Functional DNAzymes organized into two-dimensional arrays

Alejandra V. Garibotti, Scott M. Knudsen, Andrew D. Ellington, Nadrian Seeman

Research output: Contribution to journalArticle

Abstract

DNAzymes are catalytically active DNA molecules, which have previously been described in solution. Here, we organize these molecules into a series of two-dimensional (2D) arrays using a periodic arrangement of DNA structures based on the DNA double crossover motif. We demonstrate by means of atomic force microscopy that the DNAzymes are organized according to the design and that they retain their activity when attached in linear strings within the context of the 20 array.

Original languageEnglish (US)
Pages (from-to)1505-1507
Number of pages3
JournalNano Letters
Volume6
Issue number7
DOIs
StatePublished - Jul 2006

Fingerprint

Catalytic DNA
DNA
deoxyribonucleic acid
Molecules
molecules
Atomic force microscopy
crossovers
strings
atomic force microscopy

ASJC Scopus subject areas

  • Materials Science(all)
  • Electronic, Optical and Magnetic Materials
  • Chemistry (miscellaneous)

Cite this

Garibotti, A. V., Knudsen, S. M., Ellington, A. D., & Seeman, N. (2006). Functional DNAzymes organized into two-dimensional arrays. Nano Letters, 6(7), 1505-1507. https://doi.org/10.1021/nl0609955

Functional DNAzymes organized into two-dimensional arrays. / Garibotti, Alejandra V.; Knudsen, Scott M.; Ellington, Andrew D.; Seeman, Nadrian.

In: Nano Letters, Vol. 6, No. 7, 07.2006, p. 1505-1507.

Research output: Contribution to journalArticle

Garibotti, AV, Knudsen, SM, Ellington, AD & Seeman, N 2006, 'Functional DNAzymes organized into two-dimensional arrays', Nano Letters, vol. 6, no. 7, pp. 1505-1507. https://doi.org/10.1021/nl0609955
Garibotti, Alejandra V. ; Knudsen, Scott M. ; Ellington, Andrew D. ; Seeman, Nadrian. / Functional DNAzymes organized into two-dimensional arrays. In: Nano Letters. 2006 ; Vol. 6, No. 7. pp. 1505-1507.
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