Genetic and environmental contributions to neonatal brain structure

A twin study

John H. Gilmore, James Eric Schmitt, Rebecca C. Knickmeyer, Jeffrey K. Smith, Weili Lin, Martin Styner, Guido Gerig, Michael C. Neale

    Research output: Contribution to journalArticle

    Abstract

    Twin studies have found that global brain volumes, including total intracranial volume (ICV), total gray matter, and total white matter volumes are highly heritable in adults and older children. Very little is known about genetic and environmental contributions to brain structure in very young children and whether these contributions change over the course of development. We performed structural imaging on a 3T MR scanner of 217 neonatal twins, 41 same-sex monozygotic, 50 same-sex dizygotic pairs, and 35 "single" twins - neonates with brain scans unavailable for their co-twins. Tissue segmentation and parcellation was performed, and structural equation modeling was used to estimate additive genetic, common environmental, and unique environmental effects on brain structure. Heritability of ICV (0.73) and total white matter volume (0.85) was high and similar to that described in older children and adults; the heritability of total gray matter (0.56) was somewhat lower. Heritability of lateral ventricle volume was high (0.71), whereas the heritability of cerebellar volume was low (0.17). Comparison with previous twin studies in older children and adults reveal that three general patterns of how heritability can change during postnatal brain development: (1) for global white matter volumes, heritability is comparable to reported heritability in adults, (2) for global gray matter volume and cerebellar volume, heritability increases with age, and (3) for lateral ventricle volume, heritability decreases with age. More detailed studies of the changes in the relative genetic and environmental effects on brain structure throughout early childhood development are needed.

    Original languageEnglish (US)
    Pages (from-to)1174-1182
    Number of pages9
    JournalHuman Brain Mapping
    Volume31
    Issue number8
    DOIs
    StatePublished - Aug 2010

    Fingerprint

    Twin Studies
    Brain
    Lateral Ventricles
    Newborn Infant
    White Matter
    Gray Matter

    Keywords

    • Cerebellum
    • Cortex
    • Gray matter
    • Lateral ventricle
    • Magnetic resonance imaging
    • Structural equation modeling
    • White matter

    ASJC Scopus subject areas

    • Clinical Neurology
    • Anatomy
    • Neurology
    • Radiology Nuclear Medicine and imaging
    • Radiological and Ultrasound Technology

    Cite this

    Gilmore, J. H., Schmitt, J. E., Knickmeyer, R. C., Smith, J. K., Lin, W., Styner, M., ... Neale, M. C. (2010). Genetic and environmental contributions to neonatal brain structure: A twin study. Human Brain Mapping, 31(8), 1174-1182. https://doi.org/10.1002/hbm.20926

    Genetic and environmental contributions to neonatal brain structure : A twin study. / Gilmore, John H.; Schmitt, James Eric; Knickmeyer, Rebecca C.; Smith, Jeffrey K.; Lin, Weili; Styner, Martin; Gerig, Guido; Neale, Michael C.

    In: Human Brain Mapping, Vol. 31, No. 8, 08.2010, p. 1174-1182.

    Research output: Contribution to journalArticle

    Gilmore, JH, Schmitt, JE, Knickmeyer, RC, Smith, JK, Lin, W, Styner, M, Gerig, G & Neale, MC 2010, 'Genetic and environmental contributions to neonatal brain structure: A twin study', Human Brain Mapping, vol. 31, no. 8, pp. 1174-1182. https://doi.org/10.1002/hbm.20926
    Gilmore JH, Schmitt JE, Knickmeyer RC, Smith JK, Lin W, Styner M et al. Genetic and environmental contributions to neonatal brain structure: A twin study. Human Brain Mapping. 2010 Aug;31(8):1174-1182. https://doi.org/10.1002/hbm.20926
    Gilmore, John H. ; Schmitt, James Eric ; Knickmeyer, Rebecca C. ; Smith, Jeffrey K. ; Lin, Weili ; Styner, Martin ; Gerig, Guido ; Neale, Michael C. / Genetic and environmental contributions to neonatal brain structure : A twin study. In: Human Brain Mapping. 2010 ; Vol. 31, No. 8. pp. 1174-1182.
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