Genetic and activity-dependent mechanisms underlying interneuron diversity

Brie Wamsley, Gordon Fishell

    Research output: Contribution to journalReview article

    Abstract

    The proper construction of neural circuits requires the generation of diverse cell types, their distribution to defined regions, and their specific and appropriate wiring. A major objective in neurobiology has been to understand the molecular determinants that link neural birth to terminal specification and functional connectivity, a task that is especially daunting in the case of cortical interneurons. Considerable evidence supports the idea that an interplay of intrinsic and environmental signalling is crucial to the sequential steps of interneuron specification, including migration, selection of a settling position, morphogenesis and synaptogenesis. However, when and how these influences merge to support the appropriate terminal differentiation of different classes of interneurons remains uncertain. In this Review, we discuss a wealth of recent findings that have advanced our understanding of the developmental mechanisms that contribute to the diversification of interneurons and suggest areas of particular promise for further investigation.

    Original languageEnglish (US)
    Pages (from-to)299-309
    Number of pages11
    JournalNature Reviews Neuroscience
    Volume18
    Issue number5
    DOIs
    StatePublished - May 1 2017

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    Interneurons
    Neurobiology
    Morphogenesis
    Parturition

    ASJC Scopus subject areas

    • Neuroscience(all)

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    Genetic and activity-dependent mechanisms underlying interneuron diversity. / Wamsley, Brie; Fishell, Gordon.

    In: Nature Reviews Neuroscience, Vol. 18, No. 5, 01.05.2017, p. 299-309.

    Research output: Contribution to journalReview article

    Wamsley, Brie ; Fishell, Gordon. / Genetic and activity-dependent mechanisms underlying interneuron diversity. In: Nature Reviews Neuroscience. 2017 ; Vol. 18, No. 5. pp. 299-309.
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