Genome-wide analysis identifies 12 loci influencing human reproductive behavior

Nicola Barban, Rick Jansen, Ronald De Vlaming, Ahmad Vaez, Jornt J. Mandemakers, Felix C. Tropf, Xia Shen, James F. Wilson, Daniel I. Chasman, Ilja M. Nolte, Vinicius Tragante, Sander W. Van Der Laan, John R.B. Perry, Augustine Kong, Tarunveer S. Ahluwalia, Eva Albrecht, Laura Yerges-Armstrong, Gil Atzmon, Kirsi Auro, Kristin Ayers & 233 others Andrew Bakshi, Danny Ben-Avraham, Klaus Berger, Aviv Bergman, Lars Bertram, Lawrence F. Bielak, Gyda Bjornsdottir, Marc Jan Bonder, Linda Broer, Minh Bui, Caterina Barbieri, Alana Cavadino, Jorge E. Chavarro, Constance Turman, Maria Pina Concas, Heather J. Cordell, Gail Davies, Peter Eibich, Nicholas Eriksson, Tõnu Esko, Joel Eriksson, Fahimeh Falahi, Janine F. Felix, Mark Alan Fontana, Lude Franke, Ilaria Gandin, Audrey J. Gaskins, Christian Gieger, Erica P. Gunderson, Xiuqing Guo, Caroline Hayward, Chunyan He, Edith Hofer, Hongyan Huang, Peter K. Joshi, Stavroula Kanoni, Robert Karlsson, Stefan Kiechl, Annette Kifley, Alexander Kluttig, Peter Kraft, Vasiliki Lagou, Cecile Lecoeur, Jari Lahti, Ruifang Li-Gao, Penelope A. Lind, Tian Liu, Enes Makalic, Crysovalanto Mamasoula, Lindsay Matteson, Hamdi Mbarek, Patrick F. McArdle, George McMahon, S. Fleur W. Meddens, Evelin Mihailov, Mike Miller, Stacey A. Missmer, Claire Monnereau, Peter J. Van Der Most, Ronny Myhre, Mike A. Nalls, Teresa Nutile, Ioanna Panagiota Kalafati, Eleonora Porcu, Inga Prokopenko, Kumar B. Rajan, Janet Rich-Edwards, Cornelius A. Rietveld, Antonietta Robino, Lynda M. Rose, Rico Rueedi, Kathleen A. Ryan, Yasaman Saba, Daniel Schmidt, Jennifer A. Smith, Lisette Stolk, Elizabeth Streeten, Anke Tönjes, Gudmar Thorleifsson, Sheila Ulivi, Juho Wedenoja, Juergen Wellmann, Peter Willeit, Jie Yao, Loic Yengo, Jing Hua Zhao, Wei Zhao, Daria V. Zhernakova, Najaf Amin, Howard Andrews, Beverley Balkau, Nir Barzilai, Sven Bergmann, Ginevra Biino, Hans Bisgaard, Klaus Bønnelykke, Dorret I. Boomsma, Julie E. Buring, Harry Campbell, Stefania Cappellani, Marina Ciullo, Simon R. Cox, Francesco Cucca, Daniela Toniolo, George Davey-Smith, Ian J. Deary, George Dedoussis, Panos Deloukas, Cornelia M. Van Duijn, Eco J.C. De Geus, Johan G. Eriksson, Denis A. Evans, Jessica D. Faul, Cinzia Felicita Sala, Philippe Froguel, Paolo Gasparini, Giorgia Girotto, Hans Jörgen Grabe, Karin Halina Greiser, Patrick J.F. Groenen, Hugoline G. De Haan, Johannes Haerting, Tamara B. Harris, Andrew C. Heath, Kauko Heikkilä, Albert Hofman, Georg Homuth, Elizabeth G. Holliday, John Hopper, Elina Hyppönen, Bo Jacobsson, Vincent W.V. Jaddoe, Magnus Johannesson, Astanand Jugessur, Mika Kähönen, Eero Kajantie, Sharon L.R. Kardia, Bernard Keavney, Ivana Kolcic, Päivikki Koponen, Peter Kovacs, Florian Kronenberg, Zoltan Kutalik, Martina La Bianca, Genevieve Lachance, William G. Iacono, Sandra Lai, Terho Lehtimäki, David C. Liewald, Cecilia M. Lindgren, Yongmei Liu, Robert Luben, Michael Lucht, Riitta Luoto, Per Magnus, Patrikke Magnusson, Nicholas G. Martin, Matt McGue, Ruth McQuillan, Sarah E. Medland, Christa Meisinger, Dan Mellström, Andres Metspalu, Michela Traglia, Lili Milani, Paul Mitchell, Grant W. Montgomery, Dennis Mook-Kanamori, Renée De Mutsert, Ellen A. Nohr, Claes Ohlsson, Jørn Olsen, Ken K. Ong, Lavinia Paternoster, Alison Pattie, Brenda W.J.H. Penninx, Markus Perola, Patricia A. Peyser, Mario Pirastu, Ozren Polasek, Chris Power, Jaakko Kaprio, Leslie J. Raffel, Katri Räikkönen, Olli Raitakari, Paul M. Ridker, Susan M. Ring, Kathryn Roll, Igor Rudan, Daniela Ruggiero, Dan Rujescu, Veikko Salomaa, David Schlessinger, Helena Schmidt, Reinhold Schmidt, Nicole Schupf, Johannes Smit, Rossella Sorice, Tim D. Spector, John M. Starr, Doris Stöckl, Konstantin Strauch, Michael Stumvoll, Morris A. Swertz, Unnur Thorsteinsdottir, A. Roy Thurik, Nicholas J. Timpson, Joyce Y. Tung, André G. Uitterlinden, Simona Vaccargiu, Jorma Viikari, Veronique Vitart, Henry Völzke, Peter Vollenweider, Dragana Vuckovic, Johannes Waage, Gert G. Wagner, Jie Jin Wang, Nicholas J. Wareham, David R. Weir, Gonneke Willemsen, Johann Willeit, Alan F. Wright, Krina T. Zondervan, Kari Stefansson, Robert F. Krueger, James J. Lee, Daniel J. Benjamin, David Cesarini, Philipp D. Koellinger, Marcel Den Hoed, Harold Snieder, Melinda C. Mills

    Research output: Contribution to journalArticle

    Abstract

    The genetic architecture of human reproductive behavior - age at first birth (AFB) and number of children ever born (NEB) - has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.

