GABAergic inhibition gates excitatory LTP in perirhinal cortex

Vibhakar C. Kotak, Ana Mirallave, Todd M. Mowery, Dan Sanes

Research output: Contribution to journalArticle

Abstract

The perirhinal cortex (PRh) is a key region downstream of auditory cortex (ACx) that processes familiarity linked mnemonic signaling. In gerbils, ACx-driven EPSPs recorded in PRh neurons are largely shunted by GABAergic inhibition (Kotak et al., 2015, Frontiers in Neural Circuits, 9). To determine whether inhibitory shunting prevents the induction of excitatory long-term potentiation (e-LTP), we stimulated ACx-recipient PRh in a brain slice preparation using theta burst stimulation (TBS). Under control conditions, without GABA blockers, the majority of PRh neurons exhibited long-term depression. A very low concentration of bicuculline increased EPSP amplitude, but under this condition TBS did not significantly increase e-LTP induction. Since PRh synaptic inhibition included a GABAB receptor-mediated component, we added a GABAB receptor antagonist. When both GABAA and GABAB receptors were blocked, TBS reliably induced e-LTP in a majority of PRh neurons. We conclude that GABAergic transmission is a vital mechanism regulating e-LTP induction in the PRh, and may be associated with auditory learning.

Original languageEnglish (US)
Pages (from-to)1217-1223
Number of pages7
JournalHippocampus
Volume27
Issue number12
DOIs
StatePublished - Dec 1 2017

Fingerprint

Long-Term Potentiation
Auditory Cortex
Excitatory Postsynaptic Potentials
Neurons
Bicuculline
Gerbillinae
GABA-A Receptors
Inhibition (Psychology)
Perirhinal Cortex
gamma-Aminobutyric Acid
Learning
Depression
Brain

Keywords

  • auditory cortex
  • GABAA receptor
  • GABAB receptor
  • LTP
  • perirhinal cortex

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

GABAergic inhibition gates excitatory LTP in perirhinal cortex. / Kotak, Vibhakar C.; Mirallave, Ana; Mowery, Todd M.; Sanes, Dan.

In: Hippocampus, Vol. 27, No. 12, 01.12.2017, p. 1217-1223.

Research output: Contribution to journalArticle

Kotak, VC, Mirallave, A, Mowery, TM & Sanes, D 2017, 'GABAergic inhibition gates excitatory LTP in perirhinal cortex', Hippocampus, vol. 27, no. 12, pp. 1217-1223. https://doi.org/10.1002/hipo.22799
Kotak, Vibhakar C. ; Mirallave, Ana ; Mowery, Todd M. ; Sanes, Dan. / GABAergic inhibition gates excitatory LTP in perirhinal cortex. In: Hippocampus. 2017 ; Vol. 27, No. 12. pp. 1217-1223.
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