Genetically Dissecting Cortical Neurons Involved in Epilepsy in Angelman Syndrome

Emanuela Santini, Eric Klann

Research output: Contribution to journalShort survey

Abstract

Epilepsy in Angelman Syndrome is thought to originate from an imbalance between local excitatory-inhibitory circuits that results in a generalized hyperexcitability. In this issue of Neuron, Judson et al. (2016) demonstrate that selective maternal deletion of Ube3a in cortical GABAergic neurons causes circuit hyperexcitability, increased seizure severity, and EEG abnormalities.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalNeuron
Volume90
Issue number1
DOIs
StatePublished - Apr 6 2016

ASJC Scopus subject areas

  • Neuroscience(all)

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