Functional interactions between oculomotor regions during prosaccades and antisaccades

Lee M. Miller, Felice T. Sun, Clayton Curtis, Mark D'Esposito

Research output: Contribution to journalArticle

Abstract

Human behavior reflects a continual negotiation of automatic and directed actions. The oculomotor network is a well-characterized neural system in which to study this balance of behavioral control. For instance, saccades made toward and away from a flashed visual stimulus (prosaccades and antisaccades, respectively) are known to engage different cognitive processes. Brain regions important for such controlled execution include the presupplementary motor area (pre-SMA), frontal eye fields (FEF), and intraparietal sulcus (IPS). Recent work has emphasized various elements of this network but has not explored the functional interactions among regions. We used event-related fMRI to image human brain activity during performance of an interleaved pro/antisaccade task. Since traditional univariate statistics cannot address issues of functional connectivity, a multivariate technique is necessary. Coherence between fMRI time series of the pre-SMA with the FEF and IPS was used to measure functional interactions. The FEF, but not IPS, showed significant differential coherence between pro- and antisaccade trials with pre-SMA. These results suggest that the pre-SMA coordinates with FEF to maintain a controlled, preparatory set for task-appropriate oculomotor execution.

Original languageEnglish (US)
Pages (from-to)119-127
Number of pages9
JournalHuman Brain Mapping
Volume26
Issue number2
DOIs
StatePublished - Oct 2005

Fingerprint

Motor Cortex
Frontal Lobe
Parietal Lobe
Magnetic Resonance Imaging
Saccades
Negotiating
Brain
Human Activities

Keywords

  • Coherence
  • Neural networks
  • Neuroimaging
  • Oculomotor control
  • Preparatory set

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Radiological and Ultrasound Technology

Cite this

Functional interactions between oculomotor regions during prosaccades and antisaccades. / Miller, Lee M.; Sun, Felice T.; Curtis, Clayton; D'Esposito, Mark.

In: Human Brain Mapping, Vol. 26, No. 2, 10.2005, p. 119-127.

Research output: Contribution to journalArticle

Miller, Lee M. ; Sun, Felice T. ; Curtis, Clayton ; D'Esposito, Mark. / Functional interactions between oculomotor regions during prosaccades and antisaccades. In: Human Brain Mapping. 2005 ; Vol. 26, No. 2. pp. 119-127.
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