    Original languageEnglish (US)
    Pages (from-to)1462-1472
    Number of pages11
    JournalNature Genetics
    Volume48
    Issue number12
    DOIs
    StatePublished - Dec 1 2016

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    Reproductive Behavior
    Birth Order
    Genome
    Genome-Wide Association Study
    Infertility
    Genetic Loci
    Medical Genetics
    Human Development
    Genes
    Single Nucleotide Polymorphism
    Reproduction
    Gene Expression

    ASJC Scopus subject areas

    • Genetics

    Cite this

    Barban, N., Jansen, R., De Vlaming, R., Vaez, A., Mandemakers, J. J., Tropf, F. C., ... Mills, M. C. (2016). Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nature Genetics, 48(12), 1462-1472. https://doi.org/10.1038/ng.3698

    Genome-wide analysis identifies 12 loci influencing human reproductive behavior. / Barban, Nicola; Jansen, Rick; De Vlaming, Ronald; Vaez, Ahmad; Mandemakers, Jornt J.; Tropf, Felix C.; Shen, Xia; Wilson, James F.; Chasman, Daniel I.; Nolte, Ilja M.; Tragante, Vinicius; Van Der Laan, Sander W.; Perry, John R.B.; Kong, Augustine; Ahluwalia, Tarunveer S.; Albrecht, Eva; Yerges-Armstrong, Laura; Atzmon, Gil; Auro, Kirsi; Ayers, Kristin; Bakshi, Andrew; Ben-Avraham, Danny; Berger, Klaus; Bergman, Aviv; Bertram, Lars; Bielak, Lawrence F.; Bjornsdottir, Gyda; Bonder, Marc Jan; Broer, Linda; Bui, Minh; Barbieri, Caterina; Cavadino, Alana; Chavarro, Jorge E.; Turman, Constance; Concas, Maria Pina; Cordell, Heather J.; Davies, Gail; Eibich, Peter; Eriksson, Nicholas; Esko, Tõnu; Eriksson, Joel; Falahi, Fahimeh; Felix, Janine F.; Fontana, Mark Alan; Franke, Lude; Gandin, Ilaria; Gaskins, Audrey J.; Gieger, Christian; Gunderson, Erica P.; Guo, Xiuqing; Hayward, Caroline; He, Chunyan; Hofer, Edith; Huang, Hongyan; Joshi, Peter K.; Kanoni, Stavroula; Karlsson, Robert; Kiechl, Stefan; Kifley, Annette; Kluttig, Alexander; Kraft, Peter; Lagou, Vasiliki; Lecoeur, Cecile; Lahti, Jari; Li-Gao, Ruifang; Lind, Penelope A.; Liu, Tian; Makalic, Enes; Mamasoula, Crysovalanto; Matteson, Lindsay; Mbarek, Hamdi; McArdle, Patrick F.; McMahon, George; Meddens, S. Fleur W.; Mihailov, Evelin; Miller, Mike; Missmer, Stacey A.; Monnereau, Claire; Van Der Most, Peter J.; Myhre, Ronny; Nalls, Mike A.; Nutile, Teresa; Kalafati, Ioanna Panagiota; Porcu, Eleonora; Prokopenko, Inga; Rajan, Kumar B.; Rich-Edwards, Janet; Rietveld, Cornelius A.; Robino, Antonietta; Rose, Lynda M.; Rueedi, Rico; Ryan, Kathleen A.; Saba, Yasaman; Schmidt, Daniel; Smith, Jennifer A.; Stolk, Lisette; Streeten, Elizabeth; Tönjes, Anke; Thorleifsson, Gudmar; Ulivi, Sheila; Wedenoja, Juho; Wellmann, Juergen; Willeit, Peter; Yao, Jie; Yengo, Loic; Zhao, Jing Hua; Zhao, Wei; Zhernakova, Daria V.; Amin, Najaf; Andrews, Howard; Balkau, Beverley; Barzilai, Nir; Bergmann, Sven; Biino, Ginevra; Bisgaard, Hans; Bønnelykke, Klaus; Boomsma, Dorret I.; Buring, Julie E.; Campbell, Harry; Cappellani, Stefania; Ciullo, Marina; Cox, Simon R.; Cucca, Francesco; Toniolo, Daniela; Davey-Smith, George; Deary, Ian J.; Dedoussis, George; Deloukas, Panos; Van Duijn, Cornelia M.; De Geus, Eco J.C.; Eriksson, Johan G.; Evans, Denis A.; Faul, Jessica D.; Sala, Cinzia Felicita; Froguel, Philippe; Gasparini, Paolo; Girotto, Giorgia; Grabe, Hans Jörgen; Greiser, Karin Halina; Groenen, Patrick J.F.; De Haan, Hugoline G.; Haerting, Johannes; Harris, Tamara B.; Heath, Andrew C.; Heikkilä, Kauko; Hofman, Albert; Homuth, Georg; Holliday, Elizabeth G.; Hopper, John; Hyppönen, Elina; Jacobsson, Bo; Jaddoe, Vincent W.V.; Johannesson, Magnus; Jugessur, Astanand; Kähönen, Mika; Kajantie, Eero; Kardia, Sharon L.R.; Keavney, Bernard; Kolcic, Ivana; Koponen, Päivikki; Kovacs, Peter; Kronenberg, Florian; Kutalik, Zoltan; La Bianca, Martina; Lachance, Genevieve; Iacono, William G.; Lai, Sandra; Lehtimäki, Terho; Liewald, David C.; Lindgren, Cecilia M.; Liu, Yongmei; Luben, Robert; Lucht, Michael; Luoto, Riitta; Magnus, Per; Magnusson, Patrikke; Martin, Nicholas G.; McGue, Matt; McQuillan, Ruth; Medland, Sarah E.; Meisinger, Christa; Mellström, Dan; Metspalu, Andres; Traglia, Michela; Milani, Lili; Mitchell, Paul; Montgomery, Grant W.; Mook-Kanamori, Dennis; De Mutsert, Renée; Nohr, Ellen A.; Ohlsson, Claes; Olsen, Jørn; Ong, Ken K.; Paternoster, Lavinia; Pattie, Alison; Penninx, Brenda W.J.H.; Perola, Markus; Peyser, Patricia A.; Pirastu, Mario; Polasek, Ozren; Power, Chris; Kaprio, Jaakko; Raffel, Leslie J.; Räikkönen, Katri; Raitakari, Olli; Ridker, Paul M.; Ring, Susan M.; Roll, Kathryn; Rudan, Igor; Ruggiero, Daniela; Rujescu, Dan; Salomaa, Veikko; Schlessinger, David; Schmidt, Helena; Schmidt, Reinhold; Schupf, Nicole; Smit, Johannes; Sorice, Rossella; Spector, Tim D.; Starr, John M.; Stöckl, Doris; Strauch, Konstantin; Stumvoll, Michael; Swertz, Morris A.; Thorsteinsdottir, Unnur; Roy Thurik, A.; Timpson, Nicholas J.; Tung, Joyce Y.; Uitterlinden, André G.; Vaccargiu, Simona; Viikari, Jorma; Vitart, Veronique; Völzke, Henry; Vollenweider, Peter; Vuckovic, Dragana; Waage, Johannes; Wagner, Gert G.; Wang, Jie Jin; Wareham, Nicholas J.; Weir, David R.; Willemsen, Gonneke; Willeit, Johann; Wright, Alan F.; Zondervan, Krina T.; Stefansson, Kari; Krueger, Robert F.; Lee, James J.; Benjamin, Daniel J.; Cesarini, David; Koellinger, Philipp D.; Den Hoed, Marcel; Snieder, Harold; Mills, Melinda C.

