Genetics of global gene expression

Matthew Rockman, Leonid Kruglyak

Research output: Contribution to journalArticle

Abstract

A new field of genetic analysis of global gene expression has emerged in recent years, driven by the realization that traditional techniques of linkage and association analysis can be applied to thousands of transcript levels measured by microarrays. Genetic dissection of transcript abundance has shed light on the architecture of quantitative traits, provided a new approach for connecting DNA sequence variation with phenotypic variation, and improved our understanding of transcriptional regulation and regulatory variation.

Original languageEnglish (US)
Pages (from-to)862-872
Number of pages11
JournalNature Reviews Genetics
Volume7
Issue number11
DOIs
StatePublished - Nov 2006

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quantitative traits
phenotypic variation
linkage (genetics)
genetic techniques and protocols
Dissection
Gene Expression
nucleotide sequences
gene expression
methodology
sequence diversity

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)

Cite this

Genetics of global gene expression. / Rockman, Matthew; Kruglyak, Leonid.

In: Nature Reviews Genetics, Vol. 7, No. 11, 11.2006, p. 862-872.

Research output: Contribution to journalArticle

Rockman, Matthew ; Kruglyak, Leonid. / Genetics of global gene expression. In: Nature Reviews Genetics. 2006 ; Vol. 7, No. 11. pp. 862-872.
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