Genome-wide association meta- A nalysis of 78,308 individuals identifies new loci and genes influencing human intelligence

Suzanne Sniekers, Sven Stringer, Kyoko Watanabe, Philip R. Jansen, Jonathan R.I. Coleman, Eva Krapohl, Erdogan Taskesen, Anke R. Hammerschlag, Aysu Okbay, Delilah Zabaneh, Najaf Amin, Gerome Breen, David Cesarini, Christopher F. Chabris, William G. Iacono, M. Arfan Ikram, Magnus Johannesson, Philipp Koellinger, James J. Lee, Patrik K.E. Magnusson & 10 others Matt McGue, Mike B. Miller, William E.R. Ollier, Antony Payton, Neil Pendleton, Robert Plomin, Cornelius A. Rietveld, Henning Tiemeier, Cornelia M. Van Duijn, Danielle Posthuma

    Research output: Contribution to journalArticle

    Abstract

    Intelligence is associated with important economic and health-related life outcomes. Despite intelligence having substantial heritability (0.54) and a confirmed polygenic nature, initial genetic studies were mostly underpowered. Here we report a meta- A nalysis for intelligence of 78,308 individuals. We identify 336 associated SNPs (METAL P < 5 × 10-8) in 18 genomic loci, of which 15 are new. Around half of the SNPs are located inside a gene, implicating 22 genes, of which 11 are new findings. Gene-based analyses identified an additional 30 genes (MAGMA P < 2.73 × 10-6), of which all but one had not been implicated previously. We show that the identified genes are predominantly expressed in brain tissue, and pathway analysis indicates the involvement of genes regulating cell development (MAGMA competitive P = 3.5 × 10-6). Despite the well-known difference in twin-based heritability for intelligence in childhood (0.45) and adulthood (0.80), we show substantial genetic correlation (rg = 0.89, LD score regression P = 5.4 × 10-29). These findings provide new insight into the genetic architecture of intelligence.

    Original languageEnglish (US)
    Pages (from-to)1107-1112
    Number of pages6
    JournalNature Genetics
    Volume49
    Issue number7
    DOIs
    StatePublished - Jul 1 2017

    Fingerprint

    Intelligence
    Genome
    Genes
    Single Nucleotide Polymorphism
    Economics
    Health
    Brain

    ASJC Scopus subject areas

    • Genetics

    Cite this

    Sniekers, S., Stringer, S., Watanabe, K., Jansen, P. R., Coleman, J. R. I., Krapohl, E., ... Posthuma, D. (2017). Genome-wide association meta- A nalysis of 78,308 individuals identifies new loci and genes influencing human intelligence. Nature Genetics, 49(7), 1107-1112. https://doi.org/10.1038/ng.3869

    Genome-wide association meta- A nalysis of 78,308 individuals identifies new loci and genes influencing human intelligence. / Sniekers, Suzanne; Stringer, Sven; Watanabe, Kyoko; Jansen, Philip R.; Coleman, Jonathan R.I.; Krapohl, Eva; Taskesen, Erdogan; Hammerschlag, Anke R.; Okbay, Aysu; Zabaneh, Delilah; Amin, Najaf; Breen, Gerome; Cesarini, David; Chabris, Christopher F.; Iacono, William G.; Ikram, M. Arfan; Johannesson, Magnus; Koellinger, Philipp; Lee, James J.; Magnusson, Patrik K.E.; McGue, Matt; Miller, Mike B.; Ollier, William E.R.; Payton, Antony; Pendleton, Neil; Plomin, Robert; Rietveld, Cornelius A.; Tiemeier, Henning; Van Duijn, Cornelia M.; Posthuma, Danielle.

    In: Nature Genetics, Vol. 49, No. 7, 01.07.2017, p. 1107-1112.

