Genes to remember

Research output: Contribution to journalArticle

Abstract

It has been known for several decades that the formation of long-term memory requires gene expression. In recent years, the use of genetic and molecular approaches has led to the identification and characterization of genes and molecules that play a fundamental role in the biological mechanisms underlying learning and memory. From these studies, it appears that molecules and molecular mechanisms essential for the process of memory have been conserved throughout evolution. The cyclic AMP (cAMP)dependent activation pathway and a cAMP-dependent cascade of gene expression have been shown to be essential for memory formation in Aplysia californica, Drosophila melanogaster and rodents. Moreover, members of the transcription factor family cAMP response element binding proteins (CREBs) seem to represent key molecules for transforming incoming information into long-term memory. Here, we review the studies showing that conserved molecules and biological mechanisms are engaged in simple and complex forms of memory.

Original languageEnglish (US)
Pages (from-to)2887-2891
Number of pages5
JournalJournal of Experimental Biology
Volume202
Issue number21
StatePublished - Nov 1999

Fingerprint

Long-Term Memory
gene
cyclic AMP
Cyclic AMP
Genes
genes
Gene Expression
Aplysia
Cyclic AMP Response Element-Binding Protein
gene expression
Drosophila melanogaster
Molecular Biology
Rodentia
Transcription Factors
response elements
Learning
rodent
binding proteins
rodents
learning

Keywords

  • cAMP
  • CREB
  • Gene
  • Learning
  • Memory
  • Transcription factor

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)

Cite this

Genes to remember. / Alberini, Cristina.

In: Journal of Experimental Biology, Vol. 202, No. 21, 11.1999, p. 2887-2891.

Research output: Contribution to journalArticle

Alberini, C 1999, 'Genes to remember', Journal of Experimental Biology, vol. 202, no. 21, pp. 2887-2891.
Alberini, Cristina. / Genes to remember. In: Journal of Experimental Biology. 1999 ; Vol. 202, No. 21. pp. 2887-2891.
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