    In: Nature Genetics, Vol. 48, No. 12, 01.12.2016, p. 1462-1472.

    Research output: Contribution to journalArticle

    Barban, N, Jansen, R, De Vlaming, R, Vaez, A, Mandemakers, JJ, Tropf, FC, Shen, X, Wilson, JF, Chasman, DI, Nolte, IM, Tragante, V, Van Der Laan, SW, Perry, JRB, Kong, A, Ahluwalia, TS, Albrecht, E, Yerges-Armstrong, L, Atzmon, G, Auro, K, Ayers, K, Bakshi, A, Ben-Avraham, D, Berger, K, Bergman, A, Bertram, L, Bielak, LF, Bjornsdottir, G, Bonder, MJ, Broer, L, Bui, M, Barbieri, C, Cavadino, A, Chavarro, JE, Turman, C, Concas, MP, Cordell, HJ, Davies, G, Eibich, P, Eriksson, N, Esko, T, Eriksson, J, Falahi, F, Felix, JF, Fontana, MA, Franke, L, Gandin, I, Gaskins, AJ, Gieger, C, Gunderson, EP, Guo, X, Hayward, C, He, C, Hofer, E, Huang, H, Joshi, PK, Kanoni, S, Karlsson, R, Kiechl, S, Kifley, A, Kluttig, A, Kraft, P, Lagou, V, Lecoeur, C, Lahti, J, Li-Gao, R, Lind, PA, Liu, T, Makalic, E, Mamasoula, C, Matteson, L, Mbarek, H, McArdle, PF, McMahon, G, Meddens, SFW, Mihailov, E, Miller, M, Missmer, SA, Monnereau, C, Van Der Most, PJ, Myhre, R, Nalls, MA, Nutile, T, Kalafati, IP, Porcu, E, Prokopenko, I, Rajan, KB, Rich-Edwards, J, Rietveld, CA, Robino, A, Rose, LM, Rueedi, R, Ryan, KA, Saba, Y, Schmidt, D, Smith, JA, Stolk, L, Streeten, E, Tönjes, A, Thorleifsson, G, Ulivi, S, Wedenoja, J, Wellmann, J, Willeit, P, Yao, J, Yengo, L, Zhao, JH, Zhao, W, Zhernakova, DV, Amin, N, Andrews, H, Balkau, B, Barzilai, N, Bergmann, S, Biino, G, Bisgaard, H, Bønnelykke, K, Boomsma, DI, Buring, JE, Campbell, H, Cappellani, S, Ciullo, M, Cox, SR, Cucca, F, Toniolo, D, Davey-Smith, G, Deary, IJ, Dedoussis, G, Deloukas, P, Van Duijn, CM, De Geus, EJC, Eriksson, JG, Evans, DA, Faul, JD, Sala, CF, Froguel, P, Gasparini, P, Girotto, G, Grabe, HJ, Greiser, KH, Groenen, PJF, De Haan, HG, Haerting, J, Harris, TB, Heath, AC, Heikkilä, K, Hofman, A, Homuth, G, Holliday, EG, Hopper, J, Hyppönen, E, Jacobsson, B, Jaddoe, VWV, Johannesson, M, Jugessur, A, Kähönen, M, Kajantie, E, Kardia, SLR, Keavney, B, Kolcic, I, Koponen, P, Kovacs, P, Kronenberg, F, Kutalik, Z, La Bianca, M, Lachance, G, Iacono, WG, Lai, S, Lehtimäki, T, Liewald, DC, Lindgren, CM, Liu, Y, Luben, R, Lucht, M, Luoto, R, Magnus, P, Magnusson, P, Martin, NG, McGue, M, McQuillan, R, Medland, SE, Meisinger, C, Mellström, D, Metspalu, A, Traglia, M, Milani, L, Mitchell, P, Montgomery, GW, Mook-Kanamori, D, De Mutsert, R, Nohr, EA, Ohlsson, C, Olsen, J, Ong, KK, Paternoster, L, Pattie, A, Penninx, BWJH, Perola, M, Peyser, PA, Pirastu, M, Polasek, O, Power, C, Kaprio, J, Raffel, LJ, Räikkönen, K, Raitakari, O, Ridker, PM, Ring, SM, Roll, K, Rudan, I, Ruggiero, D, Rujescu, D, Salomaa, V, Schlessinger, D, Schmidt, H, Schmidt, R, Schupf, N, Smit, J, Sorice, R, Spector, TD, Starr, JM, Stöckl, D, Strauch, K, Stumvoll, M, Swertz, MA, Thorsteinsdottir, U, Roy Thurik, A, Timpson, NJ, Tung, JY, Uitterlinden, AG, Vaccargiu, S, Viikari, J, Vitart, V, Völzke, H, Vollenweider, P, Vuckovic, D, Waage, J, Wagner, GG, Wang, JJ, Wareham, NJ, Weir, DR, Willemsen, G, Willeit, J, Wright, AF, Zondervan, KT, Stefansson, K, Krueger, RF, Lee, JJ, Benjamin, DJ, Cesarini, D, Koellinger, PD, Den Hoed, M, Snieder, H & Mills, MC 2016, 'Genome-wide analysis identifies 12 loci influencing human reproductive behavior', Nature Genetics, vol. 48, no. 12, pp. 1462-1472. https://doi.org/10.1038/ng.3698
    Barban N, Jansen R, De Vlaming R, Vaez A, Mandemakers JJ, Tropf FC et al. Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nature Genetics. 2016 Dec 1;48(12):1462-1472. https://doi.org/10.1038/ng.3698
