Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Social Science Genetic Association Consortium, 23and Me Research Team, eQTLgen Consortium, International Cannabis Consortium

    Research output: Contribution to journalArticle

    Abstract

    Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is genetically correlated (∣r̂ g∣ ~ 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.

    Original languageEnglish (US)
    Pages (from-to)245-257
    Number of pages13
    JournalNature Genetics
    Volume51
    Issue number2
    DOIs
    StatePublished - Feb 1 2019

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    Genetic Loci
    Genome-Wide Association Study
    Single Nucleotide Polymorphism
    Computational Biology
    Synaptic Transmission
    Genes
    Smoking
    Brain

    ASJC Scopus subject areas

    • Genetics

    Cite this

    Social Science Genetic Association Consortium, 23and Me Research Team, eQTLgen Consortium, & International Cannabis Consortium (2019). Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Nature Genetics, 51(2), 245-257. https://doi.org/10.1038/s41588-018-0309-3

    Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. / Social Science Genetic Association Consortium; 23and Me Research Team; eQTLgen Consortium; International Cannabis Consortium.

    In: Nature Genetics, Vol. 51, No. 2, 01.02.2019, p. 245-257.

    Research output: Contribution to journalArticle

    Social Science Genetic Association Consortium, 23and Me Research Team, eQTLgen Consortium & International Cannabis Consortium 2019, 'Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences', Nature Genetics, vol. 51, no. 2, pp. 245-257. https://doi.org/10.1038/s41588-018-0309-3
    Social Science Genetic Association Consortium, 23and Me Research Team, eQTLgen Consortium, International Cannabis Consortium. Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Nature Genetics. 2019 Feb 1;51(2):245-257. https://doi.org/10.1038/s41588-018-0309-3
    Social Science Genetic Association Consortium ; 23and Me Research Team ; eQTLgen Consortium ; International Cannabis Consortium. / Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. In: Nature Genetics. 2019 ; Vol. 51, No. 2. pp. 245-257.
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    abstract = "Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is genetically correlated (∣r̂ g∣ ~ 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.",
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