    Research output: Contribution to journalArticle

    Sniekers, S, Stringer, S, Watanabe, K, Jansen, PR, Coleman, JRI, Krapohl, E, Taskesen, E, Hammerschlag, AR, Okbay, A, Zabaneh, D, Amin, N, Breen, G, Cesarini, D, Chabris, CF, Iacono, WG, Ikram, MA, Johannesson, M, Koellinger, P, Lee, JJ, Magnusson, PKE, McGue, M, Miller, MB, Ollier, WER, Payton, A, Pendleton, N, Plomin, R, Rietveld, CA, Tiemeier, H, Van Duijn, CM & Posthuma, D 2017, 'Genome-wide association meta- A nalysis of 78,308 individuals identifies new loci and genes influencing human intelligence', Nature Genetics, vol. 49, no. 7, pp. 1107-1112. https://doi.org/10.1038/ng.3869
    Sniekers, Suzanne ; Stringer, Sven ; Watanabe, Kyoko ; Jansen, Philip R. ; Coleman, Jonathan R.I. ; Krapohl, Eva ; Taskesen, Erdogan ; Hammerschlag, Anke R. ; Okbay, Aysu ; Zabaneh, Delilah ; Amin, Najaf ; Breen, Gerome ; Cesarini, David ; Chabris, Christopher F. ; Iacono, William G. ; Ikram, M. Arfan ; Johannesson, Magnus ; Koellinger, Philipp ; Lee, James J. ; Magnusson, Patrik K.E. ; McGue, Matt ; Miller, Mike B. ; Ollier, William E.R. ; Payton, Antony ; Pendleton, Neil ; Plomin, Robert ; Rietveld, Cornelius A. ; Tiemeier, Henning ; Van Duijn, Cornelia M. ; Posthuma, Danielle. / Genome-wide association meta- A nalysis of 78,308 individuals identifies new loci and genes influencing human intelligence. In: Nature Genetics. 2017 ; Vol. 49, No. 7. pp. 1107-1112.
    @article{7ba883a18f674b2bb9ec7d3ccd2e4224,
    title = "Genome-wide association meta- A nalysis of 78,308 individuals identifies new loci and genes influencing human intelligence",
    abstract = "Intelligence is associated with important economic and health-related life outcomes. Despite intelligence having substantial heritability (0.54) and a confirmed polygenic nature, initial genetic studies were mostly underpowered. Here we report a meta- A nalysis for intelligence of 78,308 individuals. We identify 336 associated SNPs (METAL P < 5 × 10-8) in 18 genomic loci, of which 15 are new. Around half of the SNPs are located inside a gene, implicating 22 genes, of which 11 are new findings. Gene-based analyses identified an additional 30 genes (MAGMA P < 2.73 × 10-6), of which all but one had not been implicated previously. We show that the identified genes are predominantly expressed in brain tissue, and pathway analysis indicates the involvement of genes regulating cell development (MAGMA competitive P = 3.5 × 10-6). Despite the well-known difference in twin-based heritability for intelligence in childhood (0.45) and adulthood (0.80), we show substantial genetic correlation (rg = 0.89, LD score regression P = 5.4 × 10-29). These findings provide new insight into the genetic architecture of intelligence.",
    author = "Suzanne Sniekers and Sven Stringer and Kyoko Watanabe and Jansen, {Philip R.} and Coleman, {Jonathan R.I.} and Eva Krapohl and Erdogan Taskesen and Hammerschlag, {Anke R.} and Aysu Okbay and Delilah Zabaneh and Najaf Amin and Gerome Breen and David Cesarini and Chabris, {Christopher F.} and Iacono, {William G.} and Ikram, {M. Arfan} and Magnus Johannesson and Philipp Koellinger and Lee, {James J.} and Magnusson, {Patrik K.E.} and Matt McGue and Miller, {Mike B.} and Ollier, {William E.R.} and Antony Payton and Neil Pendleton and Robert Plomin and Rietveld, {Cornelius A.} and Henning Tiemeier and {Van Duijn}, {Cornelia M.} and Danielle Posthuma",
    year = "2017",
    month = "7",
    day = "1",
    doi = "10.1038/ng.3869",
    language = "English (US)",
    volume = "49",
    pages = "1107--1112",
    journal = "Nature Genetics",
    issn = "1061-4036",
    publisher = "Nature Publishing Group",
    number = "7",

    }

    TY - JOUR

    T1 - Genome-wide association meta- A nalysis of 78,308 individuals identifies new loci and genes influencing human intelligence

    AU - Sniekers, Suzanne

    AU - Stringer, Sven

    AU - Watanabe, Kyoko

    AU - Jansen, Philip R.

