Functional outcomes of pediatric liver transplantation

Estella M. Alonso, K. Neighbors, C. Mattson, E. Sweet, H. Ruch-Ross, Carolyn Berry, J. Sinacore

Research output: Contribution to journalArticle

Abstract

The functional status and health-related quality of life (HRQOL) of children who survive liver transplantation (LT) have not been well documented. The purpose of this study was to determine the functional status and HRQOL in this population using a validated measure for children, the Child Health Questionnaire-Parent Form 50 (CHQ-PF50). Methods: The CHQ-PF50 instrument was completed by the parents of 55 children who agreed to participate in a mailing survey. Subscale scores for the sample were compared with those of a published normal population (n = 391). Results: Study sample characteristics were: 87% Caucasian, 54.5% female, mean age at survey was 9.6 years (range, 5-17 years). Responding caregivers were 95% biologic parents and 93% female. Compared with the normal population, LT recipients had lower subscale scores for general health perceptions (P < 0.0005), emotional impact on parents (<0.0005) and disruption of family activities (0.0005). The mean physical summary score of the LT recipients was lower than that of the normal population 48.1 ± 12.1 (P = 0.005), but the mean psychosocial summary score was similar 48.8 ± 11.9 (P = 0.156). Within the LT population, the original diagnosis (biliary atresia vs. other), type of LT (living donor vs. cadaveric), age at LT, z score for height, and hospital days did not significantly influence any of the subscale scores. Conclusions: Children who have survived LT have functional outcomes in the physical domain that are lower than those of normal children. Self-esteem and mental health in this group appeared normal. The parents in this sample experienced more emotional stress and disruption of family activities than did parents in a normal population.

Original languageEnglish (US)
Pages (from-to)155-160
Number of pages6
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume37
Issue number2
DOIs
StatePublished - Aug 2003

Fingerprint

liver transplant
Liver Transplantation
Pediatrics
Parents
Population
functional status
quality of life
questionnaires
Quality of Life
Biliary Atresia
self-esteem
mental health
Living Donors
abnormal development
health care workers
Psychological Stress
Self Concept
sampling
Caregivers
Mental Health

Keywords

  • Functional outcomes
  • Health-related quality of life
  • Pediatric liver transplantation

ASJC Scopus subject areas

  • Gastroenterology
  • Histology
  • Medicine (miscellaneous)
  • Food Science
  • Pediatrics, Perinatology, and Child Health

Cite this

Alonso, E. M., Neighbors, K., Mattson, C., Sweet, E., Ruch-Ross, H., Berry, C., & Sinacore, J. (2003). Functional outcomes of pediatric liver transplantation. Journal of Pediatric Gastroenterology and Nutrition, 37(2), 155-160. https://doi.org/10.1097/00005176-200308000-00014

Functional outcomes of pediatric liver transplantation. / Alonso, Estella M.; Neighbors, K.; Mattson, C.; Sweet, E.; Ruch-Ross, H.; Berry, Carolyn; Sinacore, J.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 37, No. 2, 08.2003, p. 155-160.

Research output: Contribution to journalArticle

Alonso, EM, Neighbors, K, Mattson, C, Sweet, E, Ruch-Ross, H, Berry, C & Sinacore, J 2003, 'Functional outcomes of pediatric liver transplantation', Journal of Pediatric Gastroenterology and Nutrition, vol. 37, no. 2, pp. 155-160. https://doi.org/10.1097/00005176-200308000-00014
Alonso, Estella M. ; Neighbors, K. ; Mattson, C. ; Sweet, E. ; Ruch-Ross, H. ; Berry, Carolyn ; Sinacore, J. / Functional outcomes of pediatric liver transplantation. In: Journal of Pediatric Gastroenterology and Nutrition. 2003 ; Vol. 37, No. 2. pp. 155-160.
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