Genetic and environmental risks for high blood pressure among african american mothers and daughters

Jacquelyn Taylor, Rosanna Maddox, Wu Chun Yi

Research output: Contribution to journalArticle

Abstract

Objective: To determine the relationship between genetic and environmental lifestyle factors (physical activity and sodium) on blood pressure (BP) among African-American women. Method: In this cross-sectional study involving 108 African-American mothers and daughters from a Midwestern area, investigators obtained BP measurements, information on minutes of physical activity, amount of sodium intake, and buccal swab saliva samples. Results: Of the 4 single nucleotide polymorphisms (SNPs) on the sodium bicarbonate cotransporter gene (SLC4A5), rs8179526 had a statistically significant interaction with cytosine/thymine (C/T) genotype by sodium status on systolic BP (SBP; p =.0077). For gene - physical activity interaction, 2 significant interactions (cytosine/adenine [C/A] genotype by physical activity and adenine/adenine [A/A] genotype by physical activity, p =.0107 and p =.0171, respectively) on SBP and 1 on diastolic BP (DBP; A/A genotype by physical activity, p =.0233) were found on rs1017783. Two significant guanine/adenine [G/A] genotype by physical activity interactions were found on rs6731545 for SBP and DBP (p =.0160 and p =.0492, respectively). Discussion: A gene - environmental interaction with rs8179526 has a protective effect on SBP in African-American women with high sodium intake. Participants with C/T genotype of rs8179526 who consumed greater than 2,300 mg of sodium had lower SBP than those who consumed less than recommended. Women with thymine/thymine (T/T) genotype of rs8179526 who consumed greater than 2,300 mg had lower SBP than those who consumed less. Awareness of both the protective and deleterious properties of rs8179526 in African-American women may one day assist in determining appropriate treatment plans.

Original languageEnglish (US)
Pages (from-to)53-65
Number of pages13
JournalBiological Research for Nursing
Volume11
Issue number1
DOIs
StatePublished - Jul 1 2009

Fingerprint

Nuclear Family
African Americans
Adenine
Genotype
Mothers
Exercise
Thymine
Hypertension
Blood Pressure
Sodium
Cytosine
Sodium-Bicarbonate Symporters
Genes
Cheek
Guanine
Saliva
Single Nucleotide Polymorphism
Life Style
Cross-Sectional Studies
Research Personnel

Keywords

  • African-American women
  • Gene-environment
  • High BP

ASJC Scopus subject areas

  • Research and Theory

Cite this

Genetic and environmental risks for high blood pressure among african american mothers and daughters. / Taylor, Jacquelyn; Maddox, Rosanna; Chun Yi, Wu.

In: Biological Research for Nursing, Vol. 11, No. 1, 01.07.2009, p. 53-65.

Research output: Contribution to journalArticle

@article{a5a141f307c24903b2f0d182e8d88981,
title = "Genetic and environmental risks for high blood pressure among african american mothers and daughters",
abstract = "Objective: To determine the relationship between genetic and environmental lifestyle factors (physical activity and sodium) on blood pressure (BP) among African-American women. Method: In this cross-sectional study involving 108 African-American mothers and daughters from a Midwestern area, investigators obtained BP measurements, information on minutes of physical activity, amount of sodium intake, and buccal swab saliva samples. Results: Of the 4 single nucleotide polymorphisms (SNPs) on the sodium bicarbonate cotransporter gene (SLC4A5), rs8179526 had a statistically significant interaction with cytosine/thymine (C/T) genotype by sodium status on systolic BP (SBP; p =.0077). For gene - physical activity interaction, 2 significant interactions (cytosine/adenine [C/A] genotype by physical activity and adenine/adenine [A/A] genotype by physical activity, p =.0107 and p =.0171, respectively) on SBP and 1 on diastolic BP (DBP; A/A genotype by physical activity, p =.0233) were found on rs1017783. Two significant guanine/adenine [G/A] genotype by physical activity interactions were found on rs6731545 for SBP and DBP (p =.0160 and p =.0492, respectively). Discussion: A gene - environmental interaction with rs8179526 has a protective effect on SBP in African-American women with high sodium intake. Participants with C/T genotype of rs8179526 who consumed greater than 2,300 mg of sodium had lower SBP than those who consumed less than recommended. Women with thymine/thymine (T/T) genotype of rs8179526 who consumed greater than 2,300 mg had lower SBP than those who consumed less. Awareness of both the protective and deleterious properties of rs8179526 in African-American women may one day assist in determining appropriate treatment plans.",
keywords = "African-American women, Gene-environment, High BP",
author = "Jacquelyn Taylor and Rosanna Maddox and {Chun Yi}, Wu",
year = "2009",
month = "7",
day = "1",
doi = "10.1177/1099800409334817",
language = "English (US)",
volume = "11",
pages = "53--65",
journal = "Biological Research for Nursing",
issn = "1099-8004",
publisher = "SAGE Publications Inc.",
number = "1",

