Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii

Jane M. Carlton, Samuel V. Angiuoli, Bernard B. Suh, Taco W. Kooij, Mihaela Pertea, Joana C. Silva, Maria D. Ermolaeva, Jonathan E. Allen, Jeremy D. Selengut, Hean L. Koo, Jeremy D. Peterson, Mihai Pop, Daniel S. Kosack, Martin F. Shumway, Shelby L. Bidwell, Shamira J. Shallom, Susan E. Van Aken, Steven B. Riedmuller, Tamara V. Feldblyum, Jennifer K. Cho & 24 others John Quackenbush, Martha Sedegah, Azadeh Shoaibi, Leda M. Cummings, Laurence Florens, John R. Yates, J. Dale Raine, Robert E. Sinden, Michael A. Harris, Deirdre A. Cunningham, Peter R. Preiser, Lawrence W. Bergman, Akhil B. Vaidya, Leo H. Van Lin, Chris J. Janse, Andrew P. Waters, Hamilton O. Smith, Owen R. White, Steven L. Salzberg, J. Craig Venter, Claire M. Fraser, Stephen L. Hoffman, Malcolm J. Gardner, Daniel J. Carucci

Research output: Contribution to journalArticle

Abstract

Species of malaria parasite that infect rodents have long been used as models for malaria disease research. Here we report the whole-genome shotgun sequence of one species, Plasmodium yoelii yoelii, and comparative studies with the genome of the human malaria parasite Plasmodium falciparum clone 3D7. A synteny map of 2,212 P. y. yoelii contiguous DNA sequences (contigs) aligned to 14 P. falciparum chromosomes reveals marked conservation of gene synteny within the body of each chromosome. Of about 5,300 P. falciparum genes, more than 3,300 P. y. yoelii orthologues of predominantly metabolic function were identified. Over 800 copies of a variant antigen gene located in subtelomeric regions were found. This is the first genome sequence of a model eukaryotic parasite, and it provides insight into the use of such systems in the modelling of Plasmodium biology and disease.

Original languageEnglish (US)
Pages (from-to)512-519
Number of pages8
JournalNature
Volume419
Issue number6906
DOIs
StatePublished - Oct 3 2002

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Plasmodium yoelii
Malaria
Synteny
Sequence Analysis
Rodentia
Parasites
Genome
Plasmodium falciparum
Chromosomes
Genes
Plasmodium
Falciparum Malaria
Firearms
Human Genome
Clone Cells
Antigens
Research

ASJC Scopus subject areas

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Carlton, J. M., Angiuoli, S. V., Suh, B. B., Kooij, T. W., Pertea, M., Silva, J. C., ... Carucci, D. J. (2002). Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. Nature, 419(6906), 512-519. https://doi.org/10.1038/nature01099

Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. / Carlton, Jane M.; Angiuoli, Samuel V.; Suh, Bernard B.; Kooij, Taco W.; Pertea, Mihaela; Silva, Joana C.; Ermolaeva, Maria D.; Allen, Jonathan E.; Selengut, Jeremy D.; Koo, Hean L.; Peterson, Jeremy D.; Pop, Mihai; Kosack, Daniel S.; Shumway, Martin F.; Bidwell, Shelby L.; Shallom, Shamira J.; Van Aken, Susan E.; Riedmuller, Steven B.; Feldblyum, Tamara V.; Cho, Jennifer K.; Quackenbush, John; Sedegah, Martha; Shoaibi, Azadeh; Cummings, Leda M.; Florens, Laurence; Yates, John R.; Raine, J. Dale; Sinden, Robert E.; Harris, Michael A.; Cunningham, Deirdre A.; Preiser, Peter R.; Bergman, Lawrence W.; Vaidya, Akhil B.; Van Lin, Leo H.; Janse, Chris J.; Waters, Andrew P.; Smith, Hamilton O.; White, Owen R.; Salzberg, Steven L.; Venter, J. Craig; Fraser, Claire M.; Hoffman, Stephen L.; Gardner, Malcolm J.; Carucci, Daniel J.

In: Nature, Vol. 419, No. 6906, 03.10.2002, p. 512-519.