    AU - Coleman, Jonathan R.I.

    AU - Krapohl, Eva

    AU - Taskesen, Erdogan

    AU - Hammerschlag, Anke R.

    AU - Okbay, Aysu

    AU - Zabaneh, Delilah

    AU - Amin, Najaf

    AU - Breen, Gerome

    AU - Cesarini, David

    AU - Chabris, Christopher F.

    AU - Iacono, William G.

    AU - Ikram, M. Arfan

    AU - Johannesson, Magnus

    AU - Koellinger, Philipp

    AU - Lee, James J.

    AU - Magnusson, Patrik K.E.

    AU - McGue, Matt

    AU - Miller, Mike B.

    AU - Ollier, William E.R.

    AU - Payton, Antony

    AU - Pendleton, Neil

    AU - Plomin, Robert

    AU - Rietveld, Cornelius A.

    AU - Tiemeier, Henning

    AU - Van Duijn, Cornelia M.

    AU - Posthuma, Danielle

    PY - 2017/7/1

    Y1 - 2017/7/1

    N2 - Intelligence is associated with important economic and health-related life outcomes. Despite intelligence having substantial heritability (0.54) and a confirmed polygenic nature, initial genetic studies were mostly underpowered. Here we report a meta- A nalysis for intelligence of 78,308 individuals. We identify 336 associated SNPs (METAL P < 5 × 10-8) in 18 genomic loci, of which 15 are new. Around half of the SNPs are located inside a gene, implicating 22 genes, of which 11 are new findings. Gene-based analyses identified an additional 30 genes (MAGMA P < 2.73 × 10-6), of which all but one had not been implicated previously. We show that the identified genes are predominantly expressed in brain tissue, and pathway analysis indicates the involvement of genes regulating cell development (MAGMA competitive P = 3.5 × 10-6). Despite the well-known difference in twin-based heritability for intelligence in childhood (0.45) and adulthood (0.80), we show substantial genetic correlation (rg = 0.89, LD score regression P = 5.4 × 10-29). These findings provide new insight into the genetic architecture of intelligence.

    AB - Intelligence is associated with important economic and health-related life outcomes. Despite intelligence having substantial heritability (0.54) and a confirmed polygenic nature, initial genetic studies were mostly underpowered. Here we report a meta- A nalysis for intelligence of 78,308 individuals. We identify 336 associated SNPs (METAL P < 5 × 10-8) in 18 genomic loci, of which 15 are new. Around half of the SNPs are located inside a gene, implicating 22 genes, of which 11 are new findings. Gene-based analyses identified an additional 30 genes (MAGMA P < 2.73 × 10-6), of which all but one had not been implicated previously. We show that the identified genes are predominantly expressed in brain tissue, and pathway analysis indicates the involvement of genes regulating cell development (MAGMA competitive P = 3.5 × 10-6). Despite the well-known difference in twin-based heritability for intelligence in childhood (0.45) and adulthood (0.80), we show substantial genetic correlation (rg = 0.89, LD score regression P = 5.4 × 10-29). These findings provide new insight into the genetic architecture of intelligence.

    UR - http://www.scopus.com/inward/record.url?scp=85020899420&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=85020899420&partnerID=8YFLogxK

    U2 - 10.1038/ng.3869

    DO - 10.1038/ng.3869

    M3 - Article

    VL - 49

    SP - 1107

    EP - 1112

    JO - Nature Genetics

    JF - Nature Genetics

    SN - 1061-4036

    IS - 7

    ER -