}

TY - JOUR

T1 - Genetic and environmental risks for high blood pressure among african american mothers and daughters

AU - Taylor, Jacquelyn

AU - Maddox, Rosanna

AU - Chun Yi, Wu

PY - 2009/7/1

Y1 - 2009/7/1

N2 - Objective: To determine the relationship between genetic and environmental lifestyle factors (physical activity and sodium) on blood pressure (BP) among African-American women. Method: In this cross-sectional study involving 108 African-American mothers and daughters from a Midwestern area, investigators obtained BP measurements, information on minutes of physical activity, amount of sodium intake, and buccal swab saliva samples. Results: Of the 4 single nucleotide polymorphisms (SNPs) on the sodium bicarbonate cotransporter gene (SLC4A5), rs8179526 had a statistically significant interaction with cytosine/thymine (C/T) genotype by sodium status on systolic BP (SBP; p =.0077). For gene - physical activity interaction, 2 significant interactions (cytosine/adenine [C/A] genotype by physical activity and adenine/adenine [A/A] genotype by physical activity, p =.0107 and p =.0171, respectively) on SBP and 1 on diastolic BP (DBP; A/A genotype by physical activity, p =.0233) were found on rs1017783. Two significant guanine/adenine [G/A] genotype by physical activity interactions were found on rs6731545 for SBP and DBP (p =.0160 and p =.0492, respectively). Discussion: A gene - environmental interaction with rs8179526 has a protective effect on SBP in African-American women with high sodium intake. Participants with C/T genotype of rs8179526 who consumed greater than 2,300 mg of sodium had lower SBP than those who consumed less than recommended. Women with thymine/thymine (T/T) genotype of rs8179526 who consumed greater than 2,300 mg had lower SBP than those who consumed less. Awareness of both the protective and deleterious properties of rs8179526 in African-American women may one day assist in determining appropriate treatment plans.

AB - Objective: To determine the relationship between genetic and environmental lifestyle factors (physical activity and sodium) on blood pressure (BP) among African-American women. Method: In this cross-sectional study involving 108 African-American mothers and daughters from a Midwestern area, investigators obtained BP measurements, information on minutes of physical activity, amount of sodium intake, and buccal swab saliva samples. Results: Of the 4 single nucleotide polymorphisms (SNPs) on the sodium bicarbonate cotransporter gene (SLC4A5), rs8179526 had a statistically significant interaction with cytosine/thymine (C/T) genotype by sodium status on systolic BP (SBP; p =.0077). For gene - physical activity interaction, 2 significant interactions (cytosine/adenine [C/A] genotype by physical activity and adenine/adenine [A/A] genotype by physical activity, p =.0107 and p =.0171, respectively) on SBP and 1 on diastolic BP (DBP; A/A genotype by physical activity, p =.0233) were found on rs1017783. Two significant guanine/adenine [G/A] genotype by physical activity interactions were found on rs6731545 for SBP and DBP (p =.0160 and p =.0492, respectively). Discussion: A gene - environmental interaction with rs8179526 has a protective effect on SBP in African-American women with high sodium intake. Participants with C/T genotype of rs8179526 who consumed greater than 2,300 mg of sodium had lower SBP than those who consumed less than recommended. Women with thymine/thymine (T/T) genotype of rs8179526 who consumed greater than 2,300 mg had lower SBP than those who consumed less. Awareness of both the protective and deleterious properties of rs8179526 in African-American women may one day assist in determining appropriate treatment plans.

KW - African-American women

KW - Gene-environment

KW - High BP

UR - http://www.scopus.com/inward/record.url?scp=67949109636&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67949109636&partnerID=8YFLogxK

U2 - 10.1177/1099800409334817

DO - 10.1177/1099800409334817

M3 - Article

VL - 11

SP - 53

EP - 65

JO - Biological Research for Nursing

JF - Biological Research for Nursing

SN - 1099-8004

IS - 1

ER -