    Barban, Nicola ; Jansen, Rick ; De Vlaming, Ronald ; Vaez, Ahmad ; Mandemakers, Jornt J. ; Tropf, Felix C. ; Shen, Xia ; Wilson, James F. ; Chasman, Daniel I. ; Nolte, Ilja M. ; Tragante, Vinicius ; Van Der Laan, Sander W. ; Perry, John R.B. ; Kong, Augustine ; Ahluwalia, Tarunveer S. ; Albrecht, Eva ; Yerges-Armstrong, Laura ; Atzmon, Gil ; Auro, Kirsi ; Ayers, Kristin ; Bakshi, Andrew ; Ben-Avraham, Danny ; Berger, Klaus ; Bergman, Aviv ; Bertram, Lars ; Bielak, Lawrence F. ; Bjornsdottir, Gyda ; Bonder, Marc Jan ; Broer, Linda ; Bui, Minh ; Barbieri, Caterina ; Cavadino, Alana ; Chavarro, Jorge E. ; Turman, Constance ; Concas, Maria Pina ; Cordell, Heather J. ; Davies, Gail ; Eibich, Peter ; Eriksson, Nicholas ; Esko, Tõnu ; Eriksson, Joel ; Falahi, Fahimeh ; Felix, Janine F. ; Fontana, Mark Alan ; Franke, Lude ; Gandin, Ilaria ; Gaskins, Audrey J. ; Gieger, Christian ; Gunderson, Erica P. ; Guo, Xiuqing ; Hayward, Caroline ; He, Chunyan ; Hofer, Edith ; Huang, Hongyan ; Joshi, Peter K. ; Kanoni, Stavroula ; Karlsson, Robert ; Kiechl, Stefan ; Kifley, Annette ; Kluttig, Alexander ; Kraft, Peter ; Lagou, Vasiliki ; Lecoeur, Cecile ; Lahti, Jari ; Li-Gao, Ruifang ; Lind, Penelope A. ; Liu, Tian ; Makalic, Enes ; Mamasoula, Crysovalanto ; Matteson, Lindsay ; Mbarek, Hamdi ; McArdle, Patrick F. ; McMahon, George ; Meddens, S. Fleur W. ; Mihailov, Evelin ; Miller, Mike ; Missmer, Stacey A. ; Monnereau, Claire ; Van Der Most, Peter J. ; Myhre, Ronny ; Nalls, Mike A. ; Nutile, Teresa ; Kalafati, Ioanna Panagiota ; Porcu, Eleonora ; Prokopenko, Inga ; Rajan, Kumar B. ; Rich-Edwards, Janet ; Rietveld, Cornelius A. ; Robino, Antonietta ; Rose, Lynda M. ; Rueedi, Rico ; Ryan, Kathleen A. ; Saba, Yasaman ; Schmidt, Daniel ; Smith, Jennifer A. ; Stolk, Lisette ; Streeten, Elizabeth ; Tönjes, Anke ; Thorleifsson, Gudmar ; Ulivi, Sheila ; Wedenoja, Juho ; Wellmann, Juergen ; Willeit, Peter ; Yao, Jie ; Yengo, Loic ; Zhao, Jing Hua ; Zhao, Wei ; Zhernakova, Daria V. ; Amin, Najaf ; Andrews, Howard ; Balkau, Beverley ; Barzilai, Nir ; Bergmann, Sven ; Biino, Ginevra ; Bisgaard, Hans ; Bønnelykke, Klaus ; Boomsma, Dorret I. ; Buring, Julie E. ; Campbell, Harry ; Cappellani, Stefania ; Ciullo, Marina ; Cox, Simon R. ; Cucca, Francesco ; Toniolo, Daniela ; Davey-Smith, George ; Deary, Ian J. ; Dedoussis, George ; Deloukas, Panos ; Van Duijn, Cornelia M. ; De Geus, Eco J.C. ; Eriksson, Johan G. ; Evans, Denis A. ; Faul, Jessica D. ; Sala, Cinzia Felicita ; Froguel, Philippe ; Gasparini, Paolo ; Girotto, Giorgia ; Grabe, Hans Jörgen ; Greiser, Karin Halina ; Groenen, Patrick J.F. ; De Haan, Hugoline G. ; Haerting, Johannes ; Harris, Tamara B. ; Heath, Andrew C. ; Heikkilä, Kauko ; Hofman, Albert ; Homuth, Georg ; Holliday, Elizabeth G. ; Hopper, John ; Hyppönen, Elina ; Jacobsson, Bo ; Jaddoe, Vincent W.V. ; Johannesson, Magnus ; Jugessur, Astanand ; Kähönen, Mika ; Kajantie, Eero ; Kardia, Sharon L.R. ; Keavney, Bernard ; Kolcic, Ivana ; Koponen, Päivikki ; Kovacs, Peter ; Kronenberg, Florian ; Kutalik, Zoltan ; La Bianca, Martina ; Lachance, Genevieve ; Iacono, William G. ; Lai, Sandra ; Lehtimäki, Terho ; Liewald, David C. ; Lindgren, Cecilia M. ; Liu, Yongmei ; Luben, Robert ; Lucht, Michael ; Luoto, Riitta ; Magnus, Per ; Magnusson, Patrikke ; Martin, Nicholas G. ; McGue, Matt ; McQuillan, Ruth ; Medland, Sarah E. ; Meisinger, Christa ; Mellström, Dan ; Metspalu, Andres ; Traglia, Michela ; Milani, Lili ; Mitchell, Paul ; Montgomery, Grant W. ; Mook-Kanamori, Dennis ; De Mutsert, Renée ; Nohr, Ellen A. ; Ohlsson, Claes ; Olsen, Jørn ; Ong, Ken K. ; Paternoster, Lavinia ; Pattie, Alison ; Penninx, Brenda W.J.H. ; Perola, Markus ; Peyser, Patricia A. ; Pirastu, Mario ; Polasek, Ozren ; Power, Chris ; Kaprio, Jaakko ; Raffel, Leslie J. ; Räikkönen, Katri ; Raitakari, Olli ; Ridker, Paul M. ; Ring, Susan M. ; Roll, Kathryn ; Rudan, Igor ; Ruggiero, Daniela ; Rujescu, Dan ; Salomaa, Veikko ; Schlessinger, David ; Schmidt, Helena ; Schmidt, Reinhold ; Schupf, Nicole ; Smit, Johannes ; Sorice, Rossella ; Spector, Tim D. ; Starr, John M. ; Stöckl, Doris ; Strauch, Konstantin ; Stumvoll, Michael ; Swertz, Morris A. ; Thorsteinsdottir, Unnur ; Roy Thurik, A. ; Timpson, Nicholas J. ; Tung, Joyce Y. ; Uitterlinden, André G. ; Vaccargiu, Simona ; Viikari, Jorma ; Vitart, Veronique ; Völzke, Henry ; Vollenweider, Peter ; Vuckovic, Dragana ; Waage, Johannes ; Wagner, Gert G. ; Wang, Jie Jin ; Wareham, Nicholas J. ; Weir, David R. ; Willemsen, Gonneke ; Willeit, Johann ; Wright, Alan F. ; Zondervan, Krina T. ; Stefansson, Kari ; Krueger, Robert F. ; Lee, James J. ; Benjamin, Daniel J. ; Cesarini, David ; Koellinger, Philipp D. ; Den Hoed, Marcel ; Snieder, Harold ; Mills, Melinda C. / Genome-wide analysis identifies 12 loci influencing human reproductive behavior. In: Nature Genetics. 2016 ; Vol. 48, No. 12. pp. 1462-1472.
    @article{f44550797e2b4d8bb6a1ef12e1b4e159,
    title = "Genome-wide analysis identifies 12 loci influencing human reproductive behavior",
    abstract = "The genetic architecture of human reproductive behavior - age at first birth (AFB) and number of children ever born (NEB) - has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.",
    author = "Nicola Barban and Rick Jansen and {De Vlaming}, Ronald and Ahmad Vaez and Mandemakers, {Jornt J.} and Tropf, {Felix C.} and Xia Shen and Wilson, {James F.} and Chasman, {Daniel I.} and Nolte, {Ilja M.} and Vinicius Tragante and {Van Der Laan}, {Sander W.} and Perry, {John R.B.} and Augustine Kong and Ahluwalia, {Tarunveer S.} and Eva Albrecht and Laura Yerges-Armstrong and Gil Atzmon and Kirsi Auro and Kristin Ayers and Andrew Bakshi and Danny Ben-Avraham and Klaus Berger and Aviv Bergman and Lars Bertram and Bielak, {Lawrence F.} and Gyda Bjornsdottir and Bonder, {Marc Jan} and Linda Broer and Minh Bui and Caterina Barbieri and Alana Cavadino and Chavarro, {Jorge E.} and Constance Turman and Concas, {Maria Pina} and Cordell, {Heather J.} and Gail Davies and Peter Eibich and Nicholas Eriksson and T{\~o}nu Esko and Joel Eriksson and Fahimeh Falahi and Felix, {Janine F.} and Fontana, {Mark Alan} and Lude Franke and Ilaria Gandin and Gaskins, {Audrey J.} and Christian Gieger and Gunderson, {Erica P.} and Xiuqing Guo and Caroline Hayward and Chunyan He and Edith Hofer and Hongyan Huang and Joshi, {Peter K.} and Stavroula Kanoni and Robert Karlsson and Stefan Kiechl and Annette Kifley and Alexander Kluttig and Peter Kraft and Vasiliki Lagou and Cecile Lecoeur and Jari Lahti and Ruifang Li-Gao and Lind, {Penelope A.} and Tian Liu and Enes Makalic and Crysovalanto Mamasoula and Lindsay Matteson and Hamdi Mbarek and McArdle, {Patrick F.} and George McMahon and Meddens, {S. Fleur W.} and Evelin Mihailov and Mike Miller and Missmer, {Stacey A.} and Claire Monnereau and {Van Der Most}, {Peter J.} and Ronny Myhre and Nalls, {Mike A.} and Teresa Nutile and Kalafati, {Ioanna Panagiota} and Eleonora Porcu and Inga Prokopenko and Rajan, {Kumar B.} and Janet Rich-Edwards and Rietveld, {Cornelius A.} and Antonietta Robino and Rose, {Lynda M.} and Rico Rueedi and Ryan, {Kathleen A.} and Yasaman Saba and Daniel Schmidt and Smith, {Jennifer A.