Frontal lobe activation during object alternation acquisition

David H. Zald, Clayton Curtis, Laura A. Chernitsky, José V. Pardo

Research output: Contribution to journalArticle

Abstract

Object alternation (OA) tasks are increasingly used as probes of ventral prefrontal functioning in humans. In the most common variant of the OA task, subjects must deduce the task rule through trial-and-error learning. To examine the neural correlates of OA acquisition, the authors measured regional cerebral blood flow with positron emission tomography while subjects acquired an OA task, performed a sensorimotor control condition, or performed already learned and practiced OA. As expected, activations emerged in the ventral prefrontal cortex. However, activation of the presupplemental motor area was more closely associated with successful task performance. The authors suggest that areas beyond the ventral prefrontal cortex are critically involved in OA acquisition.

Original languageEnglish (US)
Pages (from-to)97-105
Number of pages9
JournalNeuropsychology
Volume19
Issue number1
DOIs
StatePublished - Jan 2005

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Frontal Lobe
Prefrontal Cortex
Cerebrovascular Circulation
Regional Blood Flow
Motor Cortex
Task Performance and Analysis
Positron-Emission Tomography
Learning

ASJC Scopus subject areas

  • Biological Psychiatry
  • Neuropsychology and Physiological Psychology

Cite this

Frontal lobe activation during object alternation acquisition. / Zald, David H.; Curtis, Clayton; Chernitsky, Laura A.; Pardo, José V.

In: Neuropsychology, Vol. 19, No. 1, 01.2005, p. 97-105.

Research output: Contribution to journalArticle

Zald, David H. ; Curtis, Clayton ; Chernitsky, Laura A. ; Pardo, José V. / Frontal lobe activation during object alternation acquisition. In: Neuropsychology. 2005 ; Vol. 19, No. 1. pp. 97-105.
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