Frontolimbic function and cortisol reactivity in response to emotional stimuli

James C. Root, Oliver Tuescher, Amy Cunningham-Bussel, Hong Pan, Jane Epstein, Margaret Altemus, Marylene Cloitre, Martin Goldstein, Michael Silverman, Daniella Furman, Joseph Ledoux, Bruce McEwen, Emily Stern, David Silbersweig

Research output: Contribution to journalArticle

Abstract

Frontolimbic structures involved in fear conditioning have also been associated with hypothalamic-pituitary-adrenal (HPA)-axis modulation, including amygdaloid, hippocampal, and ventromedial prefrontal cortex regions. Although HPA-axis function and endocrine changes have been investigated in the context of stress provocation, much research has not been conducted using functional neuroimaging in the study of the HPA axis and frontolimbic function in response to emotional stimuli. Using functional magnetic resonance imaging, the association of blood-oxygen-level dependent signal with salivary cortisol in response to an emotional visual scene paradigm was investigated, with prescan and postscan salivary cortisol analyzed as a covariate of interest during specific conditions. Cortisol reactivity to the paradigm was positively associated with amygdalar and hippocampal activity and negatively associated with ventromedial prefrontal cortex activity in conditions involving emotional imagery.

Original languageEnglish (US)
Pages (from-to)429-434
Number of pages6
JournalNeuroReport
Volume20
Issue number4
DOIs
StatePublished - Mar 4 2009

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Hydrocortisone
Prefrontal Cortex
Functional Neuroimaging
Imagery (Psychotherapy)
Fear
Magnetic Resonance Imaging
Oxygen
Research
Conditioning (Psychology)

Keywords

  • Amygdala
  • Cortisol
  • Hippocampus
  • Medial prefrontal cortex
  • Neuroimaging

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Root, J. C., Tuescher, O., Cunningham-Bussel, A., Pan, H., Epstein, J., Altemus, M., ... Silbersweig, D. (2009). Frontolimbic function and cortisol reactivity in response to emotional stimuli. NeuroReport, 20(4), 429-434. https://doi.org/10.1097/WNR.0b013e328326a031

Frontolimbic function and cortisol reactivity in response to emotional stimuli. / Root, James C.; Tuescher, Oliver; Cunningham-Bussel, Amy; Pan, Hong; Epstein, Jane; Altemus, Margaret; Cloitre, Marylene; Goldstein, Martin; Silverman, Michael; Furman, Daniella; Ledoux, Joseph; McEwen, Bruce; Stern, Emily; Silbersweig, David.

In: NeuroReport, Vol. 20, No. 4, 04.03.2009, p. 429-434.

Research output: Contribution to journalArticle

Root, JC, Tuescher, O, Cunningham-Bussel, A, Pan, H, Epstein, J, Altemus, M, Cloitre, M, Goldstein, M, Silverman, M, Furman, D, Ledoux, J, McEwen, B, Stern, E & Silbersweig, D 2009, 'Frontolimbic function and cortisol reactivity in response to emotional stimuli', NeuroReport, vol. 20, no. 4, pp. 429-434. https://doi.org/10.1097/WNR.0b013e328326a031
Root JC, Tuescher O, Cunningham-Bussel A, Pan H, Epstein J, Altemus M et al. Frontolimbic function and cortisol reactivity in response to emotional stimuli. NeuroReport. 2009 Mar 4;20(4):429-434. https://doi.org/10.1097/WNR.0b013e328326a031
Root, James C. ; Tuescher, Oliver ; Cunningham-Bussel, Amy ; Pan, Hong ; Epstein, Jane ; Altemus, Margaret ; Cloitre, Marylene ; Goldstein, Martin ; Silverman, Michael ; Furman, Daniella ; Ledoux, Joseph ; McEwen, Bruce ; Stern, Emily ; Silbersweig, David. / Frontolimbic function and cortisol reactivity in response to emotional stimuli. In: NeuroReport. 2009 ; Vol. 20, No. 4. pp. 429-434.
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