Functional organization of primate translational vestibulo-ocular reflexes and effects of unilateral labyrinthectomy

Dora Angelaki, M. Quinn McHenry, Shawn D. Newlands, J. David Dickman

Research output: Contribution to journalArticle

Abstract

Translational vestibulo-ocular reflexes (trVORs) are characterized by distinct spatio-temporal properties and sensitivities that are proportional to the inverse of viewing distance. Anodal (inhibitory) labyrinthine stimulation (100 μA, < 2 s) during motion decreased the high-pass filtered dynamics, as well as horizontal trVOR sensitivity and its dependence on viewing distance. Cathodal (excitatory) currents had opposite effects. Translational VORs were also affected after unilateral labyrinthectomy. Animals lost their ability to modulate trVOR sensitivity as a function of viewing distance acutely after the lesion. These deficits partially recovered over time, albeit a significant reduction in trVOR sensitivity as a function of viewing distance remained in compensated animals. During fore-aft motion, the effects of unilateral labyrinthectomy were more dramatic. Both acute and compensated animals permanently lost their ability to modulate fore-aft trVOR responses as a function of target eccentricity. These results suggest that (1) the dynamics and viewing distance-dependent properties of the trVORs are very sensitive to changes in the resting firing rate of vestibular afferents and, consequently, vestibular nuclei neurons; (2) the most irregularly firing primary otolith afferents that are most sensitive to labyrinthine electrical stimulation might contribute to reflex dynamics and sensitivity; (3) inputs from both labyrinths are necessary for the generation of the translational VORs.

Original languageEnglish (US)
Pages (from-to)136-147
Number of pages12
JournalAnnals of the New York Academy of Sciences
Volume871
DOIs
StatePublished - Jan 1 1999

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Vestibulo-Ocular Reflex
Primates
Animals
Aptitude
Otolithic Membrane
Vestibular Nuclei
Inner Ear
Electric Stimulation
Neurons
Reflex

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Functional organization of primate translational vestibulo-ocular reflexes and effects of unilateral labyrinthectomy. / Angelaki, Dora; McHenry, M. Quinn; Newlands, Shawn D.; Dickman, J. David.

In: Annals of the New York Academy of Sciences, Vol. 871, 01.01.1999, p. 136-147.

Research output: Contribution to journalArticle

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