} and Lisette Stolk and Elizabeth Streeten and Anke T{\"o}njes and Gudmar Thorleifsson and Sheila Ulivi and Juho Wedenoja and Juergen Wellmann and Peter Willeit and Jie Yao and Loic Yengo and Zhao, {Jing Hua} and Wei Zhao and Zhernakova, {Daria V.} and Najaf Amin and Howard Andrews and Beverley Balkau and Nir Barzilai and Sven Bergmann and Ginevra Biino and Hans Bisgaard and Klaus B{\o}nnelykke and Boomsma, {Dorret I.} and Buring, {Julie E.} and Harry Campbell and Stefania Cappellani and Marina Ciullo and Cox, {Simon R.} and Francesco Cucca and Daniela Toniolo and George Davey-Smith and Deary, {Ian J.} and George Dedoussis and Panos Deloukas and {Van Duijn}, {Cornelia M.} and {De Geus}, {Eco J.C.} and Eriksson, {Johan G.} and Evans, {Denis A.} and Faul, {Jessica D.} and Sala, {Cinzia Felicita} and Philippe Froguel and Paolo Gasparini and Giorgia Girotto and Grabe, {Hans J{\"o}rgen} and Greiser, {Karin Halina} and Groenen, {Patrick J.F.} and {De Haan}, {Hugoline G.} and Johannes Haerting and Harris, {Tamara B.} and Heath, {Andrew C.} and Kauko Heikkil{\"a} and Albert Hofman and Georg Homuth and Holliday, {Elizabeth G.} and John Hopper and Elina Hypp{\"o}nen and Bo Jacobsson and Jaddoe, {Vincent W.V.} and Magnus Johannesson and Astanand Jugessur and Mika K{\"a}h{\"o}nen and Eero Kajantie and Kardia, {Sharon L.R.} and Bernard Keavney and Ivana Kolcic and P{\"a}ivikki Koponen and Peter Kovacs and Florian Kronenberg and Zoltan Kutalik and {La Bianca}, Martina and Genevieve Lachance and Iacono, {William G.} and Sandra Lai and Terho Lehtim{\"a}ki and Liewald, {David C.} and Lindgren, {Cecilia M.} and Yongmei Liu and Robert Luben and Michael Lucht and Riitta Luoto and Per Magnus and Patrikke Magnusson and Martin, {Nicholas G.} and Matt McGue and Ruth McQuillan and Medland, {Sarah E.} and Christa Meisinger and Dan Mellstr{\"o}m and Andres Metspalu and Michela Traglia and Lili Milani and Paul Mitchell and Montgomery, {Grant W.} and Dennis Mook-Kanamori and {De Mutsert}, Ren{\'e}e and Nohr, {Ellen A.} and Claes Ohlsson and J{\o}rn Olsen and Ong, {Ken K.} and Lavinia Paternoster and Alison Pattie and Penninx, {Brenda W.J.H.} and Markus Perola and Peyser, {Patricia A.} and Mario Pirastu and Ozren Polasek and Chris Power and Jaakko Kaprio and Raffel, {Leslie J.} and Katri R{\"a}ikk{\"o}nen and Olli Raitakari and Ridker, {Paul M.} and Ring, {Susan M.} and Kathryn Roll and Igor Rudan and Daniela Ruggiero and Dan Rujescu and Veikko Salomaa and David Schlessinger and Helena Schmidt and Reinhold Schmidt and Nicole Schupf and Johannes Smit and Rossella Sorice and Spector, {Tim D.} and Starr, {John M.} and Doris St{\"o}ckl and Konstantin Strauch and Michael Stumvoll and Swertz, {Morris A.} and Unnur Thorsteinsdottir and {Roy Thurik}, A. and Timpson, {Nicholas J.} and Tung, {Joyce Y.} and Uitterlinden, {Andr{\'e} G.} and Simona Vaccargiu and Jorma Viikari and Veronique Vitart and Henry V{\"o}lzke and Peter Vollenweider and Dragana Vuckovic and Johannes Waage and Wagner, {Gert G.} and Wang, {Jie Jin} and Wareham, {Nicholas J.} and Weir, {David R.} and Gonneke Willemsen and Johann Willeit and Wright, {Alan F.} and Zondervan, {Krina T.} and Kari Stefansson and Krueger, {Robert F.} and Lee, {James J.} and Benjamin, {Daniel J.} and David Cesarini and Koellinger, {Philipp D.} and {Den Hoed}, Marcel and Harold Snieder and Mills, {Melinda C.}",
    year = "2016",
    month = "12",
    day = "1",
    doi = "10.1038/ng.3698",
    language = "English (US)",
    volume = "48",
    pages = "1462--1472",
    journal = "Nature Genetics",
    issn = "1061-4036",
    publisher = "Nature Publishing Group",
    number = "12",

