Genetics of chronic pain: Crucial concepts in genetics and research tools to understand the molecular biology of pain and analgesia

Bradley E. Aouizerat, Christine A. Miaskowski

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Note 48 Concepts and tools in genetics and genomics 48 Introduction 48 Genes and chromosomes 49 Gene expression and protein synthesis - regulation of gene expression 49 DNA and human diversity 51 Complex, multifactorial disorders 53 Approaches used to conduct genetic studies 53 Expression analyses: RNA-based studies 57 Proteome analyses: protein-based studies 59 The new frontier: systems biology 60 Research-related issues unique to the study of pain alleles 60 Genetics and pain sensitivity 60 The complexities of determining genetic risk factors for chronic pain 60 Pharmacogenetics and analgesic drugs 61 Molecular biologic tools in the elucidation of pain mechanisms and drug discovery 63 References 63 The genetics of pain is a complex trait, due to a combination of genetic and environmental factors.

Original languageEnglish (US)
Title of host publicationClinical Pain Management
Subtitle of host publicationChronic Pain, Second Edition
PublisherCRC Press
Pages48-64
Number of pages17
ISBN (Electronic)9781444109818
ISBN (Print)9780340940082
StatePublished - Jan 1 2008

ASJC Scopus subject areas

  • Health Professions(all)
  • Medicine(all)

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    Aouizerat, B. E., & Miaskowski, C. A. (2008). Genetics of chronic pain: Crucial concepts in genetics and research tools to understand the molecular biology of pain and analgesia. In Clinical Pain Management: Chronic Pain, Second Edition (pp. 48-64). CRC Press.