our physical mapping automation tools and has been used to create complete maps of various microorganisms (E. coli, P. falciparum and D. radiodurans). Experimental results match known sequence data.

UR - http://www.scopus.com/inward/record.url?scp=0033288774&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033288774&partnerID=8YFLogxK

M3 - Article

SP - 18

EP - 27

JO - Proceedings / . International Conference on Intelligent Systems for Molecular Biology ; ISMB. International Conference on Intelligent Systems for Molecular Biology

JF - Proceedings / . International Conference on Intelligent Systems for Molecular Biology ; ISMB. International Conference on Intelligent Systems for Molecular Biology

SN - 1553-0833

ER -