    }

    TY - JOUR

    T1 - Genome-wide analysis identifies 12 loci influencing human reproductive behavior

    AU - Barban, Nicola

    AU - Jansen, Rick

    AU - De Vlaming, Ronald

    AU - Vaez, Ahmad

    AU - Mandemakers, Jornt J.

    AU - Tropf, Felix C.

    AU - Shen, Xia

    AU - Wilson, James F.

    AU - Chasman, Daniel I.

    AU - Nolte, Ilja M.

    AU - Tragante, Vinicius

    AU - Van Der Laan, Sander W.

    AU - Perry, John R.B.

    AU - Kong, Augustine

    AU - Ahluwalia, Tarunveer S.

    AU - Albrecht, Eva

    AU - Yerges-Armstrong, Laura

    AU - Atzmon, Gil

    AU - Auro, Kirsi

    AU - Ayers, Kristin

    AU - Bakshi, Andrew

    AU - Ben-Avraham, Danny

    AU - Berger, Klaus

    AU - Bergman, Aviv

    AU - Bertram, Lars

    AU - Bielak, Lawrence F.

    AU - Bjornsdottir, Gyda

    AU - Bonder, Marc Jan

    AU - Broer, Linda

    AU - Bui, Minh

    AU - Barbieri, Caterina

    AU - Cavadino, Alana

    AU - Chavarro, Jorge E.

    AU - Turman, Constance

    AU - Concas, Maria Pina

    AU - Cordell, Heather J.

    AU - Davies, Gail

    AU - Eibich, Peter

    AU - Eriksson, Nicholas

    AU - Esko, Tõnu

    AU - Eriksson, Joel

    AU - Falahi, Fahimeh

    AU - Felix, Janine F.

    AU - Fontana, Mark Alan

    AU - Franke, Lude

    AU - Gandin, Ilaria

    AU - Gaskins, Audrey J.

    AU - Gieger, Christian

    AU - Gunderson, Erica P.

    AU - Guo, Xiuqing

    AU - Hayward, Caroline

    AU - He, Chunyan

    AU - Hofer, Edith

    AU - Huang, Hongyan

    AU - Joshi, Peter K.

    AU - Kanoni, Stavroula

    AU - Karlsson, Robert

    AU - Kiechl, Stefan

    AU - Kifley, Annette

    AU - Kluttig, Alexander

    AU - Kraft, Peter

    AU - Lagou, Vasiliki

    AU - Lecoeur, Cecile

    AU - Lahti, Jari

    AU - Li-Gao, Ruifang

    AU - Lind, Penelope A.

    AU - Liu, Tian

    AU - Makalic, Enes

    AU - Mamasoula, Crysovalanto

    AU - Matteson, Lindsay

    AU - Mbarek, Hamdi

    AU - McArdle, Patrick F.

    AU - McMahon, George

    AU - Meddens, S. Fleur W.

    AU - Mihailov, Evelin

    AU - Miller, Mike

    AU - Missmer, Stacey A.

    AU - Monnereau, Claire

    AU - Van Der Most, Peter J.

    AU - Myhre, Ronny

    AU - Nalls, Mike A.

    AU - Nutile, Teresa

    AU - Kalafati, Ioanna Panagiota

    AU - Porcu, Eleonora

    AU - Prokopenko, Inga

    AU - Rajan, Kumar B.

    AU - Rich-Edwards, Janet

    AU - Rietveld, Cornelius A.

    AU - Robino, Antonietta

    AU - Rose, Lynda M.

    AU - Rueedi, Rico

    AU - Ryan, Kathleen A.

    AU - Saba, Yasaman

    AU - Schmidt, Daniel

    AU - Smith, Jennifer A.

    AU - Stolk, Lisette

    AU - Streeten, Elizabeth

    AU - Tönjes, Anke

    AU - Thorleifsson, Gudmar

    AU - Ulivi, Sheila

    AU - Wedenoja, Juho

    AU - Wellmann, Juergen

    AU - Willeit, Peter

    AU - Yao, Jie

    AU - Yengo, Loic

    AU - Zhao, Jing Hua

    AU - Zhao, Wei

    AU - Zhernakova, Daria V.

    AU - Amin, Najaf

    AU - Andrews, Howard

    AU - Balkau, Beverley

    AU - Barzilai, Nir

    AU - Bergmann, Sven

    AU - Biino, Ginevra

    AU - Bisgaard, Hans

    AU - Bønnelykke, Klaus

    AU - Boomsma, Dorret I.

    AU - Buring, Julie E.

