Free energy self-averaging in protein-sized random heteropolymers

J. Chuang, A. Y. Grosberg, M. Kardar

    Research output: Contribution to journalArticle

    Abstract

    Current theories of heteropolymers are inherently macroscopic, but are applied to mesoscopic proteins. To compute the free energy over sequences, one assumes self-averaging--a property established only in the macroscopic limit. By enumerating the states and energies of compact 18, 27, and 36mers on a lattice with an ensemble of random sequences, we test the self-averaging approximation. We find that fluctuations in the free energy between sequences are weak, and that self-averaging is valid at the scale of real proteins. The results validate sequence design methods which exponentially speed up computational design and simplify experimental realizations.

    Original languageEnglish (US)
    Article number078104
    Pages (from-to)78104
    Number of pages1
    JournalPhysical Review Letters
    Volume87
    Issue number7
    StatePublished - Aug 13 2001

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    free energy
    proteins
    approximation
    energy

    ASJC Scopus subject areas

    • Physics and Astronomy(all)

    Cite this

    Chuang, J., Grosberg, A. Y., & Kardar, M. (2001). Free energy self-averaging in protein-sized random heteropolymers. Physical Review Letters, 87(7), 78104. [078104].

    Free energy self-averaging in protein-sized random heteropolymers. / Chuang, J.; Grosberg, A. Y.; Kardar, M.

    In: Physical Review Letters, Vol. 87, No. 7, 078104, 13.08.2001, p. 78104.

    Research output: Contribution to journalArticle

    Chuang, J, Grosberg, AY & Kardar, M 2001, 'Free energy self-averaging in protein-sized random heteropolymers', Physical Review Letters, vol. 87, no. 7, 078104, pp. 78104.
    Chuang J, Grosberg AY, Kardar M. Free energy self-averaging in protein-sized random heteropolymers. Physical Review Letters. 2001 Aug 13;87(7):78104. 078104.
    Chuang, J. ; Grosberg, A. Y. ; Kardar, M. / Free energy self-averaging in protein-sized random heteropolymers. In: Physical Review Letters. 2001 ; Vol. 87, No. 7. pp. 78104.
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