Functionalization of polymer microspheres using click chemistry

Dana R. Breed, Raymond Thibault, Fang Xie, Qian Wang, Craig J. Hawker, David J. Pine

Research output: Contribution to journalArticle

Abstract

We describe a new method to covalently link a wide variety of molecules to the surface of colloidal polymer microspheres using the Cu(I)-catalyzed azide-alkyne reaction, most commonly known under the class of reactions identified by the term click chemistry. The method is generic and readily applied to a spectrum of colloidal particle systems allowing surfaces to be tailored with virtually any desired functionality. To demonstrate this method, polystyrene microspheres were functionalized with two different polyethylene oxide-based polymers, and changes in hydrodynamic radii after functionalization were measured using dynamic light scattering. Control of surface functional groups was demonstrated by fluorescently labeling the colloidal microspheres using the same Cu-catalyzed azide-alkyne cycloaddition reaction.

Original languageEnglish (US)
Pages (from-to)4370-4376
Number of pages7
JournalLangmuir
Volume25
Issue number8
DOIs
StatePublished - Apr 21 2009

Fingerprint

Microspheres
Polymers
Alkynes
Azides
alkynes
chemistry
polymers
Cycloaddition
Polystyrenes
cycloaddition
Dynamic light scattering
Polyethylene oxides
Labeling
Functional groups
marking
polyethylenes
polystyrene
light scattering
Hydrodynamics
hydrodynamics

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy

Cite this

Breed, D. R., Thibault, R., Xie, F., Wang, Q., Hawker, C. J., & Pine, D. J. (2009). Functionalization of polymer microspheres using click chemistry. Langmuir, 25(8), 4370-4376. https://doi.org/10.1021/la801880u

Functionalization of polymer microspheres using click chemistry. / Breed, Dana R.; Thibault, Raymond; Xie, Fang; Wang, Qian; Hawker, Craig J.; Pine, David J.

In: Langmuir, Vol. 25, No. 8, 21.04.2009, p. 4370-4376.

Research output: Contribution to journalArticle

Breed, DR, Thibault, R, Xie, F, Wang, Q, Hawker, CJ & Pine, DJ 2009, 'Functionalization of polymer microspheres using click chemistry', Langmuir, vol. 25, no. 8, pp. 4370-4376. https://doi.org/10.1021/la801880u
Breed DR, Thibault R, Xie F, Wang Q, Hawker CJ, Pine DJ. Functionalization of polymer microspheres using click chemistry. Langmuir. 2009 Apr 21;25(8):4370-4376. https://doi.org/10.1021/la801880u
Breed, Dana R. ; Thibault, Raymond ; Xie, Fang ; Wang, Qian ; Hawker, Craig J. ; Pine, David J. / Functionalization of polymer microspheres using click chemistry. In: Langmuir. 2009 ; Vol. 25, No. 8. pp. 4370-4376.
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