Generation and delivery of monodisperse pico-liter droplets out of PDMS microchip into Accelerator Mass Spectrometry (AMS)

Sung Jae Kim, Rafael Song, Paul L. Skipper, Steven R. Tannenbaum, Jongyoon Han

Research output: Contribution to conferencePaper

Abstract

We have developed a drop-on-demand microdroplet generator for the discrete dispensing of bio-samples into a bio-analytical unit, Accelerator Mass Spectrometry (AMS). The disposable PDMS microfluidic device can generate monodisperse droplets of pico-liter volume directly out of a plane sidewall of the microfluidic chip by an electrohydrodynamic mechanism. The droplet generation was accomplished without using either an inserted capillary or built-in tip. The minimum droplet volume was around 4 pico-liters, and the droplet generation was repeatable and stable for at least 30 minutes, with a typical variation of less than 2.0% of drop size. A computational simulation of the droplet generation verified the importance of controlling the surface wetting conditions for the droplet formation. Our microdroplet generator can be effective interfacing mechanism from a microfluidic chip to a non-chip bio-sensing unit, such as AMS or MALDI-MS.

Original languageEnglish (US)
Pages1076-1078
Number of pages3
StatePublished - Jan 1 2006
Event10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 - Tokyo, Japan
Duration: Nov 5 2006Nov 9 2006

Other

Other10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006
CountryJapan
CityTokyo
Period11/5/0611/9/06

Fingerprint

Particle accelerators
Mass spectrometry
Microfluidics
Electrohydrodynamics
Wetting

Keywords

  • AMS
  • Drop-on-demand dispenser
  • EHD
  • Microdroplet generator
  • PDMS microchip

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Kim, S. J., Song, R., Skipper, P. L., Tannenbaum, S. R., & Han, J. (2006). Generation and delivery of monodisperse pico-liter droplets out of PDMS microchip into Accelerator Mass Spectrometry (AMS). 1076-1078. Paper presented at 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006, Tokyo, Japan.

Generation and delivery of monodisperse pico-liter droplets out of PDMS microchip into Accelerator Mass Spectrometry (AMS). / Kim, Sung Jae; Song, Rafael; Skipper, Paul L.; Tannenbaum, Steven R.; Han, Jongyoon.

2006. 1076-1078 Paper presented at 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006, Tokyo, Japan.

Research output: Contribution to conferencePaper

Kim, SJ, Song, R, Skipper, PL, Tannenbaum, SR & Han, J 2006, 'Generation and delivery of monodisperse pico-liter droplets out of PDMS microchip into Accelerator Mass Spectrometry (AMS)' Paper presented at 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006, Tokyo, Japan, 11/5/06 - 11/9/06, pp. 1076-1078.
Kim SJ, Song R, Skipper PL, Tannenbaum SR, Han J. Generation and delivery of monodisperse pico-liter droplets out of PDMS microchip into Accelerator Mass Spectrometry (AMS). 2006. Paper presented at 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006, Tokyo, Japan.
Kim, Sung Jae ; Song, Rafael ; Skipper, Paul L. ; Tannenbaum, Steven R. ; Han, Jongyoon. / Generation and delivery of monodisperse pico-liter droplets out of PDMS microchip into Accelerator Mass Spectrometry (AMS). Paper presented at 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006, Tokyo, Japan.3 p.
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