Research output: Contribution to journalArticle

Carlton, JM, Angiuoli, SV, Suh, BB, Kooij, TW, Pertea, M, Silva, JC, Ermolaeva, MD, Allen, JE, Selengut, JD, Koo, HL, Peterson, JD, Pop, M, Kosack, DS, Shumway, MF, Bidwell, SL, Shallom, SJ, Van Aken, SE, Riedmuller, SB, Feldblyum, TV, Cho, JK, Quackenbush, J, Sedegah, M, Shoaibi, A, Cummings, LM, Florens, L, Yates, JR, Raine, JD, Sinden, RE, Harris, MA, Cunningham, DA, Preiser, PR, Bergman, LW, Vaidya, AB, Van Lin, LH, Janse, CJ, Waters, AP, Smith, HO, White, OR, Salzberg, SL, Venter, JC, Fraser, CM, Hoffman, SL, Gardner, MJ & Carucci, DJ 2002, 'Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii', Nature, vol. 419, no. 6906, pp. 512-519. https://doi.org/10.1038/nature01099
Carlton, Jane M. ; Angiuoli, Samuel V. ; Suh, Bernard B. ; Kooij, Taco W. ; Pertea, Mihaela ; Silva, Joana C. ; Ermolaeva, Maria D. ; Allen, Jonathan E. ; Selengut, Jeremy D. ; Koo, Hean L. ; Peterson, Jeremy D. ; Pop, Mihai ; Kosack, Daniel S. ; Shumway, Martin F. ; Bidwell, Shelby L. ; Shallom, Shamira J. ; Van Aken, Susan E. ; Riedmuller, Steven B. ; Feldblyum, Tamara V. ; Cho, Jennifer K. ; Quackenbush, John ; Sedegah, Martha ; Shoaibi, Azadeh ; Cummings, Leda M. ; Florens, Laurence ; Yates, John R. ; Raine, J. Dale ; Sinden, Robert E. ; Harris, Michael A. ; Cunningham, Deirdre A. ; Preiser, Peter R. ; Bergman, Lawrence W. ; Vaidya, Akhil B. ; Van Lin, Leo H. ; Janse, Chris J. ; Waters, Andrew P. ; Smith, Hamilton O. ; White, Owen R. ; Salzberg, Steven L. ; Venter, J. Craig ; Fraser, Claire M. ; Hoffman, Stephen L. ; Gardner, Malcolm J. ; Carucci, Daniel J. / Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. In: Nature. 2002 ; Vol. 419, No. 6906. pp. 512-519.
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AU - Angiuoli, Samuel V.

AU - Suh, Bernard B.

AU - Kooij, Taco W.

AU - Pertea, Mihaela

AU - Silva, Joana C.

AU - Ermolaeva, Maria D.

AU - Allen, Jonathan E.

AU - Selengut, Jeremy D.

AU - Koo, Hean L.

AU - Peterson, Jeremy D.

AU - Pop, Mihai

AU - Kosack, Daniel S.

AU - Shumway, Martin F.

AU - Bidwell, Shelby L.

AU - Shallom, Shamira J.

AU - Van Aken, Susan E.

AU - Riedmuller, Steven B.

AU - Feldblyum, Tamara V.

AU - Cho, Jennifer K.

AU - Quackenbush, John

AU - Sedegah, Martha

AU - Shoaibi, Azadeh

AU - Cummings, Leda M.

AU - Florens, Laurence

AU - Yates, John R.

AU - Raine, J. Dale

AU - Sinden, Robert E.

AU - Harris, Michael A.

AU - Cunningham, Deirdre A.

AU - Preiser, Peter R.

AU - Bergman, Lawrence W.

AU - Vaidya, Akhil B.

AU - Van Lin, Leo H.

AU - Janse, Chris J.

AU - Waters, Andrew P.

AU - Smith, Hamilton O.

AU - White, Owen R.

AU - Salzberg, Steven L.

AU - Venter, J. Craig

AU - Fraser, Claire M.

AU - Hoffman, Stephen L.

AU - Gardner, Malcolm J.

AU - Carucci, Daniel J.

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