From attachment to independence

stress hormone control of ecologically relevant emergence of infants’ responses to threat

Adrienne Santiago, Chiye Aoki, Regina M. Sullivan

Research output: Contribution to journalReview article

Abstract

Young infant rat pups learn to approach cues associated with pain rather than learning amygdala-dependent fear. This approach response is considered caregiver-seeking and ecologically relevant within the context of attachment. With maturation, increases in the stress hormone corticosterone permit amygdala-dependent fear, which is crucial for survival during independent living. During the developmental transition from attachment to fear learning, maternal presence suppresses corticosterone elevation to block amygdala-dependent fear learning and re-engage the attachment circuitry. Early life trauma disrupts this developmental sequence by triggering a precocious increase of corticosterone, which permits amygdala-dependent threat responses. In this review, we explore the importance of the stress hormone corticosterone in infants’ transition from complete dependence on the caregiver to independence, with consideration for environmental influences on threat response ontogeny and mechanistic importance of social buffering of the stress response.

Original languageEnglish (US)
Pages (from-to)78-85
Number of pages8
JournalCurrent Opinion in Behavioral Sciences
Volume14
DOIs
StatePublished - Apr 1 2017

Fingerprint

Corticosterone
Amygdala
Fear
Hormones
Learning
Caregivers
Independent Living
Cues
Mothers
Pain
Survival
Wounds and Injuries

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

Cite this

From attachment to independence : stress hormone control of ecologically relevant emergence of infants’ responses to threat. / Santiago, Adrienne; Aoki, Chiye; Sullivan, Regina M.

In: Current Opinion in Behavioral Sciences, Vol. 14, 01.04.2017, p. 78-85.

Research output: Contribution to journalReview article

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