Gain Modulation by Nicotine in Macaque V1

Anita A. Disney, Chiye Aoki, Michael Hawken

Research output: Contribution to journalArticle

Abstract

Acetylcholine is a ubiquitous cortical neuromodulator implicated in cognition. In order to understand the potential for acetylcholine to play a role in visual attention, we studied nicotinic acetylcholine receptor (nAChR) localization and function in area V1 of the macaque. We found nAChRs presynaptically at thalamic synapses onto excitatory, but not inhibitory, neurons in the primary thalamorecipient layer 4c. Furthermore, consistent with the release enhancement suggested by this localization, we discovered that nicotine increases responsiveness and lowers contrast threshold in layer 4c neurons. We also found that nAChRs are expressed by GABAergic interneurons in V1 but rarely by pyramidal neurons, and that nicotine suppresses visual responses outside layer 4c. All sensory systems incorporate gain control mechanisms, or processes which dynamically alter input/output relationships. We demonstrate that at the site of thalamic input to visual cortex, the effect of this nAChR-mediated gain is an enhancement of the detection of visual stimuli.

Original languageEnglish (US)
Pages (from-to)701-713
Number of pages13
JournalNeuron
Volume56
Issue number4
DOIs
StatePublished - Nov 21 2007

Fingerprint

Nicotinic Receptors
Macaca
Nicotine
Acetylcholine
Neurons
Pyramidal Cells
Interneurons
Visual Cortex
Synapses
Cognition
Neurotransmitter Agents

Keywords

  • SIGNALING
  • SYSNEURO

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Gain Modulation by Nicotine in Macaque V1. / Disney, Anita A.; Aoki, Chiye; Hawken, Michael.

In: Neuron, Vol. 56, No. 4, 21.11.2007, p. 701-713.

Research output: Contribution to journalArticle

Disney, Anita A. ; Aoki, Chiye ; Hawken, Michael. / Gain Modulation by Nicotine in Macaque V1. In: Neuron. 2007 ; Vol. 56, No. 4. pp. 701-713.
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