Generation of uniform fly retinas

Mathias F. Wernet, Arzu Çelik, Tamara Mikeladze-Dvali, Claude Desplan

Research output: Contribution to journalArticle

Abstract

The compound eye of Drosophila melanogaster is composed of about 800 ommatidial units, each containing eight photoreceptor cells (R1-R8). Based on their spectral sensitivities, three subtypes can be distinguished [1]: The 'pale' (p) and 'yellow' (y) ommatidia [2] are distributed randomly throughout the main part of the eye (Figure 1A). They show different spectral sensitivity, at shorter and longer wavelengths, respectively. The third subtype, consisting of morphologically distinct ommatidia with monochromatic inner photoreceptors, is found in a narrow stripe at the dorsal rim (DRA) of the adult eye and probably detects polarized light [3]. Here, we completely re-designed the stochastic p/y mosaic by manipulating only three genes: spineless [4], the growth regulator melted, and the tumor suppressor warts/lats [5]. By enforcing unambiguous cell fate decisions independently in both R7 and R8 cells, completely homogeneous retinas consisting of only one ommatidial subtype can be created, including unusual opsin combinations that never occur in the wild type.

Original languageEnglish (US)
JournalCurrent Biology
Volume17
Issue number23
DOIs
StatePublished - Dec 4 2007

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Opsins
Light polarization
retina
Diptera
Retina
ommatidia
Tumors
Genes
photoreceptors
Wavelength
eyes
opsin
warts
Photoreceptor Cells
Warts
polarized light
compound eyes
cells
Drosophila melanogaster
growth regulators

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Generation of uniform fly retinas. / Wernet, Mathias F.; Çelik, Arzu; Mikeladze-Dvali, Tamara; Desplan, Claude.

In: Current Biology, Vol. 17, No. 23, 04.12.2007.

Research output: Contribution to journalArticle

Wernet, MF, Çelik, A, Mikeladze-Dvali, T & Desplan, C 2007, 'Generation of uniform fly retinas', Current Biology, vol. 17, no. 23. https://doi.org/10.1016/j.cub.2007.10.006
Wernet, Mathias F. ; Çelik, Arzu ; Mikeladze-Dvali, Tamara ; Desplan, Claude. / Generation of uniform fly retinas. In: Current Biology. 2007 ; Vol. 17, No. 23.
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