Genetic contribution to brachial artery flow-mediated dilation

The Northern Manhattan Family Study

Keiko Suzuki, Suh Hang Hank Juo, Tanja Rundek, Bernadette Boden-Albala, Norbelina Disla, Rui Liu, Naeun Park, Marco R. Di Tullio, Ralph L. Sacco, Shunichi Homma

Research output: Contribution to journalArticle

Abstract

Background: Brachial artery flow-mediated dilation (FMD) is a non-invasive measure of endothelial function. Endothelial dysfunction has been associated with traditional vascular risk factors and increased risk of cardiovascular disease. The importance of genetic contribution to FMD and baseline brachial artery diameter has not been shown in Hispanic populations. The purpose of this study was to estimate the heritability of FMD. Methods: Flow mediated dilation and brachial artery diameter were measured in a subset of Caribbean Hispanic families from the ongoing Northern Manhattan Family Study (NOMAFS), which studies the contribution of genetics to stroke and cardiovascular risk factors. The age- and sex-adjusted heritability of FMD was estimated using variance component methods. Results: The current data include 620 subjects (97 probands and 523 relatives) from 97 families. The age and sex-adjusted heritability of brachial artery diameter was 0.57 (p < 0.01). The age- and sex-adjusted heritability of FMD was 0.20 (p = 0.01). After additional adjustment for systolic and diastolic blood pressure, body mass index, smoking, lipid, diabetes mellitus, medication, and baseline brachial artery diameter, the heritability of FMD was 0.17 (p = 0.01). Conclusions: We found modest heritability of FMD. FMD might be a reasonable phenotype for further investigation of genetic contribution to atherosclerosis.

Original languageEnglish (US)
Pages (from-to)212-216
Number of pages5
JournalAtherosclerosis
Volume197
Issue number1
DOIs
StatePublished - Mar 2008

Fingerprint

Brachial Artery
Dilatation
Hispanic Americans
Blood Pressure
Atherosclerosis
Diabetes Mellitus
Body Mass Index
Cardiovascular Diseases
Smoking
Myocardial Infarction
Phenotype
Lipids

Keywords

  • Atherosclerosis
  • Endothelial function
  • Flow-mediated dilation
  • Genetics
  • Heritability

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Genetic contribution to brachial artery flow-mediated dilation : The Northern Manhattan Family Study. / Suzuki, Keiko; Juo, Suh Hang Hank; Rundek, Tanja; Boden-Albala, Bernadette; Disla, Norbelina; Liu, Rui; Park, Naeun; Di Tullio, Marco R.; Sacco, Ralph L.; Homma, Shunichi.

In: Atherosclerosis, Vol. 197, No. 1, 03.2008, p. 212-216.

Research output: Contribution to journalArticle

Suzuki, K, Juo, SHH, Rundek, T, Boden-Albala, B, Disla, N, Liu, R, Park, N, Di Tullio, MR, Sacco, RL & Homma, S 2008, 'Genetic contribution to brachial artery flow-mediated dilation: The Northern Manhattan Family Study', Atherosclerosis, vol. 197, no. 1, pp. 212-216. https://doi.org/10.1016/j.atherosclerosis.2007.03.023
Suzuki, Keiko ; Juo, Suh Hang Hank ; Rundek, Tanja ; Boden-Albala, Bernadette ; Disla, Norbelina ; Liu, Rui ; Park, Naeun ; Di Tullio, Marco R. ; Sacco, Ralph L. ; Homma, Shunichi. / Genetic contribution to brachial artery flow-mediated dilation : The Northern Manhattan Family Study. In: Atherosclerosis. 2008 ; Vol. 197, No. 1. pp. 212-216.
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AU - Liu, Rui

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AB - Background: Brachial artery flow-mediated dilation (FMD) is a non-invasive measure of endothelial function. Endothelial dysfunction has been associated with traditional vascular risk factors and increased risk of cardiovascular disease. The importance of genetic contribution to FMD and baseline brachial artery diameter has not been shown in Hispanic populations. The purpose of this study was to estimate the heritability of FMD. Methods: Flow mediated dilation and brachial artery diameter were measured in a subset of Caribbean Hispanic families from the ongoing Northern Manhattan Family Study (NOMAFS), which studies the contribution of genetics to stroke and cardiovascular risk factors. The age- and sex-adjusted heritability of FMD was estimated using variance component methods. Results: The current data include 620 subjects (97 probands and 523 relatives) from 97 families. The age and sex-adjusted heritability of brachial artery diameter was 0.57 (p < 0.01). The age- and sex-adjusted heritability of FMD was 0.20 (p = 0.01). After additional adjustment for systolic and diastolic blood pressure, body mass index, smoking, lipid, diabetes mellitus, medication, and baseline brachial artery diameter, the heritability of FMD was 0.17 (p = 0.01). Conclusions: We found modest heritability of FMD. FMD might be a reasonable phenotype for further investigation of genetic contribution to atherosclerosis.

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