GABAB and Trk receptor signaling mediates long-lasting inhibitory synaptic depression

Vibhakar C. Kotak, Christopher Dimattina, Dan Sanes

Research output: Contribution to journalArticle

Abstract

In many areas of the nervous system, excitatory and inhibitory synapses are reconfigured during early development. We have previously described the anatomical refinement of an inhibitory projection from the medial nucleus of the trapezoid body to the lateral superior olive in the developing gerbil auditory brain stem. Furthermore, these inhibitory synapses display an age-dependent form of long-lasting depression when activated at a low rate, suggesting that this process could support inhibitory synaptic refinement. Since the inhibitory synapses release both glycine and GABA during maturation, we tested whether GABAB receptor signaling could initiate the decrease in synaptic strength. When whole cell recordings were made from lateral superior olive neurons in a brain slice preparation, the long-lasting depression of medial nucleus of the trapezoid body-evoked inhibitory potentials was eliminated by the GABAB receptor antagonist, SCH-50911. In addition, inhibitory potentials could be depressed by repeated exposure to the GABAB receptor agonist, baclofen. Since GABAB receptor signaling may not account entirely for inhibitory synaptic depression, we examined the influence of neurotrophin signaling pathways located in the developing superior olive. Bath application of brainderived neurotrophic factor or neurotrophin-3 depressed evoked inhibitory potentials, and use-dependent depression was blocked by the tyrosine kinase antagonist, K-252a. We suggest that early expression of GABAergic and neurotrophin signaling mediates inhibitory synaptic plasticity, and this mechanism may support the anatomical refinement of inhibitory connections.

Original languageEnglish (US)
Pages (from-to)536-540
Number of pages5
JournalJournal of Neurophysiology
Volume86
Issue number1
StatePublished - 2001

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Nerve Growth Factors
Synapses
Evoked Potentials
GABA-B Receptors
Neurotrophin 3
Neuronal Plasticity
Gerbillinae
Patch-Clamp Techniques
Baths
Protein-Tyrosine Kinases
Glycine
gamma-Aminobutyric Acid
Nervous System
Brain Stem
Neurons
Brain
Superior Olivary Complex
Trapezoid Body

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

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GABAB and Trk receptor signaling mediates long-lasting inhibitory synaptic depression. / Kotak, Vibhakar C.; Dimattina, Christopher; Sanes, Dan.

In: Journal of Neurophysiology, Vol. 86, No. 1, 2001, p. 536-540.

Research output: Contribution to journalArticle

Kotak, Vibhakar C. ; Dimattina, Christopher ; Sanes, Dan. / GABAB and Trk receptor signaling mediates long-lasting inhibitory synaptic depression. In: Journal of Neurophysiology. 2001 ; Vol. 86, No. 1. pp. 536-540.
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