Genome sequence of the human malaria parasite Plasmodium falciparum

Malcolm J. Gardner, Neil Hall, Eula Fung, Owen White, Matthew Berriman, Richard W. Hyman, Jane M. Carlton, Arnab Pain, Karen E. Nelson, Sharen Bowman, Ian T. Paulsen, Keith James, Jonathan A. Eisen, Kim Rutherford, Steven L. Salzberg, Alister Craig, Sue Kyes, Man Suen Chan, Vishvanath Nene, Shamira J. ShallomBernard Suh, Jeremy Peterson, Sam Angiuoli, Mihaela Pertea, Jonathan Allen, Jeremy Selengut, Daniel Haft, Michael W. Mather, Akhil B. Vaidya, David M A Martin, Alan H. Fairlamb, Martin J. Fraunholz, David S. Roos, Stuart A. Ralph, Geoffrey I. McFadden, Leda M. Cummings, G. Mani Subramanian, Chris Mungall, J. Craig Venter, Daniel J. Carucci, Stephen L. Hoffman, Chris Newbold, Ronald W. Davis, Claire M. Fraser, Bart Barrell

Research output: Contribution to journalArticle

Abstract

The parasite Plasmodium falciparum is responsible for hundreds of millions of cases of malaria, and kills more than one million African children annually. Here we report an analysis of the genome sequence of P. falciparum clone 3D7. The 23-megabase nuclear genome consists of 14 chromosomes, encodes about 5,300 genes, and is the most (A + T)-rich genome sequenced to date. Genes involved in antigenic variation are concentrated in the subtelomeric regions of the chromosomes. Compared to the genomes of free-living eukaryotic microbes, the genome of this intracellular parasite encodes fewer enzymes and transporters, but a large proportion of genes are devoted to immune evasion and host-parasite interactions. Many nuclear-encoded proteins are targeted to the apicoplast, an organelle involved in fatty-acid and isoprenoid metabolism. The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria.

Original languageEnglish (US)
Pages (from-to)498-511
Number of pages14
JournalNature
Volume419
Issue number6906
DOIs
StatePublished - Oct 3 2002

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Falciparum Malaria
Human Genome
Parasites
Genome
Plasmodium falciparum
Malaria
Apicoplasts
Genes
Immune Evasion
Chromosomes, Human, Pair 14
Antigenic Variation
Host-Parasite Interactions
Terpenes
Nuclear Proteins
Organelles
Sequence Analysis
Fatty Acids
Vaccines
Clone Cells
Chromosomes

ASJC Scopus subject areas

  • General

Cite this

Gardner, M. J., Hall, N., Fung, E., White, O., Berriman, M., Hyman, R. W., ... Barrell, B. (2002). Genome sequence of the human malaria parasite Plasmodium falciparum. Nature, 419(6906), 498-511. https://doi.org/10.1038/nature01097

Genome sequence of the human malaria parasite Plasmodium falciparum. / Gardner, Malcolm J.; Hall, Neil; Fung, Eula; White, Owen; Berriman, Matthew; Hyman, Richard W.; Carlton, Jane M.; Pain, Arnab; Nelson, Karen E.; Bowman, Sharen; Paulsen, Ian T.; James, Keith; Eisen, Jonathan A.; Rutherford, Kim; Salzberg, Steven L.; Craig, Alister; Kyes, Sue; Chan, Man Suen; Nene, Vishvanath; Shallom, Shamira J.; Suh, Bernard; Peterson, Jeremy; Angiuoli, Sam; Pertea, Mihaela; Allen, Jonathan; Selengut, Jeremy; Haft, Daniel; Mather, Michael W.; Vaidya, Akhil B.; Martin, David M A; Fairlamb, Alan H.; Fraunholz, Martin J.; Roos, David S.; Ralph, Stuart A.; McFadden, Geoffrey I.; Cummings, Leda M.; Subramanian, G. Mani; Mungall, Chris; Venter, J. Craig; Carucci, Daniel J.; Hoffman, Stephen L.; Newbold, Chris; Davis, Ronald W.; Fraser, Claire M.; Barrell, Bart.

In: Nature, Vol. 419, No. 6906, 03.10.2002, p. 498-511.

Research output: Contribution to journalArticle

Gardner, MJ, Hall, N, Fung, E, White, O, Berriman, M, Hyman, RW, Carlton, JM, Pain, A, Nelson, KE, Bowman, S, Paulsen, IT, James, K, Eisen, JA, Rutherford, K, Salzberg, SL, Craig, A, Kyes, S, Chan, MS, Nene, V, Shallom, SJ, Suh, B, Peterson, J, Angiuoli, S, Pertea, M, Allen, J, Selengut, J, Haft, D, Mather, MW, Vaidya, AB, Martin, DMA, Fairlamb, AH, Fraunholz, MJ, Roos, DS, Ralph, SA, McFadden, GI, Cummings, LM, Subramanian, GM, Mungall, C, Venter, JC, Carucci, DJ, Hoffman, SL, Newbold, C, Davis, RW, Fraser, CM & Barrell, B 2002, 'Genome sequence of the human malaria parasite Plasmodium falciparum', Nature, vol. 419, no. 6906, pp. 498-511. https://doi.org/10.1038/nature01097
Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW et al. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature. 2002 Oct 3;419(6906):498-511. https://doi.org/10.1038/nature01097
Gardner, Malcolm J. ; Hall, Neil ; Fung, Eula ; White, Owen ; Berriman, Matthew ; Hyman, Richard W. ; Carlton, Jane M. ; Pain, Arnab ; Nelson, Karen E. ; Bowman, Sharen ; Paulsen, Ian T. ; James, Keith ; Eisen, Jonathan A. ; Rutherford, Kim ; Salzberg, Steven L. ; Craig, Alister ; Kyes, Sue ; Chan, Man Suen ; Nene, Vishvanath ; Shallom, Shamira J. ; Suh, Bernard ; Peterson, Jeremy ; Angiuoli, Sam ; Pertea, Mihaela ; Allen, Jonathan ; Selengut, Jeremy ; Haft, Daniel ; Mather, Michael W. ; Vaidya, Akhil B. ; Martin, David M A ; Fairlamb, Alan H. ; Fraunholz, Martin J. ; Roos, David S. ; Ralph, Stuart A. ; McFadden, Geoffrey I. ; Cummings, Leda M. ; Subramanian, G. Mani ; Mungall, Chris ; Venter, J. Craig ; Carucci, Daniel J. ; Hoffman, Stephen L. ; Newbold, Chris ; Davis, Ronald W. ; Fraser, Claire M. ; Barrell, Bart. / Genome sequence of the human malaria parasite Plasmodium falciparum. In: Nature. 2002 ; Vol. 419, No. 6906. pp. 498-511.
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AU - Pain, Arnab

AU - Nelson, Karen E.

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AU - Paulsen, Ian T.

AU - James, Keith

AU - Eisen, Jonathan A.

AU - Rutherford, Kim

AU - Salzberg, Steven L.

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AU - Chan, Man Suen

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AU - Suh, Bernard

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AU - Subramanian, G. Mani

AU - Mungall, Chris

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AU - Carucci, Daniel J.

AU - Hoffman, Stephen L.

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