Gene-environment interactions between arsenic exposure from drinking water and genetic susceptibility in cardiovascular disease risk and carotid artery intima-media thickness in Bangladesh

F. Wu, M. L. Liu, X. Cheng, J. Y. Jiang, Y. Chen, F. Parvez, V. Slavkovich, D. Levy, J. H. Graziano, F. Jasmine, M. G. Kibriya, H. Ahsan, T. Islam, A. Ahmed, M. Rakibuz-Zaman, S. Roy, R. Paul-Brutus

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Arsenic exposure from drinking water has been linked to subclinical and clinical outcomes of cardiovascular disease (CVD). However, no large-scale studies have evaluated whether the cardiovascular effects of arsenic exposure could be modified by genetic factors. Using data from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh, we evaluated whether the association between arsenic exposure and CVD risk or carotid artery Intima-Media Thickness (cIMT) differs by single-nucleotide polymorphisms (SNPs) in 18 genes related to arsenic metabolism, oxidative stress, and inflammation and endothelial dysfunction. We found significant interactions between well-water As and two SNPs in ICAM1 and VCAM1 in CVD risk, and of both well-water As and urinary As with 3 SNPs in AS3MT in cIMT. Our data provide novel evidence that the cardiovascular effects of arsenic exposure may vary with some common genetic variants in genes related to arsenic metabolism and endothelial dysfunction.

Original languageEnglish (US)
Title of host publicationOne Century of the Discovery of Arsenicosis in Latin America (1914-2014)
Subtitle of host publicationAs 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment
PublisherCRC Press/Balkema
Pages610-612
Number of pages3
ISBN (Print)9781138001411
StatePublished - Jan 1 2014
Event5th International Congress on Arsenic in the Environment, As 2014 - Buenos Aires, Argentina
Duration: May 11 2014May 16 2014

Publication series

NameOne Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment

Other

Other5th International Congress on Arsenic in the Environment, As 2014
CountryArgentina
CityBuenos Aires
Period5/11/145/16/14

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ASJC Scopus subject areas

  • Chemical Health and Safety

Cite this

Wu, F., Liu, M. L., Cheng, X., Jiang, J. Y., Chen, Y., Parvez, F., Slavkovich, V., Levy, D., Graziano, J. H., Jasmine, F., Kibriya, M. G., Ahsan, H., Islam, T., Ahmed, A., Rakibuz-Zaman, M., Roy, S., & Paul-Brutus, R. (2014). Gene-environment interactions between arsenic exposure from drinking water and genetic susceptibility in cardiovascular disease risk and carotid artery intima-media thickness in Bangladesh. In One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment (pp. 610-612). (One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment). CRC Press/Balkema.