    AU - Campbell, Harry

    AU - Cappellani, Stefania

    AU - Ciullo, Marina

    AU - Cox, Simon R.

    AU - Cucca, Francesco

    AU - Toniolo, Daniela

    AU - Davey-Smith, George

    AU - Deary, Ian J.

    AU - Dedoussis, George

    AU - Deloukas, Panos

    AU - Van Duijn, Cornelia M.

    AU - De Geus, Eco J.C.

    AU - Eriksson, Johan G.

    AU - Evans, Denis A.

    AU - Faul, Jessica D.

    AU - Sala, Cinzia Felicita

    AU - Froguel, Philippe

    AU - Gasparini, Paolo

    AU - Girotto, Giorgia

    AU - Grabe, Hans Jörgen

    AU - Greiser, Karin Halina

    AU - Groenen, Patrick J.F.

    AU - De Haan, Hugoline G.

    AU - Haerting, Johannes

    AU - Harris, Tamara B.

    AU - Heath, Andrew C.

    AU - Heikkilä, Kauko

    AU - Hofman, Albert

    AU - Homuth, Georg

    AU - Holliday, Elizabeth G.

    AU - Hopper, John

    AU - Hyppönen, Elina

    AU - Jacobsson, Bo

    AU - Jaddoe, Vincent W.V.

    AU - Johannesson, Magnus

    AU - Jugessur, Astanand

    AU - Kähönen, Mika

    AU - Kajantie, Eero

    AU - Kardia, Sharon L.R.

    AU - Keavney, Bernard

    AU - Kolcic, Ivana

    AU - Koponen, Päivikki

    AU - Kovacs, Peter

    AU - Kronenberg, Florian

    AU - Kutalik, Zoltan

    AU - La Bianca, Martina

    AU - Lachance, Genevieve

    AU - Iacono, William G.

    AU - Lai, Sandra

    AU - Lehtimäki, Terho

    AU - Liewald, David C.

    AU - Lindgren, Cecilia M.

    AU - Liu, Yongmei

    AU - Luben, Robert

    AU - Lucht, Michael

    AU - Luoto, Riitta

    AU - Magnus, Per

    AU - Magnusson, Patrikke

    AU - Martin, Nicholas G.

    AU - McGue, Matt

    AU - McQuillan, Ruth

    AU - Medland, Sarah E.

    AU - Meisinger, Christa

    AU - Mellström, Dan

    AU - Metspalu, Andres

    AU - Traglia, Michela

    AU - Milani, Lili

    AU - Mitchell, Paul

    AU - Montgomery, Grant W.

    AU - Mook-Kanamori, Dennis

    AU - De Mutsert, Renée

    AU - Nohr, Ellen A.

    AU - Ohlsson, Claes

    AU - Olsen, Jørn

    AU - Ong, Ken K.

    AU - Paternoster, Lavinia

    AU - Pattie, Alison

    AU - Penninx, Brenda W.J.H.

    AU - Perola, Markus

    AU - Peyser, Patricia A.

    AU - Pirastu, Mario

    AU - Polasek, Ozren

    AU - Power, Chris

    AU - Kaprio, Jaakko

    AU - Raffel, Leslie J.

    AU - Räikkönen, Katri

    AU - Raitakari, Olli

    AU - Ridker, Paul M.

    AU - Ring, Susan M.

    AU - Roll, Kathryn

    AU - Rudan, Igor

    AU - Ruggiero, Daniela

    AU - Rujescu, Dan

    AU - Salomaa, Veikko

    AU - Schlessinger, David

    AU - Schmidt, Helena

    AU - Schmidt, Reinhold

    AU - Schupf, Nicole

    AU - Smit, Johannes

    AU - Sorice, Rossella

    AU - Spector, Tim D.

    AU - Starr, John M.

    AU - Stöckl, Doris

    AU - Strauch, Konstantin

    AU - Stumvoll, Michael

    AU - Swertz, Morris A.

    AU - Thorsteinsdottir, Unnur

    AU - Roy Thurik, A.

    AU - Timpson, Nicholas J.

    AU - Tung, Joyce Y.

    AU - Uitterlinden, André G.

    AU - Vaccargiu, Simona

    AU - Viikari, Jorma

    AU - Vitart, Veronique

    AU - Völzke, Henry

    AU - Vollenweider, Peter

    AU - Vuckovic, Dragana

    AU - Waage, Johannes

    AU - Wagner, Gert G.

    AU - Wang, Jie Jin

    AU - Wareham, Nicholas J.

    AU - Weir, David R.

    AU - Willemsen, Gonneke

    AU - Willeit, Johann

    AU - Wright, Alan F.

    AU - Zondervan, Krina T.

    AU - Stefansson, Kari

    AU - Krueger, Robert F.

    AU - Lee, James J.

    AU - Benjamin, Daniel J.

    AU - Cesarini, David

    AU - Koellinger, Philipp D.

    AU - Den Hoed, Marcel

    AU - Snieder, Harold

    AU - Mills, Melinda C.

    PY - 2016/12/1

    Y1 - 2016/12/1

    N2 - The genetic architecture of human reproductive behavior - age at first birth (AFB) and number of children ever born (NEB) - has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.

    AB - The genetic architecture of human reproductive behavior - age at first birth (AFB) and number of children ever born (NEB) - has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.

    UR - http://www.scopus.com/inward/record.url?scp=85006437095&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=85006437095&partnerID=8YFLogxK

    U2 - 10.1038/ng.3698

    DO - 10.1038/ng.3698

    M3 - Article

    VL - 48

    SP - 1462

    EP - 1472

    JO - Nature Genetics

    JF - Nature Genetics

    SN - 1061-4036

    IS - 12

    ER -